Protein Information

Cytoscape View


UniProt AC / UniProt ID O43781 / DYRK3_HUMAN
Protein Name Dual specificity tyrosine-phosphorylation-regulated kinase 3
Gene Name Name: DYRK3
Organism Homo sapiens (Human)

PRO ID PR:O43781
DAG View
PRO Name dual specificity tyrosine-phosphorylation-regulated kinase 3 (human)
Definition A dual specificity tyrosine-phosphorylation-regulated kinase 3 that is encoded in the genome of human.
Short Label hDYRK3
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


O43781 (DYRK3) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K128 Ubiquitination PhosphoSitePlus
K148 Ubiquitination PhosphoSitePlus
K151 Ubiquitination PhosphoSitePlus
Y209 Phosphorylation phospho.ELM   PhosphoSitePlus 15592455
K217 Ubiquitination PhosphoSitePlus
K330 Ubiquitination PhosphoSitePlus
S350 Phosphorylation PhosphoSitePlus   UniProt 29634919
T351 Phosphorylation PhosphoSitePlus
Y367 Phosphorylation PhosphoSitePlus
T368 Phosphorylation PhosphoSitePlus
Y369 Phosphorylation phospho.ELM   PhosphoSitePlus 18083107
S372 Phosphorylation PhosphoSitePlus
K446 Ubiquitination PhosphoSitePlus
Y451 Phosphorylation PhosphoSitePlus
S453 Phosphorylation PhosphoSitePlus
T455 Phosphorylation PhosphoSitePlus
T456 Phosphorylation PhosphoSitePlus
S469 Phosphorylation PhosphoSitePlus
S480 Phosphorylation PhosphoSitePlus
K481 Acetylation PhosphoSitePlus
T485 Phosphorylation PhosphoSitePlus
K488 Acetylation PhosphoSitePlus
Y493 Phosphorylation PhosphoSitePlus
K524 Ubiquitination PhosphoSitePlus
T532 Phosphorylation PhosphoSitePlus
S537 Phosphorylation PhosphoSitePlus
K554 Ubiquitination PhosphoSitePlus
K564 Ubiquitination PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
Y209 Phosphorylation HPRD 15592455
Y369 Phosphorylation HPRD 18083107
Site PTM Type PTM Enzyme Score Source PMID
Y189 Phosphorylation HPRD 15592455
Y349 Phosphorylation HPRD 18083107


O43781 (DYRK3) as PTM Enzyme



Substrate Site Score Source PMID
P16220 (CREB1) S133 phospho.ELM 12356771
Q96B36 (AKT1S1) T246 neXtProt   PhosphoSitePlus 23415227


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S372 C372 Biomuta DOID:1324 / lung cancer [ tcga ]
T532 A532 Biomuta DOID:9256 / colorectal cancer [ tcga ]
K554 E554 Biomuta DOID:3571 / liver cancer [ tcga ]