iPTMnet Report for O43709 (BUD23)


Protein Information

Cytoscape View


UniProt AC / UniProt ID O43709 / BUD23_HUMAN
Protein Name Probable 18S rRNA (guanine-N(7))-methyltransferase
Gene Name Name: BUD23
Synonyms:MERM1,WBSCR22;ORFNames:HUSSY-03,PP3381;
Organism Homo sapiens (Human)

PRO ID PR:O43709
DAG View
PRO Name probable 18S rRNA (guanine-N(7))-methyltransferase (human)
Definition A probable 18S rRNA (guanine-N(7))-methyltransferase that is encoded in the genome of human.
Short Label hBUD23
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


O43709 (BUD23) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
C55 Methylation IEDB 31844290
C62 Methylation IEDB 31844290
K134 Ubiquitination PhosphoSitePlus
S135 Phosphorylation PhosphoSitePlus
K180 Ubiquitination PhosphoSitePlus
K196 Ubiquitination PhosphoSitePlus
K198 Methylation PhosphoSitePlus
K198 Ubiquitination PhosphoSitePlus
S240 Phosphorylation PhosphoSitePlus   UniProt 23186163
S248 Phosphorylation PhosphoSitePlus
K255 Ubiquitination PhosphoSitePlus
K256 Ubiquitination PhosphoSitePlus
Y272 Phosphorylation PhosphoSitePlus
T273 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K134 * Biomuta DOID:1324 / lung cancer [ cosmic ]
S240 L240 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S240 P240 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ] DOID:2531 / hematologic cancer [ cosmic ]
S248 R248 Biomuta DOID:8618 / oral cavity cancer [ cosmic ]
K256 N256 Biomuta DOID:363 / uterine cancer [ icgc ]