iPTMnet Report for O43809 (NUDT21)


Protein Information

Cytoscape View


UniProt AC / UniProt ID O43809 / CPSF5_HUMAN
Protein Name Cleavage and polyadenylation specificity factor subunit 5
Gene Name Name: NUDT21
Synonyms:CFIM25;
Organism Homo sapiens (Human)

PRO ID PR:O43809
DAG View
PRO Name cleavage and polyadenylation specificity factor subunit 5 (human)
Definition A cleavage and polyadenylation specificity factor subunit 5 that is encoded in the genome of human.
Short Label hNUDT21
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


O43809 (NUDT21) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
R8 Methylation PhosphoSitePlus
S9 Phosphorylation PhosphoSitePlus
R15 Methylation PhosphoSitePlus   UniProt 24129315
K23 Acetylation PhosphoSitePlus   UniProt 19608861, 17172643
K23 Methylation PhosphoSitePlus
K23 Ubiquitination PhosphoSitePlus
Y24 Phosphorylation PhosphoSitePlus
K29 Acetylation PhosphoSitePlus   UniProt 19608861
K29 Ubiquitination PhosphoSitePlus
T36 Phosphorylation PhosphoSitePlus
Y40 Phosphorylation HPRD   PhosphoSitePlus   UniProt 15592455
Y45 Phosphorylation PhosphoSitePlus
T49 Phosphorylation PhosphoSitePlus
K50 Ubiquitination PhosphoSitePlus
K56 Acetylation PhosphoSitePlus   UniProt 19608861
K56 Ubiquitination PhosphoSitePlus
K73 Acetylation PhosphoSitePlus
K73 Ubiquitination PhosphoSitePlus
T101 Phosphorylation HPRD   PhosphoSitePlus 20068231
T102 Phosphorylation HPRD   PhosphoSitePlus 20068231
K122 Acetylation PhosphoSitePlus
K122 Ubiquitination PhosphoSitePlus
K173 Acetylation PhosphoSitePlus
K182 Ubiquitination PhosphoSitePlus
K189 Acetylation PhosphoSitePlus
K189 Ubiquitination PhosphoSitePlus
K192 Ubiquitination PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
R8 C8 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S9 L9 Biomuta DOID:4159 / skin cancer [ cosmic ] DOID:5041 / esophageal cancer [ cosmic ]
R15 W15 Biomuta DOID:4159 / skin cancer [ cosmic ]
K50 E50 Biomuta DOID:3571 / liver cancer [ cosmic ]