iPTMnet Report for O43847 (NRDC)


Protein Information

Cytoscape View


UniProt AC / UniProt ID O43847 / NRDC_HUMAN
Protein Name Nardilysin precursor
Gene Name Name: NRDC
Synonyms:NRD1;
Organism Homo sapiens (Human)

PRO ID PR:O43847
DAG View
PRO Name nardilysin (human)
Definition A nardilysin that is encoded in the genome of human.
Short Label hNRDC
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


O43847 (NRDC) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
C11 Methylation IEDB 31844290
S58 Phosphorylation PhosphoSitePlus
T59 Phosphorylation PhosphoSitePlus
S61 Phosphorylation PhosphoSitePlus
S76 Phosphorylation IEDB 27920218
S86 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163
S94 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 21406692, 23186163, 18669648, ...19690332, 20068231
S96 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163
S106 Phosphorylation PhosphoSitePlus
S108 Phosphorylation PhosphoSitePlus
K111 Ubiquitination PhosphoSitePlus
K257 Ubiquitination PhosphoSitePlus
K258 Acetylation PhosphoSitePlus
C269 Methylation IEDB 31844290
K284 Ubiquitination PhosphoSitePlus
Y315 Phosphorylation PhosphoSitePlus
K326 Ubiquitination PhosphoSitePlus
K342 Ubiquitination PhosphoSitePlus
K352 Ubiquitination PhosphoSitePlus
T391 Phosphorylation PhosphoSitePlus
K619 Ubiquitination PhosphoSitePlus
K670 Ubiquitination PhosphoSitePlus
C674 Methylation IEDB 31844290
K682 Ubiquitination PhosphoSitePlus
K913 Ubiquitination PhosphoSitePlus
Y924 Phosphorylation PhosphoSitePlus
S926 Phosphorylation PhosphoSitePlus
T928 Phosphorylation PhosphoSitePlus
K955 Ubiquitination PhosphoSitePlus
S970 Phosphorylation PhosphoSitePlus
K993 Acetylation PhosphoSitePlus
K994 Ubiquitination PhosphoSitePlus
S1000 Phosphorylation PhosphoSitePlus
S1001 Phosphorylation PhosphoSitePlus
K1025 Ubiquitination PhosphoSitePlus
K1061 Ubiquitination PhosphoSitePlus
K1065 Ubiquitination PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S86 Phosphorylation HPRD 18669648, 19415658, 20068231
S94 Phosphorylation HPRD 17322306, 20058876, 18212344, ...18767875, 19664994, 19664995, 19651622, 18669648, 18707149, 20166139, 20068231
S96 Phosphorylation HPRD 19651622, 18669648
T206 Phosphorylation PhosphoSitePlus
T207 Phosphorylation PhosphoSitePlus
K209 Ubiquitination PhosphoSitePlus
S214 Phosphorylation PhosphoSitePlus
S220 Phosphorylation PhosphoSitePlus
K229 Ubiquitination PhosphoSitePlus
K234 Ubiquitination PhosphoSitePlus
Y247 Phosphorylation PhosphoSitePlus
T459 Phosphorylation HPRD 20068231


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
T59 A59 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
T59 I59 Biomuta DOID:10534 / stomach cancer [ cosmic ]
S96 N96 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
K111 E111 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
T207 A207 Biomuta DOID:1612 / breast cancer [ cosmic ]
S214 N214 Biomuta DOID:9256 / colorectal cancer [ cosmic ] DOID:10534 / stomach cancer [ cosmic ]
K229 N229 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ] DOID:1324 / lung cancer [ cosmic, icgc ]
Y315 C315 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
K342 T342 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
K342 N342 Biomuta DOID:1793 / pancreatic cancer [ cosmic ] DOID:9256 / colorectal cancer [ cosmic ]
K670 T670 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
K993 N993 Biomuta DOID:1319 / brain cancer [ icgc ]
K1061 T1061 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]