Protein Information

Cytoscape View


UniProt AC / UniProt ID O43707 / ACTN4_HUMAN
Protein Name Alpha-actinin-4
Gene Name Name: ACTN4
Organism Homo sapiens (Human)

PRO ID PR:O43707
DAG View
PRO Name alpha-actinin-4 (human)
Definition An alpha-actinin-4 that is encoded in the genome of human.
Short Label hACTN4
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


O43707 (ACTN4) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
Y4 Phosphorylation Q05397 (PTK2) PhosphoSitePlus   RLIMS-P   Signor 26012634, 29274473, 23454549, ...19920151
Y11 Phosphorylation PhosphoSitePlus   RLIMS-P 29274473
Y13 Phosphorylation PhosphoSitePlus   RLIMS-P 29274473
Y31 Phosphorylation Q05397 (PTK2) PhosphoSitePlus   RLIMS-P   Signor 26012634, 23454549, 29274473, ...19920151
K50 Ubiquitination PhosphoSitePlus
K54 Ubiquitination PhosphoSitePlus
K66 Ubiquitination PhosphoSitePlus
T69 Phosphorylation PhosphoSitePlus
K83 Acetylation PhosphoSitePlus
S92 Phosphorylation PhosphoSitePlus
K108 Acetylation PhosphoSitePlus
K108 Ubiquitination PhosphoSitePlus
K114 Acetylation PhosphoSitePlus   UniProt 19608861
S121 Phosphorylation PhosphoSitePlus
K122 Ubiquitination PhosphoSitePlus
K125 Ubiquitination PhosphoSitePlus
T142 Phosphorylation PhosphoSitePlus
S159 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648, 17081983
T163 Phosphorylation PhosphoSitePlus
S164 Phosphorylation PhosphoSitePlus
K181 Ubiquitination PhosphoSitePlus
S191 Phosphorylation PhosphoSitePlus
Y212 Phosphorylation PhosphoSitePlus
K214 Acetylation PhosphoSitePlus
K214 Ubiquitination PhosphoSitePlus
K217 Acetylation PhosphoSitePlus
K217 Ubiquitination PhosphoSitePlus
K233 Acetylation PhosphoSitePlus
K233 Ubiquitination PhosphoSitePlus
Y234 Phosphorylation PhosphoSitePlus
K239 Ubiquitination PhosphoSitePlus
T249 Phosphorylation PhosphoSitePlus   UniProt 24275569
Y260 Phosphorylation PhosphoSitePlus
S262 Phosphorylation PhosphoSitePlus
S263 Phosphorylation PhosphoSitePlus
Y265 Phosphorylation Q05397 (PTK2) phospho.ELM   PhosphoSitePlus   Signor 18083107, 23454549
S269 Phosphorylation PhosphoSitePlus
R280 Methylation PhosphoSitePlus
K283 Acetylation PhosphoSitePlus
Y298 Phosphorylation PhosphoSitePlus
S303 Phosphorylation PhosphoSitePlus
R310 Methylation PhosphoSitePlus
T312 Phosphorylation PhosphoSitePlus
R319 Methylation PhosphoSitePlus
K323 Ubiquitination PhosphoSitePlus
T324 Phosphorylation PhosphoSitePlus
K331 Acetylation PhosphoSitePlus
K331 Ubiquitination PhosphoSitePlus
Y338 Phosphorylation PhosphoSitePlus
K346 Ubiquitination PhosphoSitePlus
K350 Ubiquitination PhosphoSitePlus
C351 S-Nitrosylation dbSNO 26338901, 22178444
T359 Phosphorylation PhosphoSitePlus
T362 Phosphorylation PhosphoSitePlus
S367 Phosphorylation PhosphoSitePlus
K378 Ubiquitination PhosphoSitePlus
S381 Phosphorylation PhosphoSitePlus
Y397 Phosphorylation PhosphoSitePlus   RLIMS-P 29274473
K417 Acetylation PhosphoSitePlus
K417 Ubiquitination PhosphoSitePlus
K421 Ubiquitination PhosphoSitePlus
S423 Phosphorylation PhosphoSitePlus
T429 Phosphorylation PhosphoSitePlus
K432 Acetylation PhosphoSitePlus
K432 Ubiquitination PhosphoSitePlus
K437 Acetylation PhosphoSitePlus
Y441 Phosphorylation PhosphoSitePlus
T445 Phosphorylation PhosphoSitePlus
S447 Phosphorylation PhosphoSitePlus
K450 Ubiquitination PhosphoSitePlus
K455 Acetylation PhosphoSitePlus
K455 Ubiquitination PhosphoSitePlus
S461 Phosphorylation PhosphoSitePlus
R469 Methylation PhosphoSitePlus
Y485 Phosphorylation PhosphoSitePlus
Y486 Phosphorylation PhosphoSitePlus
S488 Phosphorylation PhosphoSitePlus
T493 Phosphorylation PhosphoSitePlus
K497 Ubiquitination PhosphoSitePlus
C499 S-Nitrosylation dbSNO 20140087, 22178444
S507 Phosphorylation PhosphoSitePlus
T509 Phosphorylation PhosphoSitePlus
S511 Phosphorylation PhosphoSitePlus
K521 Ubiquitination PhosphoSitePlus
Y533 Phosphorylation PhosphoSitePlus
K592 Acetylation PhosphoSitePlus   UniProt 19608861
K592 Ubiquitination PhosphoSitePlus
K604 Ubiquitination PhosphoSitePlus
S608 Phosphorylation PhosphoSitePlus
Y611 Phosphorylation PhosphoSitePlus
T612 Phosphorylation PhosphoSitePlus
T615 Phosphorylation PhosphoSitePlus
S621 Phosphorylation PhosphoSitePlus
K622 Acetylation PhosphoSitePlus
K622 Ubiquitination PhosphoSitePlus
K625 Acetylation PhosphoSitePlus   UniProt 19608861
K625 Ubiquitination PhosphoSitePlus
K632 Ubiquitination PhosphoSitePlus
S642 Phosphorylation PhosphoSitePlus
K643 Ubiquitination PhosphoSitePlus
S656 Phosphorylation PhosphoSitePlus
T667 Phosphorylation PhosphoSitePlus
T682 Phosphorylation PhosphoSitePlus
Y693 Phosphorylation PhosphoSitePlus
S696 Phosphorylation PhosphoSitePlus
Y700 Phosphorylation PhosphoSitePlus
K701 Ubiquitination PhosphoSitePlus
Y727 Phosphorylation PhosphoSitePlus
T741 Phosphorylation PhosphoSitePlus
T746 Phosphorylation PhosphoSitePlus
T756 Phosphorylation PhosphoSitePlus
K760 Ubiquitination PhosphoSitePlus
S763 Phosphorylation PhosphoSitePlus
S773 Phosphorylation PhosphoSitePlus
K779 Acetylation PhosphoSitePlus
K779 Methylation PhosphoSitePlus
K779 Ubiquitination PhosphoSitePlus
C793 S-Nitrosylation dbSNO 20140087, 22178444
S796 Phosphorylation PhosphoSitePlus
R805 Methylation PhosphoSitePlus
T839 Phosphorylation PhosphoSitePlus
T840 Phosphorylation PhosphoSitePlus
T842 Phosphorylation PhosphoSitePlus
T844 Phosphorylation PhosphoSitePlus
K853 Acetylation PhosphoSitePlus
K859 Acetylation PhosphoSitePlus
K859 Ubiquitination PhosphoSitePlus
R868 Methylation PhosphoSitePlus
Y878 Phosphorylation PhosphoSitePlus
Y886 Phosphorylation PhosphoSitePlus
Y898 Phosphorylation PhosphoSitePlus
K899 Acetylation PhosphoSitePlus
Y906 Phosphorylation PhosphoSitePlus
S909 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S159 Phosphorylation HPRD 20068231
Y265 Phosphorylation HPRD 18083107


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
Y13 C13 Biomuta DOID:1324 / lung cancer [ cosmic ]
K122 E122 Biomuta DOID:363 / uterine cancer [ tcga ]
T249 M249 Biomuta DOID:2531 / hematologic cancer [ icgc ]
S269 * Biomuta DOID:11934 / head and neck cancer [ tcga ]
R280 Q280 Biomuta DOID:363 / uterine cancer [ tcga ]
R310 L310 Biomuta DOID:3571 / liver cancer [ icgc ]
R319 C319 Biomuta DOID:1793 / pancreatic cancer [ tcga ] DOID:363 / uterine cancer [ tcga ]
R319 H319 Biomuta DOID:10534 / stomach cancer [ tcga ]
K323 N323 Biomuta DOID:3571 / liver cancer [ icgc ] DOID:1324 / lung cancer [ tcga ]
T359 M359 Biomuta DOID:363 / uterine cancer [ tcga ] DOID:10534 / stomach cancer [ cosmic, icgc, tcga ]
K421 N421 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
S423 C423 Biomuta DOID:1324 / lung cancer [ tcga ]
T445 A445 Biomuta DOID:1793 / pancreatic cancer [ icgc ] DOID:10283 / prostate cancer [ cosmic ]
S447 L447 Biomuta DOID:2531 / hematologic cancer [ icgc ]
R469 C469 Biomuta DOID:11054 / urinary bladder cancer [ tcga ]
Y486 * Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
T509 A509 Biomuta DOID:1793 / pancreatic cancer [ icgc ] DOID:0070003 / blastoma [ cosmic ]
T615 A615 Biomuta DOID:363 / uterine cancer [ cosmic, icgc, tcga ]
S621 Y621 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc, tcga ]
T667 N667 Biomuta DOID:1324 / lung cancer [ cosmic, icgc, tcga ]
T756 S756 Biomuta DOID:1324 / lung cancer [ cosmic ]
K760 N760 Biomuta DOID:3571 / liver cancer [ icgc ]
Y898 C898 Biomuta DOID:1612 / breast cancer [ tcga ]
K899 R899 Biomuta DOID:10534 / stomach cancer [ tcga ]