iPTMnet Report for O43602 (DCX)


Protein Information

Cytoscape View


UniProt AC / UniProt ID O43602 / DCX_HUMAN
Protein Name Neuronal migration protein doublecortin
Gene Name Name: DCX
Synonyms:DBCN,LISX;
Organism Homo sapiens (Human)

PRO ID PR:O43602
DAG View
PRO Name neuronal migration protein doublecortin (human)
Definition A neuronal migration protein doublecortin that is encoded in the genome of human.
Short Label hDCX
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


O43602 (DCX) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S28 Phosphorylation PhosphoSitePlus
T30 Phosphorylation PhosphoSitePlus
S47 Phosphorylation PhosphoSitePlus   RLIMS-P 15632197, 32050972, 22367209
K50 Acetylation PhosphoSitePlus
K51 Acetylation PhosphoSitePlus
Y64 Phosphorylation PhosphoSitePlus
S74 Phosphorylation PhosphoSitePlus
Y103 Phosphorylation PhosphoSitePlus
Y105 Phosphorylation PhosphoSitePlus
S128 Phosphorylation P17612 (PRKACA) neXtProt 14741102
T203 Phosphorylation PhosphoSitePlus
S206 Phosphorylation PhosphoSitePlus
T222 Phosphorylation PhosphoSitePlus
S287 Phosphorylation PhosphoSitePlus
S297 Phosphorylation PhosphoSitePlus   RLIMS-P 32050972, 14741103, 15099191, ...15632197, 20715151
S306 Phosphorylation UniProt 22359282
S320 Phosphorylation PhosphoSitePlus
S325 Phosphorylation PhosphoSitePlus
S329 Phosphorylation PhosphoSitePlus
S332 Phosphorylation P49841 (GSK3B) PhosphoSitePlus   RLIMS-P   Signor 20715151, 21159948
S335 Phosphorylation PhosphoSitePlus
S339 Phosphorylation phospho.ELM   PhosphoSitePlus 15632197
K345 Acetylation PhosphoSitePlus
K347 Acetylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S28 Phosphorylation Q00535 (CDK5) HPRD 14741103
S287 Phosphorylation Q00535 (CDK5) HPRD 14741103
T289 Phosphorylation Q00535 (CDK5) HPRD 14741103
S297 Phosphorylation Q00535 (CDK5) HPRD 14741103
S306 Phosphorylation Q00535 (CDK5) HPRD 15345747, 14741103
S320 Phosphorylation HPRD 15345747
T326 Phosphorylation Q00535 (CDK5) HPRD 14741103
S332 Phosphorylation Q00535 (CDK5) HPRD 14741103
S335 Phosphorylation HPRD 17081983
T336 Phosphorylation Q00535 (CDK5) HPRD 14741103
S339 Phosphorylation Q00535 (CDK5) HPRD 14741103
Site PTM Type PTM Enzyme Score Source PMID
S28 Phosphorylation Q00535 (CDK5) HPRD 14741103
S287 Phosphorylation Q00535 (CDK5) HPRD 14741103
T289 Phosphorylation Q00535 (CDK5) HPRD 14741103
S297 Phosphorylation Q00535 (CDK5) HPRD 14741103
S306 Phosphorylation Q92630 (DYRK2) , Q00535 (CDK5) HPRD   PhosphoSitePlus 22359282, 15345747, 14741103
S315 Phosphorylation HPRD 15345747
T321 Phosphorylation Q00535 (CDK5) , P45984 (MAPK9) HPRD   neXtProt   PhosphoSitePlus 14765123, 14741103
S327 Phosphorylation P49841 (GSK3B) , Q00535 (CDK5) HPRD   PhosphoSitePlus 21159948, 14741103
S330 Phosphorylation HPRD 17081983
T331 Phosphorylation Q00535 (CDK5) , P45984 (MAPK9) HPRD   neXtProt   PhosphoSitePlus 14765123, 14741103
S334 Phosphorylation Q00535 (CDK5) , P45984 (MAPK9) HPRD   neXtProt   PhosphoSitePlus 14765123, 14741103
K340 Acetylation PhosphoSitePlus
K342 Acetylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S28 I28 Biomuta DOID:1324 / lung cancer [ cosmic ]
T30 N30 Biomuta DOID:1324 / lung cancer [ cosmic ]
K51 R51 Biomuta DOID:1324 / lung cancer [ cosmic ]
S74 C74 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc, cosmic ] DOID:4159 / skin cancer [ cosmic, icgc ] DOID:5158 / pleural cancer [ cosmic ] DOID:1324 / lung cancer [ cosmic, icgc, cosmic ]
S206 T206 Biomuta DOID:1324 / lung cancer [ cosmic ]
S287 F287 Biomuta DOID:1324 / lung cancer [ cosmic ]
S297 I297 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S297 N297 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S306 F306 Biomuta DOID:4159 / skin cancer [ cosmic ]
S315 A315 Biomuta DOID:1781 / thyroid gland cancer [ cosmic ]
S315 Y315 Biomuta DOID:8618 / oral cavity cancer [ cosmic ]
S315 F315 Biomuta [ cosmic ]
S320 A320 Biomuta DOID:1781 / thyroid gland cancer [ cosmic ]
S320 Y320 Biomuta DOID:8618 / oral cavity cancer [ cosmic ]
S320 F320 Biomuta [ cosmic ]
S329 F329 Biomuta DOID:8618 / oral cavity cancer [ cosmic ]
T331 M331 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ] DOID:1324 / lung cancer [ cosmic, icgc ] DOID:2531 / hematologic cancer [ cosmic ]
T336 M336 Biomuta DOID:9256 / colorectal cancer [ cosmic ] DOID:1324 / lung cancer [ cosmic ] DOID:2531 / hematologic cancer [ cosmic ]
K342 N342 Biomuta DOID:363 / uterine cancer [ icgc ] DOID:4159 / skin cancer [ cosmic, icgc ]
K347 N347 Biomuta DOID:4159 / skin cancer [ cosmic ]