iPTMnet Report for O43663 (PRC1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID O43663 / PRC1_HUMAN
Protein Name Protein regulator of cytokinesis 1
Gene Name Name: PRC1
Organism Homo sapiens (Human)

PRO ID PR:O43663
DAG View
PRO Name protein regulator of cytokinesis 1 (human)
Definition A protein regulator of cytokinesis 1 that is encoded in the genome of human.
Short Label hPRC1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


O43663 (PRC1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S4 Phosphorylation PhosphoSitePlus
C14 Methylation IEDB 31844290
K17 Ubiquitination PhosphoSitePlus
K67 Ubiquitination PhosphoSitePlus
S70 Phosphorylation PhosphoSitePlus
K74 Ubiquitination PhosphoSitePlus
K101 Ubiquitination PhosphoSitePlus
T105 Phosphorylation PhosphoSitePlus
R111 Methylation PhosphoSitePlus
K178 Ubiquitination PhosphoSitePlus
S195 Phosphorylation phospho.ELM   PhosphoSitePlus 16565220
K229 Ubiquitination PhosphoSitePlus
R249 Methylation PhosphoSitePlus
T262 Phosphorylation PhosphoSitePlus
S265 Phosphorylation PhosphoSitePlus
S267 Phosphorylation PhosphoSitePlus
K268 Ubiquitination PhosphoSitePlus
K273 Ubiquitination PhosphoSitePlus
R281 Methylation PhosphoSitePlus
K286 Ubiquitination PhosphoSitePlus
K349 Ubiquitination PhosphoSitePlus
T379 Phosphorylation PhosphoSitePlus
K387 Sumoylation PhosphoSitePlus
K387 Ubiquitination PhosphoSitePlus
K390 Ubiquitination PhosphoSitePlus
K401 Sumoylation PhosphoSitePlus
K401 Ubiquitination PhosphoSitePlus
K419 Ubiquitination PhosphoSitePlus
K453 Acetylation PhosphoSitePlus
K456 Ubiquitination PhosphoSitePlus
Y464 Phosphorylation PhosphoSitePlus   RLIMS-P 33510346
S466 Phosphorylation PhosphoSitePlus
T470 Phosphorylation neXtProt   PhosphoSitePlus   RLIMS-P   UniProt 17351640, 9885575, 17438553, ...23186163, 22621898
S472 Phosphorylation PhosphoSitePlus
R475 Methylation PhosphoSitePlus
T481 Phosphorylation neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 17351640, 22621898, 17512944, ...17438553, 35449080, 26423135, 23940115, 16603632, 30992425, 23186163, 9885575, 16964243
T481 Phosphorylation P06493 (CDK1) PhosphoSitePlus 16603632, 17512944
T481 Phosphorylation Q00536 (CDK16) Signor 35449080
K484 Ubiquitination PhosphoSitePlus
K487 Ubiquitination PhosphoSitePlus
T509 Phosphorylation PhosphoSitePlus
Y511 Phosphorylation PhosphoSitePlus
S513 Phosphorylation PhosphoSitePlus   UniProt 20068231
S516 Phosphorylation PhosphoSitePlus
S521 Phosphorylation PhosphoSitePlus
S523 Phosphorylation PhosphoSitePlus
K524 Ubiquitination PhosphoSitePlus
S529 Phosphorylation PhosphoSitePlus
T530 Phosphorylation PhosphoSitePlus
S532 Phosphorylation PhosphoSitePlus
K534 Acetylation PhosphoSitePlus
T536 Phosphorylation PhosphoSitePlus
R541 Phosphorylation UniProt 18669648
S554 Phosphorylation PhosphoSitePlus
S557 Phosphorylation PhosphoSitePlus
Y560 Phosphorylation PhosphoSitePlus
S563 Phosphorylation PhosphoSitePlus
S571 Phosphorylation PhosphoSitePlus   UniProt 18669648, 23186163
S574 Phosphorylation PhosphoSitePlus
S577 Phosphorylation PhosphoSitePlus
T578 Phosphorylation PhosphoSitePlus   UniProt 17351640
S587 Phosphorylation PhosphoSitePlus
S589 Phosphorylation PhosphoSitePlus
S591 Phosphorylation PhosphoSitePlus
S592 Phosphorylation phospho.ELM   PhosphoSitePlus 16565220
T593 Phosphorylation PhosphoSitePlus
K602 Ubiquitination PhosphoSitePlus
K605 Ubiquitination PhosphoSitePlus
S615 Phosphorylation PhosphoSitePlus 17351640
S615 Phosphorylation P53350 (PLK1) PhosphoSitePlus 17351640
T616 Phosphorylation PhosphoSitePlus   UniProt 17351640, 24120663, 22621898
T616 Phosphorylation P53350 (PLK1) PhosphoSitePlus 22621898, 24120663
S620 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
T191 Phosphorylation HPRD 17081983
T194 Phosphorylation HPRD 20068231
S195 Phosphorylation HPRD 16565220
S265 Phosphorylation HPRD 19007248, 20068231, 19691289
S267 Phosphorylation HPRD 18452278
T470 Phosphorylation HPRD 9885575, 20068230
T470 Phosphorylation P24941 (CDK2) HPRD 9885575, 20068230
T481 Phosphorylation HPRD 18691976, 9885575, 18212344
T481 Phosphorylation P24941 (CDK2) HPRD 18691976, 9885575, 18212344
S501 Phosphorylation HPRD 19007248
S513 Phosphorylation HPRD 18691976, 19007248, 20068231, ...19691289
T536 Phosphorylation HPRD 20068231
Y560 Phosphorylation HPRD 20068231
S587 Phosphorylation HPRD 19691289
S589 Phosphorylation HPRD 19691289
S592 Phosphorylation HPRD 19691289, 16565220
S615 Phosphorylation HPRD 18691976
S620 Phosphorylation HPRD 18691976
Site PTM Type PTM Enzyme Score Source PMID
T440 Phosphorylation PhosphoSitePlus
T506 Phosphorylation PhosphoSitePlus
S541 Phosphorylation PhosphoSitePlus
S544 Phosphorylation PhosphoSitePlus
S550 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S513 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K17 N17 Biomuta DOID:10534 / stomach cancer [ cosmic ]
K67 N67 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
R111 * Biomuta DOID:363 / uterine cancer [ cosmic ] DOID:9256 / colorectal cancer [ cosmic ]
R111 Q111 Biomuta DOID:363 / uterine cancer [ icgc ]
K273 Q273 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
R281 W281 Biomuta DOID:4159 / skin cancer [ cosmic ]
T379 I379 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
K419 N419 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
R475 * Biomuta DOID:9256 / colorectal cancer [ cosmic ] DOID:10534 / stomach cancer [ cosmic ]
Y511 C511 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
S516 Y516 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S521 F521 Biomuta DOID:4362 / cervical cancer [ cosmic, icgc ]
Y560 C560 Biomuta DOID:4159 / skin cancer [ cosmic, icgc, tcga ]
S577 G577 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S589 P589 Biomuta DOID:4362 / cervical cancer [ cosmic ]
K602 N602 Biomuta DOID:10534 / stomach cancer [ cosmic ]