iPTMnet Report for O43598 (DNPH1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID O43598 / DNPH1_HUMAN
Protein Name 2'-deoxynucleoside 5'-phosphate N-hydrolase 1
Gene Name Name: DNPH1
Synonyms:C6orf108,RCL;
Organism Homo sapiens (Human)

PRO ID PR:O43598
DAG View
PRO Name 2'-deoxynucleoside 5'-phosphate N-hydrolase 1 (human)
Definition A 2'-deoxynucleoside 5'-phosphate N-hydrolase 1 that is encoded in the genome of human.
Short Label hDNPH1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


O43598 (DNPH1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
A2 Acetylation UniProt 22814378, 22223895
S10 Phosphorylation PhosphoSitePlus
S12 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S28 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163
R30 Methylation PhosphoSitePlus
R36 Methylation PhosphoSitePlus
R41 Methylation PhosphoSitePlus
R48 Methylation PhosphoSitePlus
R65 Methylation PhosphoSitePlus
T95 Phosphorylation PhosphoSitePlus
S98 Phosphorylation PhosphoSitePlus   UniProt 24275569
K113 Ubiquitination PhosphoSitePlus
S123 Phosphorylation PhosphoSitePlus   UniProt 23186163
S128 Phosphorylation PhosphoSitePlus   UniProt 24275569
R132 Methylation PhosphoSitePlus
S138 Phosphorylation PhosphoSitePlus   UniProt 24275569
S169 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 21406692, 23186163, 17081983, ...18669648, 24275569, 17287340, 19690332, 20068231
T173 Phosphorylation PhosphoSitePlus
T174 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S12 Phosphorylation HPRD 18669648, 20068231
S28 Phosphorylation HPRD 18669648, 20068231
S128 Phosphorylation HPRD 20166139
S169 Phosphorylation HPRD 19413330, 17322306, 17287340, ...19664995, 18452278, 19651622, 18669648, 19415658, 20068231
Site PTM Type PTM Enzyme Score Source PMID
S12 Phosphorylation HPRD 18669648, 20068231
S28 Phosphorylation HPRD 18669648, 20068231


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S123 F123 Biomuta DOID:1324 / lung cancer [ cosmic ]
S128 L128 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
S169 F169 Biomuta DOID:4159 / skin cancer [ cosmic ]