Protein Information

Cytoscape View


UniProt AC / UniProt ID O43609 / SPY1_HUMAN
Protein Name Protein sprouty homolog 1
Gene Name Name: SPRY1
Organism Homo sapiens (Human)

PRO ID PR:O43609
DAG View
PRO Name protein sprouty homolog 1 (human)
Definition A protein sprouty homolog 1 that is encoded in the genome of human.
Short Label hSPRY1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


O43609 (SPRY1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
M1 Acetylation UniProt 22223895
K45 Ubiquitination PhosphoSitePlus
S50 Phosphorylation PhosphoSitePlus
Y53 Phosphorylation HPRD   phospho.ELM   PRO   PhosphoSitePlus 18083107, 17389395
T54 Phosphorylation PhosphoSitePlus
Y89 Phosphorylation PhosphoSitePlus
S112 Phosphorylation PhosphoSitePlus
S123 Phosphorylation PhosphoSitePlus
S131 Phosphorylation PhosphoSitePlus
S139 Phosphorylation PhosphoSitePlus
K167 Ubiquitination PhosphoSitePlus
S169 Phosphorylation PhosphoSitePlus
K171 Ubiquitination PhosphoSitePlus
Y304 Phosphorylation PhosphoSitePlus
K306 Ubiquitination PhosphoSitePlus


Proteoforms

PRO ID (Short Label) Sites PTM Enzyme Source PMID
PR:000049335 (hSPRY1/Phos:1) pY53 PRO


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
M1 V1 Biomuta DOID:10283 / prostate cancer [ cosmic, icgc ]
M1 I1 Biomuta DOID:3571 / liver cancer [ icgc ]
Y53 * Biomuta DOID:0070003 / blastoma [ cosmic ]
Y89 H89 Biomuta DOID:10534 / stomach cancer [ tcga ]
Y89 C89 Biomuta DOID:363 / uterine cancer [ cosmic, icgc, tcga ]
S123 F123 Biomuta DOID:2394 / ovarian cancer [ tcga ]
Y304 C304 Biomuta DOID:8618 / oral cavity cancer [ icgc ] DOID:3070 / malignant glioma [ tcga ]