Protein Information

Cytoscape View


UniProt AC / UniProt ID O43639 / NCK2_HUMAN
Protein Name Cytoplasmic protein NCK2
Gene Name Name: NCK2
Synonyms:GRB4;
Organism Homo sapiens (Human)

PRO ID PR:O43639
DAG View
PRO Name cytoplasmic protein NCK2 (human)
Definition A cytoplasmic protein NCK2 that is encoded in the genome of human.
Short Label hNCK2
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


O43639 (NCK2) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
T2 Acetylation UniProt 22223895
T37 Phosphorylation PhosphoSitePlus
T48 Phosphorylation PhosphoSitePlus
Y50 Phosphorylation PhosphoSitePlus
S53 Phosphorylation PhosphoSitePlus
S61 Phosphorylation PhosphoSitePlus
S66 Phosphorylation PhosphoSitePlus
T74 Phosphorylation PhosphoSitePlus
S90 Phosphorylation HPRD   PhosphoSitePlus   UniProt 23186163, 19664994, 18452278, ...20166139, 15345747, 19690332
T92 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 18088087, 15345747, 23186163
S94 Phosphorylation PhosphoSitePlus
T95 Phosphorylation PhosphoSitePlus
Y99 Phosphorylation PhosphoSitePlus
S104 Phosphorylation PhosphoSitePlus
Y110 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 15570572, 18088087
S176 Phosphorylation PhosphoSitePlus
S187 Phosphorylation PhosphoSitePlus
S189 Phosphorylation PhosphoSitePlus
S270 Phosphorylation PhosphoSitePlus
Y271 Phosphorylation PhosphoSitePlus
S321 Phosphorylation PhosphoSitePlus
Y342 Phosphorylation PhosphoSitePlus


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation O15117 (FYB1) Y595 O43639 (NCK2) unknown eFIP 22074159
Phosphorylation P04626 (ERBB2) Y1196 O43639 (NCK2) unknown eFIP 16273093
Phosphorylation P09619 (PDGFRB) Y1009 O43639 (NCK2) unknown eFIP 11027258
Phosphorylation P21860 (ERBB3) Y1276 O43639 (NCK2) unknown eFIP 16273093
Phosphorylation P52799 (EFNB2) Y316 O43639 (NCK2) unknown eFIP 12606549
Phosphorylation P52799 (EFNB2) Y316 O43639 (NCK2) unknown eFIP 15764601
Phosphorylation Q08345 (DDR1) Y569 O43639 (NCK2) unknown eFIP 22057045
Phosphorylation Q15303 (ERBB4) Y1268 O43639 (NCK2) unknown eFIP 16729043


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
T92 M92 Biomuta DOID:363 / uterine cancer [ tcga ]
S94 N94 Biomuta DOID:3571 / liver cancer [ icgc ]
T95 M95 Biomuta DOID:363 / uterine cancer [ tcga ]
S176 C176 Biomuta DOID:1324 / lung cancer [ cosmic, icgc, tcga ]
S187 L187 Biomuta DOID:1324 / lung cancer [ tcga ]
S270 I270 Biomuta DOID:1324 / lung cancer [ cosmic ]