iPTMnet Report for O43660 (PLRG1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID O43660 / PLRG1_HUMAN
Protein Name Pleiotropic regulator 1
Gene Name Name: PLRG1
Organism Homo sapiens (Human)

PRO ID PR:O43660
DAG View
PRO Name pleiotropic regulator 1 (human)
Definition A pleiotropic regulator 1 that is encoded in the genome of human.
Short Label hPLRG1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


O43660 (PLRG1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
M1 Acetylation UniProt 19413330
K7 Acetylation PhosphoSitePlus
T12 Phosphorylation PhosphoSitePlus
K31 Acetylation PhosphoSitePlus
K31 Ubiquitination PhosphoSitePlus
K47 Ubiquitination PhosphoSitePlus
Y52 Phosphorylation PhosphoSitePlus
K62 Acetylation PhosphoSitePlus
K62 Ubiquitination PhosphoSitePlus
K68 Ubiquitination PhosphoSitePlus
K80 Ubiquitination PhosphoSitePlus
Y92 Phosphorylation PhosphoSitePlus
T97 O-Glycosylation GlyGen   PhosphoSitePlus 23584533
K113 Ubiquitination PhosphoSitePlus
S119 Phosphorylation O14757 (CHEK1) PhosphoSitePlus   UniProt 21851590, 23186163
S121 O-Glycosylation GlyGen 35008409, 30379171, 34725712, ...29351928, 34019948, 35254053
S121 Phosphorylation PhosphoSitePlus
S125 Phosphorylation PhosphoSitePlus
K135 Ubiquitination PhosphoSitePlus
S146 O-Glycosylation GlyGen 35008409, 30379171, 34725712, ...29351928, 34019948, 35254053
K173 Ubiquitination PhosphoSitePlus
S175 Phosphorylation PhosphoSitePlus
K180 Ubiquitination PhosphoSitePlus
T184 Phosphorylation PhosphoSitePlus
S201 Phosphorylation PhosphoSitePlus   UniProt 23186163
K229 Ubiquitination PhosphoSitePlus
K237 Ubiquitination PhosphoSitePlus
K268 Ubiquitination PhosphoSitePlus
K271 Ubiquitination PhosphoSitePlus
Y277 Phosphorylation PhosphoSitePlus
K279 Ubiquitination PhosphoSitePlus
K320 Ubiquitination PhosphoSitePlus
K363 Ubiquitination PhosphoSitePlus
K372 Ubiquitination PhosphoSitePlus
S389 Phosphorylation PhosphoSitePlus
S391 Phosphorylation PhosphoSitePlus   UniProt 23186163
K396 Ubiquitination PhosphoSitePlus
K484 Ubiquitination PhosphoSitePlus
K487 Ubiquitination PhosphoSitePlus
K505 Ubiquitination PhosphoSitePlus
K510 Ubiquitination PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
Y92 Phosphorylation HPRD 18452278
S119 Phosphorylation HPRD 20068231
S121 Phosphorylation HPRD 20068231


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K68 N68 Biomuta DOID:9253 / gastrointestinal stromal tumor [ cosmic ]
S121 * Biomuta DOID:11054 / urinary bladder cancer [ cosmic ]
S146 G146 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
K173 N173 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
T184 K184 Biomuta DOID:1319 / brain cancer [ cosmic, icgc ]
K279 N279 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S389 C389 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S391 C391 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
K510 N510 Biomuta DOID:8618 / oral cavity cancer [ cosmic ] DOID:11934 / head and neck cancer [ icgc ]