iPTMnet Report for O43752 (STX6)


Protein Information

Cytoscape View


UniProt AC / UniProt ID O43752 / STX6_HUMAN
Protein Name Syntaxin-6
Gene Name Name: STX6
Organism Homo sapiens (Human)

PRO ID PR:O43752
DAG View
PRO Name syntaxin-6 (human)
Definition A syntaxin-6 that is encoded in the genome of human.
Short Label hSTX6
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


O43752 (STX6) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S2 Acetylation UniProt 20068231
S2 Phosphorylation PhosphoSitePlus   UniProt 23186163, 20068231
K77 Ubiquitination PhosphoSitePlus
T83 Phosphorylation PhosphoSitePlus
S86 Phosphorylation PhosphoSitePlus
K89 Ubiquitination PhosphoSitePlus
S107 Phosphorylation PhosphoSitePlus
K118 Ubiquitination PhosphoSitePlus
S127 Phosphorylation PhosphoSitePlus
S129 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 17525332, 23186163
T134 Phosphorylation PhosphoSitePlus
T137 Phosphorylation PhosphoSitePlus
K139 Ubiquitination PhosphoSitePlus
Y140 Phosphorylation PhosphoSitePlus
S152 Phosphorylation PhosphoSitePlus   UniProt 19690332
K184 Ubiquitination PhosphoSitePlus
T229 Phosphorylation PhosphoSitePlus
S230 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S2 Phosphorylation HPRD 18578522, 20068231
S127 Phosphorylation HPRD 20068231
S129 Phosphorylation HPRD 17525332, 20068231


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S86 I86 Biomuta [ cosmic ]
S107 P107 Biomuta DOID:1319 / brain cancer [ cosmic ]
S127 N127 Biomuta DOID:363 / uterine cancer [ icgc ]
K139 E139 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S152 Y152 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S230 C230 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]