iPTMnet Report for O43781 (DYRK3)
Protein Information
| UniProt AC / UniProt ID | O43781 / DYRK3_HUMAN |
| Protein Name | Dual specificity tyrosine-phosphorylation-regulated kinase 3 |
| Gene Name | Name: DYRK3 |
| Organism | Homo sapiens (Human) |
| PRO ID | PR:O43781 |
| PRO Name | dual specificity tyrosine-phosphorylation-regulated kinase 3 (human) |
| Definition | A dual specificity tyrosine-phosphorylation-regulated kinase 3 that is encoded in the genome of human. |
| Short Label | hDYRK3 |
| Category | organism-gene |
DAG ViewO43781 (DYRK3) as Substrate
 |
Site | PTM Type | PTM Enzyme | Score | Source | PMID |
|---|---|---|---|---|---|---|
| K128 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K148 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K151 | Ubiquitination | score1 | PhosphoSitePlus | |||
| Y209 | Phosphorylation | score2 | phospho.ELM PhosphoSitePlus | 15592455 | ||
| K217 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K330 | Ubiquitination | score1 | PhosphoSitePlus | |||
| S350 | Phosphorylation | score3 | PhosphoSitePlus UniProt | 29634919 | ||
| T351 | Phosphorylation | score1 | PhosphoSitePlus | |||
| Y367 | Phosphorylation | score1 | PhosphoSitePlus | |||
| T368 | Phosphorylation | score1 | PhosphoSitePlus | |||
| Y369 | Phosphorylation | score2 | phospho.ELM PhosphoSitePlus | 18083107 | ||
| S372 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K446 | Ubiquitination | score1 | PhosphoSitePlus | |||
| Y451 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S453 | Phosphorylation | score1 | PhosphoSitePlus | |||
| T455 | Phosphorylation | score1 | PhosphoSitePlus | |||
| T456 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S469 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S480 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K481 | Acetylation | score1 | PhosphoSitePlus | |||
| T485 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K488 | Acetylation | score1 | PhosphoSitePlus | |||
| Y493 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K524 | Ubiquitination | score1 | PhosphoSitePlus | |||
| T532 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S537 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K554 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K564 | Ubiquitination | score1 | PhosphoSitePlus |
O43781 (DYRK3) as PTM Enzyme
|
Substrate | Site | Score | Source | PMID |
|---|---|---|---|---|---|
| Q96B36 (AKT1S1) | T246 | score3 | neXtProt PhosphoSitePlus | 23415227 |
PTM sites affected in variants
| Site | Variant | Source | PMID | Disease [Sample source] |
|---|---|---|---|---|
| K148 | R148 | Biomuta | DOID:9256 / colorectal cancer [ cosmic ] | |
| K217 | N217 | Biomuta | DOID:9256 / colorectal cancer [ cosmic ] | |
| S372 | C372 | Biomuta | DOID:1324 / lung cancer [ cosmic, icgc ] | |
| Y493 | C493 | Biomuta | DOID:5041 / esophageal cancer [ cosmic ] | |
| T532 | A532 | Biomuta | DOID:9256 / colorectal cancer [ cosmic, icgc ] | |
| S537 | * | Biomuta | DOID:4159 / skin cancer [ cosmic ] | |
| K554 | E554 | Biomuta | DOID:3571 / liver cancer [ cosmic, icgc ] |
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