iPTMnet Report for O43852 (CALU)


Protein Information

Cytoscape View


UniProt AC / UniProt ID O43852 / CALU_HUMAN
Protein Name Calumenin precursor
Gene Name Name: CALU
Organism Homo sapiens (Human)

PRO ID PR:O43852
DAG View
PRO Name calumenin (human)
Definition A calumenin that is encoded in the genome of human.
Short Label hCALU
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


O43852 (CALU) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S19 O-Glycosylation GlyGen 25813380
T22 O-Glycosylation GlyGen 25813380
S35 O-Glycosylation GlyGen 25813380
S35 Phosphorylation PhosphoSitePlus
K37 Ubiquitination PhosphoSitePlus
S44 Phosphorylation Q9H4B4 (PLK3) , Q9NYY3 (PLK2) IEDB   PhosphoSitePlus   UniProt 18691976, 35494241, 23186163, ...22828320, 20068231
Y47 Phosphorylation PhosphoSitePlus   UniProt 23186163
K59 Ubiquitination PhosphoSitePlus
T60 O-Glycosylation GlyGen   PhosphoSitePlus 25813380
T60 Phosphorylation Q9NYY3 (PLK2) , Q9H4B4 (PLK3) PhosphoSitePlus 22828320
T65 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 20068231, 18691976, 16964243, ...24275569
S69 Phosphorylation PhosphoSitePlus   UniProt 26091039
K70 Sumoylation PhosphoSitePlus
K70 Ubiquitination PhosphoSitePlus
K75 Ubiquitination PhosphoSitePlus
K79 Ubiquitination PhosphoSitePlus
K84 Ubiquitination PhosphoSitePlus
T89 Phosphorylation PhosphoSitePlus
K94 Ubiquitination PhosphoSitePlus
K98 Ubiquitination PhosphoSitePlus
Y106 Phosphorylation PhosphoSitePlus
R111 Methylation PhosphoSitePlus
K114 Ubiquitination PhosphoSitePlus
S125 Phosphorylation PhosphoSitePlus
Y129 Phosphorylation PhosphoSitePlus
N131 N-Glycosylation GlyGen   UniProt 23090970, 29741879, 19139490, ...19159218, 24190977
T133 O-Glycosylation GlyGen 33214551, 34725712, 35254053, ...34019948, 32119511, 35289036, 29249144
K165 Ubiquitination PhosphoSitePlus
K173 Ubiquitination PhosphoSitePlus
T177 Phosphorylation Q9H4B4 (PLK3) PhosphoSitePlus 22828320
Y185 Phosphorylation PhosphoSitePlus
Y187 Phosphorylation PhosphoSitePlus
T196 Phosphorylation Q9H4B4 (PLK3) , Q9NYY3 (PLK2) PhosphoSitePlus 22828320
T224 O-Glycosylation GlyGen 30459171
K248 Methylation PhosphoSitePlus
T254 Phosphorylation Q9H4B4 (PLK3) PhosphoSitePlus   UniProt 23186163, 22828320
K255 Ubiquitination PhosphoSitePlus
S261 O-Glycosylation GlyGen   PhosphoSitePlus 23584533
S261 Phosphorylation PhosphoSitePlus   UniProt 23186163
Y263 Phosphorylation PhosphoSitePlus
Y275 Phosphorylation PhosphoSitePlus
S277 Phosphorylation PhosphoSitePlus   UniProt 23186163
K281 Acetylation PhosphoSitePlus
K281 Ubiquitination PhosphoSitePlus
K287 Sumoylation PhosphoSitePlus
K287 Ubiquitination PhosphoSitePlus
K293 Ubiquitination PhosphoSitePlus
S300 Phosphorylation phospho.ELM   PhosphoSitePlus 22067460
Site PTM Type PTM Enzyme Score Source PMID
S44 Phosphorylation HPRD 18691976, 17081983, 20068231
T65 Phosphorylation HPRD 19413330, 18691976, 16964243, ...20068231
S69 Phosphorylation HPRD 18767875
Site PTM Type PTM Enzyme Score Source PMID
T73 Phosphorylation P68400 (CSNK2A1) PhosphoSitePlus 24136234
Site PTM Type PTM Enzyme Score Source PMID
T68 Phosphorylation PhosphoSitePlus
T73 Phosphorylation PhosphoSitePlus
S77 Phosphorylation PhosphoSitePlus
K92 Ubiquitination PhosphoSitePlus
K102 Ubiquitination PhosphoSitePlus
K106 Ubiquitination PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K37 T37 Biomuta DOID:5158 / pleural cancer [ cosmic ]
T65 I65 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
T73 I73 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
R111 L111 Biomuta DOID:3571 / liver cancer [ cosmic ] DOID:1324 / lung cancer [ cosmic, icgc ]
R111 Q111 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
K114 * Biomuta DOID:3571 / liver cancer [ cosmic ]
Y129 H129 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
T133 P133 Biomuta DOID:1612 / breast cancer [ cosmic ]
Y187 * Biomuta DOID:1324 / lung cancer [ cosmic ]
T224 I224 Biomuta DOID:10283 / prostate cancer [ cosmic, icgc ]