iPTMnet Report for O43741 (PRKAB2)


Protein Information

Cytoscape View


UniProt AC / UniProt ID O43741 / AAKB2_HUMAN
Protein Name 5'-AMP-activated protein kinase subunit beta-2
Gene Name Name: PRKAB2
Organism Homo sapiens (Human)

PRO ID PR:O43741
DAG View
PRO Name 5'-AMP-activated protein kinase subunit beta-2 (human)
Definition A 5'-AMP-activated protein kinase subunit beta-2 that is encoded in the genome of human.
Short Label hPRKAB2
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


O43741 (PRKAB2) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S21 Phosphorylation PhosphoSitePlus
S39 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
T40 Phosphorylation PhosphoSitePlus
S47 Phosphorylation PhosphoSitePlus
K57 Ubiquitination PhosphoSitePlus
S61 Phosphorylation PhosphoSitePlus
S69 Phosphorylation PhosphoSitePlus
K71 Ubiquitination PhosphoSitePlus
S93 Phosphorylation PhosphoSitePlus
S95 Phosphorylation PhosphoSitePlus   UniProt 24275569
S100 Phosphorylation PhosphoSitePlus
S108 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 19369195, 21406692, 23186163, ...18691976, 18318008, 18669648, 24275569, 19690332
T148 Phosphorylation PhosphoSitePlus   RLIMS-P   UniProt 26831516, 24275569
K157 Ubiquitination PhosphoSitePlus
S158 Phosphorylation PhosphoSitePlus   UniProt 24275569
S170 Phosphorylation PhosphoSitePlus   UniProt 24275569
S173 Phosphorylation PhosphoSitePlus
S182 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S183 Phosphorylation PhosphoSitePlus
S184 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 20068231
Y189 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
Y194 Phosphorylation PhosphoSitePlus
S204 Phosphorylation PhosphoSitePlus
Y263 Phosphorylation PhosphoSitePlus
K270 Ubiquitination PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S39 Phosphorylation HPRD 19413330, 18691976, 18669648, ...20068231
T40 Phosphorylation HPRD 19413330, 20068231
S108 Phosphorylation HPRD 20166139, 18691976, 18669648, ...18452278, 20230923
T148 Phosphorylation HPRD 20166139
S158 Phosphorylation HPRD 20166139
S173 Phosphorylation HPRD 20166139
S182 Phosphorylation HPRD 18669648, 20068231
S183 Phosphorylation HPRD 19415658
S184 Phosphorylation HPRD 19413330, 18691976, 19651622, ...18669648, 19415658, 20068231
Y189 Phosphorylation HPRD 18669648


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S21 A21 Biomuta DOID:1793 / pancreatic cancer [ cosmic ]
K57 N57 Biomuta DOID:363 / uterine cancer [ icgc ]
S69 F69 Biomuta DOID:4159 / skin cancer [ cosmic ]
S93 Y93 Biomuta DOID:10534 / stomach cancer [ cosmic ]
S158 F158 Biomuta DOID:4159 / skin cancer [ cosmic ] DOID:1612 / breast cancer [ cosmic ]
S182 P182 Biomuta DOID:1324 / lung cancer [ cosmic ]
S182 F182 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ] DOID:1324 / lung cancer [ cosmic ]
K270 M270 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]