iPTMnet Report for O43684 (BUB3)
Protein Information
UniProt AC / UniProt ID | O43684 / BUB3_HUMAN |
Protein Name | Mitotic checkpoint protein BUB3 |
Gene Name | Name: BUB3 |
Organism | Homo sapiens (Human) |
PRO ID | PR:O43684 |
PRO Name | mitotic checkpoint protein BUB3 (human) |
Definition | A mitotic checkpoint protein BUB3 that is encoded in the genome of human. |
Short Label | hBUB3 |
Category | organism-gene |
O43684 (BUB3) as Substrate
Site | PTM Type | PTM Enzyme | Score | Source | PMID | |
---|---|---|---|---|---|---|
K8 | Acetylation | score1 | IEDB | 34357683 | ||
K8 | Sumoylation | score1 | PhosphoSitePlus | |||
K8 | Ubiquitination | score1 | PhosphoSitePlus | |||
S18 | Phosphorylation | PR:O43683 (hBUB1) | score2 | PRO | 20057499 | |
S19 | Phosphorylation | O43683 (BUB1) | score2 | PhosphoSitePlus | 20057499 | |
K21 | Ubiquitination | score1 | PhosphoSitePlus | |||
S33 | Phosphorylation | score1 | PhosphoSitePlus | |||
S48 | Phosphorylation | score1 | PhosphoSitePlus | |||
K52 | Ubiquitination | score1 | PhosphoSitePlus | |||
K80 | Ubiquitination | score1 | PhosphoSitePlus | |||
T86 | Phosphorylation | score1 | PhosphoSitePlus | |||
C101 | Methylation | score1 | IEDB | 31844290 | ||
C105 | Methylation | score1 | IEDB | 31844290 | ||
R126 | Methylation | score1 | PhosphoSitePlus | |||
T127 | Phosphorylation | score1 | PhosphoSitePlus | |||
C129 | Methylation | score1 | IEDB | 31844290 | ||
C129 | S-Nitrosylation | score0 | dbSNO | 2212679, 22126794, 26338901 | ||
T133 | O-Glycosylation | score1 | GlyGen | 23301498, 35008409, 33214551, ... | ||
T133 | Phosphorylation | score1 | PhosphoSitePlus | |||
S135 | Phosphorylation | score3 | PhosphoSitePlus RLIMS-P | 35085551 | ||
K139 | Ubiquitination | score1 | PhosphoSitePlus | |||
Y141 | Phosphorylation | score1 | PhosphoSitePlus | |||
S144 | Phosphorylation | score1 | PhosphoSitePlus | |||
R149 | Methylation | score1 | PhosphoSitePlus | |||
T154 | Phosphorylation | score1 | PhosphoSitePlus | |||
K179 | Acetylation | score2 | PhosphoSitePlus UniProt | 19608861 | ||
K179 | Ubiquitination | score1 | PhosphoSitePlus | |||
R186 | Methylation | score1 | PhosphoSitePlus | |||
K191 | Ubiquitination | score1 | PhosphoSitePlus | |||
Y194 | Phosphorylation | score1 | PhosphoSitePlus | |||
Y207 | Phosphorylation | P14618 (PKM) | score3 | PhosphoSitePlus RLIMS-P | 24316223 | |
S211 | Phosphorylation | score4 | phospho.ELM PhosphoSitePlus RLIMS-P UniProt | 30553276, 23186163, 15302935, ... | ||
K216 | Acetylation | score1 | PhosphoSitePlus | |||
K216 | Ubiquitination | score1 | PhosphoSitePlus | |||
K217 | Ubiquitination | score1 | PhosphoSitePlus | |||
K218 | Ubiquitination | score1 | PhosphoSitePlus | |||
K222 | Ubiquitination | score1 | PhosphoSitePlus | |||
K227 | Sumoylation | score1 | PhosphoSitePlus | |||
K227 | Ubiquitination | score1 | PhosphoSitePlus | |||
K266 | Ubiquitination | score1 | PhosphoSitePlus | |||
F284 | Methylation | score1 | IEDB | 32357974 | ||
K322 | Acetylation | score1 | PhosphoSitePlus | |||
K322 | Sumoylation | score1 | PhosphoSitePlus | |||
K322 | Ubiquitination | score1 | PhosphoSitePlus | |||
K324 | Ubiquitination | score1 | PhosphoSitePlus | |||
S325 | Phosphorylation | score2 | phospho.ELM PhosphoSitePlus | 22067460 | ||
C327 | S-Nitrosylation | score0 | dbSNO | 26338901 | ||
T328 | Phosphorylation | score1 | PhosphoSitePlus |
Proteoforms
PRO ID (Short Label) | Sites | PTM Enzyme | Source | PMID | |
---|---|---|---|---|---|
PR:000035437 (hBUB3/Phos:1) | pS18 | PR:O43683 (hBUB1) | PRO | 20057499 |
PTM-dependent PPI
PTM type | Substrate | Site | Interactant | Association type | Source | PMID | |
---|---|---|---|---|---|---|---|
Phosphorylation | O43684 (BUB3) | S211 | Q9NPF5 (DMAP1) | unknown | eFIP | 30553276 | |
Phosphorylation | Q9NPF5 (DMAP1) | Y246 | O43684 (BUB3) | inhibited_association | eFIP | 30553276 |
Proteoform PPIs
Protein 1 | Relation | Protein 2 | Source | PMID | |
---|---|---|---|---|---|
PR:O43683 (hBUB1) | Interaction | PR:O43684 (hBUB3) | PRO | 10198256, 15525512 | |
PR:O43684 (hBUB3) | Interaction | PR:O15350-2 (hTP73/iso:2) | PRO | 20057499 | |
PR:O43684 (hBUB3) | Interaction | PR:Q12834 (hCDC20) | PRO | ||
PR:O43684 (hBUB3) | Interaction | PR:O43683 (hBUB1) | PRO | 10198256 | |
PR:O43684 (hBUB3) | Interaction | PR:Q13257 (hMAD2L1) | PRO | ||
PR:O43684 (hBUB3) | Interaction | PR:P25054 (hAPC) | PRO | ||
PR:O43684 (hBUB3) | Interaction | PR:O60566 (hBUB1B) | PRO | 17785528 | |
PR:O43684 (hBUB3) | Interaction | PR:O15350-3 (hTP73/iso:3) | PRO | 20057499 | |
PR:O43684 (hBUB3) | Interaction | PR:Q9Y6D9 (hMAD1L1) | PRO | 10198256 | |
PR:O43684 (hBUB3) | Interaction | PR:O15350-5 (hTP73/iso:5) | PRO | 20057499 | |
PR:O43684 (hBUB3) | Interaction | PR:O15350-1 (hTP73/iso:1) | PRO | 20057499 | |
PR:O60566 (hBUB1B) | Interaction | PR:O43684 (hBUB3) | PRO | 20016069 | |
PR:P25054 (hAPC) | Interaction | PR:O43684 (hBUB3) | PRO | 11283619 | |
PR:Q13257 (hMAD2L1) | Interaction | PR:O43684 (hBUB3) | PRO | ||
PR:Q9Y6D9 (hMAD1L1) | Interaction | PR:O43684 (hBUB3) | PRO | 10198256 |
PTM sites affected in variants
Site | Variant | Source | PMID | Disease [Sample source] |
---|---|---|---|---|
S33 | Y33 | Biomuta | DOID:1793 / pancreatic cancer [ icgc ] DOID:10534 / stomach cancer [ cosmic, icgc ] DOID:1324 / lung cancer [ cosmic, icgc ] | |
R149 | W149 | Biomuta | DOID:9256 / colorectal cancer [ cosmic ] | |
T154 | P154 | Biomuta | DOID:1793 / pancreatic cancer [ icgc ] | |
K191 | E191 | Biomuta | DOID:10283 / prostate cancer [ cosmic, icgc ] | |
S211 | R211 | Biomuta | DOID:10534 / stomach cancer [ cosmic, icgc ] | |
K227 | N227 | Biomuta | DOID:9256 / colorectal cancer [ cosmic ] |