iPTMnet Report for O43768 (ENSA)


Protein Information

Cytoscape View


UniProt AC / UniProt ID O43768 / ENSA_HUMAN
Protein Name Alpha-endosulfine
Gene Name Name: ENSA
Organism Homo sapiens (Human)

PRO ID PR:O43768
DAG View
PRO Name alpha-endosulfine (human)
Definition An alpha-endosulfine that is encoded in the genome of human.
Short Label hENSA
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


O43768 (ENSA) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S2 Acetylation UniProt 21406692, 20068231
S2 Phosphorylation PhosphoSitePlus   UniProt 21406692, 23186163, 17081983, ...20068231
K4 Acetylation PhosphoSitePlus
T14 Phosphorylation PhosphoSitePlus
T21 Phosphorylation PhosphoSitePlus   UniProt 23186163
Y41 Phosphorylation PhosphoSitePlus
S43 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 23186163, 17287340
K47 Acetylation PhosphoSitePlus
K47 Ubiquitination PhosphoSitePlus
S51 Phosphorylation PhosphoSitePlus
K56 Methylation PhosphoSitePlus
K56 Ubiquitination PhosphoSitePlus
K60 Methylation PhosphoSitePlus
K63 Acetylation PhosphoSitePlus
K63 Ubiquitination PhosphoSitePlus
Y64 Phosphorylation PhosphoSitePlus
S67 Phosphorylation phospho.ELM   PRO   PhosphoSitePlus   RLIMS-P 32085646, 18088087, 27889260, ...26653855, 27551054, 18669648
Y70 Phosphorylation phospho.ELM   PhosphoSitePlus 17287340
K74 Ubiquitination PhosphoSitePlus
K76 Ubiquitination PhosphoSitePlus
K80 Ubiquitination PhosphoSitePlus
S84 Phosphorylation PhosphoSitePlus
K89 Acetylation PhosphoSitePlus
K89 Ubiquitination PhosphoSitePlus
T93 O-Glycosylation GlyGen   PhosphoSitePlus 29485866, 30379171, 31373491, ...23584533
T99 O-Glycosylation GlyGen   PhosphoSitePlus 23584533
T99 Phosphorylation PhosphoSitePlus
K107 Ubiquitination PhosphoSitePlus
S108 Phosphorylation PhosphoSitePlus
S109 Phosphorylation PhosphoSitePlus   RLIMS-P   UniProt 32085646, 21406692, 18973346, ...20068231
T112 Phosphorylation PhosphoSitePlus
S113 Phosphorylation PhosphoSitePlus
K114 Acetylation PhosphoSitePlus
K114 Ubiquitination PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S2 Phosphorylation HPRD 19651622, 17081983, 20068231
S43 Phosphorylation HPRD 17287340
S67 Phosphorylation HPRD 18088087, 20068231
Y70 Phosphorylation HPRD 17016520, 17287340
S108 Phosphorylation HPRD 17924679
S109 Phosphorylation HPRD 19651622, 20166139, 20068231, ...17924679
T112 Phosphorylation HPRD 17924679
S113 Phosphorylation HPRD 19651622, 17924679
Site PTM Type PTM Enzyme Score Source PMID
S2 Phosphorylation HPRD 19651622, 17081983, 20068231
S43 Phosphorylation HPRD 17287340
S67 Phosphorylation HPRD 18088087, 20068231
Y70 Phosphorylation HPRD 17016520, 17287340
S108 Phosphorylation HPRD 17924679
S109 Phosphorylation HPRD 19651622, 20166139, 20068231, ...17924679
T112 Phosphorylation HPRD 17924679
S113 Phosphorylation HPRD 19651622, 17924679
Site PTM Type PTM Enzyme Score Source PMID
S2 Phosphorylation HPRD 19651622, 17081983, 20068231
S43 Phosphorylation HPRD 17287340
Y63 Phosphorylation PhosphoSitePlus
Y80 Phosphorylation PhosphoSitePlus
S83 Phosphorylation HPRD   PhosphoSitePlus 18088087, 20068231
Y86 Phosphorylation HPRD   PhosphoSitePlus 17016520, 17287340
S124 Phosphorylation HPRD 17924679
S125 Phosphorylation HPRD 19651622, 20166139, 20068231, ...17924679
T128 Phosphorylation HPRD 17924679
S129 Phosphorylation HPRD 19651622, 17924679
Site PTM Type PTM Enzyme Score Source PMID
S39 Phosphorylation HPRD 17287340
S63 Phosphorylation HPRD 18088087, 20068231
Y66 Phosphorylation HPRD 17016520, 17287340
S104 Phosphorylation HPRD 17924679
S105 Phosphorylation HPRD 19651622, 20166139, 20068231, ...17924679
T108 Phosphorylation HPRD 17924679
S109 Phosphorylation HPRD 19651622, 17924679
Site PTM Type PTM Enzyme Score Source PMID
S39 Phosphorylation HPRD 17287340
S63 Phosphorylation HPRD 18088087, 20068231
Y66 Phosphorylation HPRD 17016520, 17287340
S104 Phosphorylation HPRD 17924679
S105 Phosphorylation HPRD 19651622, 20166139, 20068231, ...17924679
T108 Phosphorylation HPRD 17924679
S109 Phosphorylation HPRD 19651622, 17924679
Site PTM Type PTM Enzyme Score Source PMID
S39 Phosphorylation HPRD 17287340
S79 Phosphorylation HPRD 18088087, 20068231
Y82 Phosphorylation HPRD 17016520, 17287340
S120 Phosphorylation HPRD 17924679
S121 Phosphorylation HPRD 19651622, 20166139, 20068231, ...17924679
T124 Phosphorylation HPRD 17924679
S125 Phosphorylation HPRD 19651622, 17924679
Site PTM Type PTM Enzyme Score Source PMID
S2 Phosphorylation HPRD 19651622, 17081983, 20068231
S43 Phosphorylation HPRD 17287340
Site PTM Type PTM Enzyme Score Source PMID
S2 Phosphorylation HPRD 19651622, 17081983, 20068231
S43 Phosphorylation HPRD 17287340
S83 Phosphorylation HPRD 18088087, 20068231
Y86 Phosphorylation HPRD 17016520, 17287340
S124 Phosphorylation HPRD 17924679
S125 Phosphorylation HPRD 19651622, 20166139, 20068231, ...17924679
T128 Phosphorylation HPRD 17924679
S129 Phosphorylation HPRD 19651622, 17924679


Proteoforms

PRO ID (Short Label) Sites PTM Enzyme Source PMID
PR:000047284 (hENSA/InitMet-/Phos:2) pS67 PRO


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation O43768 (ENSA) S109 P37840 (SNCA) inhibited_association eFIP 18973346


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S2 Y2 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
K4 T4 Biomuta DOID:263 / kidney cancer [ cosmic, icgc ]
Y41 F41 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
S51 A51 Biomuta DOID:1612 / breast cancer [ cosmic, icgc, cosmic, icgc, cosmic, icgc, cosmic, icgc ] DOID:1324 / lung cancer [ cosmic, icgc ]
K114 R114 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]