Protein Information

Cytoscape View


UniProt AC / UniProt ID O43823 / AKAP8_HUMAN
Protein Name A-kinase anchor protein 8
Gene Name Name: AKAP8
Synonyms:AKAP95;
Organism Homo sapiens (Human)

PRO ID PR:O43823
DAG View
PRO Name A-kinase anchor protein 8 (human)
Definition An A-kinase anchor protein 8 that is encoded in the genome of human.
Short Label hAKAP8
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


O43823 (AKAP8) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
Y51 Phosphorylation P12931 (SRC) , P07948 (LYN) PhosphoSitePlus 25770215
Y53 Phosphorylation P12931 (SRC) , P07948 (LYN) PhosphoSitePlus 25770215
Y80 Phosphorylation P12931 (SRC) , P07948 (LYN) PhosphoSitePlus 25770215
K95 Ubiquitination PhosphoSitePlus
R109 Methylation PhosphoSitePlus
S112 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 21406692, 16964243
S136 Phosphorylation PhosphoSitePlus
Y146 Phosphorylation P07948 (LYN) , P12931 (SRC) PhosphoSitePlus 25770215
S149 Phosphorylation PhosphoSitePlus
Y150 Phosphorylation P07948 (LYN) , P12931 (SRC) PhosphoSitePlus 25770215
Y152 Phosphorylation P12931 (SRC) , P07948 (LYN) PhosphoSitePlus 25770215, 18698806
Y154 Phosphorylation P12931 (SRC) , P07948 (LYN) PhosphoSitePlus 25770215
S165 Phosphorylation PhosphoSitePlus
Y170 Phosphorylation P12931 (SRC) , P07948 (LYN) PhosphoSitePlus 25770215
S182 Phosphorylation PhosphoSitePlus
R188 Methylation PhosphoSitePlus
R190 Methylation PhosphoSitePlus
R194 Methylation PhosphoSitePlus
R198 Methylation PhosphoSitePlus
S199 Phosphorylation PhosphoSitePlus   UniProt 23186163
Y229 Phosphorylation PhosphoSitePlus
R233 Methylation PhosphoSitePlus
R242 Methylation PhosphoSitePlus
R277 Methylation PhosphoSitePlus   UniProt 24129315
R281 Methylation PhosphoSitePlus
T301 Phosphorylation PhosphoSitePlus
K306 Ubiquitination PhosphoSitePlus
Y311 Phosphorylation P07948 (LYN) , P12931 (SRC) PhosphoSitePlus 25770215
K317 Ubiquitination PhosphoSitePlus
S323 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 19413330, 21406692, 23186163, ...17081983, 19664995, 18452278, 19651622, 18669648, 19690332, 24275569, 19415658, 20068231
S328 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 19413330, 21406692, 23186163, ...17081983, 18691976, 18767875, 15302935, 19664995, 18452278, 17322306, 19664994, 18669648, 19690332, 24275569, 19651622, 19415658, 20068231, 19691289
S339 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 18669648, 21406692, 17081983, ...20068231
C351 S-Nitrosylation dbSNO 26338901
S353 Phosphorylation PhosphoSitePlus
S399 Phosphorylation PhosphoSitePlus
K407 Ubiquitination PhosphoSitePlus
T423 Phosphorylation PhosphoSitePlus
K424 Ubiquitination PhosphoSitePlus
Y436 Phosphorylation P07948 (LYN) , P12931 (SRC) PhosphoSitePlus 25770215
K465 Ubiquitination PhosphoSitePlus
K517 Ubiquitination PhosphoSitePlus
K524 Ubiquitination PhosphoSitePlus
K534 Acetylation PhosphoSitePlus
K538 Acetylation PhosphoSitePlus
Y539 Phosphorylation P12931 (SRC) , P07948 (LYN) PhosphoSitePlus 25770215
S644 Phosphorylation PhosphoSitePlus
T681 Phosphorylation PhosphoSitePlus
S685 Phosphorylation PhosphoSitePlus   UniProt 23186163


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
Y152 C152 Biomuta DOID:363 / uterine cancer [ tcga ]
S182 F182 Biomuta DOID:1909 / melanoma [ icgc, tcga ]
R188 Q188 Biomuta DOID:0060119 / pharynx cancer [ cosmic ]
R198 Q198 Biomuta DOID:363 / uterine cancer [ tcga ]
Y229 * Biomuta DOID:3571 / liver cancer [ icgc ]
R242 Q242 Biomuta DOID:1909 / melanoma [ cosmic ]
R277 H277 Biomuta DOID:1793 / pancreatic cancer [ icgc ] DOID:363 / uterine cancer [ tcga ] DOID:0070003 / blastoma [ cosmic ]
R281 W281 Biomuta DOID:5041 / esophageal cancer [ tcga ]
S339 A339 Biomuta DOID:9256 / colorectal cancer [ tcga ]
S339 * Biomuta DOID:3953 / adrenal gland cancer [ tcga ]
T423 S423 Biomuta DOID:1612 / breast cancer [ cosmic, icgc, tcga ]
K534 Q534 Biomuta DOID:1612 / breast cancer [ cosmic, icgc, tcga ]
K534 R534 Biomuta DOID:1909 / melanoma [ icgc, tcga ]
T681 A681 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc, tcga ]