Protein Information

Cytoscape View

UniProt AC / UniProt ID O43633 / CHM2A_HUMAN
Protein Name Charged multivesicular body protein 2a
Gene Name Name: CHMP2A
Organism Homo sapiens (Human)

PRO ID PR:O43633
DAG View
PRO Name charged multivesicular body protein 2a (human)
Definition A charged multivesicular body protein 2a that is encoded in the genome of human.
Short Label hCHMP2A
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species

O43633 (CHMP2A) as Substrate

Site PTM Type PTM Enzyme Score Source PMID
M1 Acetylation UniProt 12665801
K9 Ubiquitination PhosphoSitePlus
T10 Phosphorylation PhosphoSitePlus
T38 Phosphorylation HPRD   PhosphoSitePlus 20068231
K52 Acetylation PhosphoSitePlus
K52 Ubiquitination PhosphoSitePlus
K64 Ubiquitination PhosphoSitePlus
S87 Phosphorylation PhosphoSitePlus
K89 Ubiquitination PhosphoSitePlus
T92 Phosphorylation PhosphoSitePlus
K94 Ubiquitination PhosphoSitePlus
S95 Phosphorylation PhosphoSitePlus
S98 Phosphorylation PhosphoSitePlus
K104 Ubiquitination PhosphoSitePlus
K108 Ubiquitination PhosphoSitePlus
K118 Ubiquitination PhosphoSitePlus
K124 Ubiquitination PhosphoSitePlus
S174 Phosphorylation PhosphoSitePlus
S180 Phosphorylation PhosphoSitePlus
S184 Phosphorylation PhosphoSitePlus   UniProt 24275569
T185 Phosphorylation PhosphoSitePlus   UniProt 24275569
S188 Phosphorylation PhosphoSitePlus   UniProt 24275569
S190 Phosphorylation PhosphoSitePlus   UniProt 24275569
K197 Ubiquitination PhosphoSitePlus
S203 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 23186163, 24275569, 16565220

PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
T92 I92 Biomuta DOID:363 / uterine cancer [ cosmic, icgc, tcga ]
S174 R174 Biomuta DOID:11934 / head and neck cancer [ tcga ]
S180 L180 Biomuta DOID:363 / uterine cancer [ icgc, tcga ] DOID:9256 / colorectal cancer [ tcga ] DOID:1909 / melanoma [ cosmic ]
S180 A180 Biomuta DOID:363 / uterine cancer [ icgc, tcga ]
S203 * Biomuta DOID:11054 / urinary bladder cancer [ tcga ]