Protein Information

Cytoscape View


UniProt AC / UniProt ID O43597 / SPY2_HUMAN
Protein Name Protein sprouty homolog 2
Gene Name Name: SPRY2
Organism Homo sapiens (Human)

PRO ID PR:O43597
DAG View
PRO Name protein sprouty homolog 2 (human)
Definition A protein sprouty homolog 2 that is encoded in the genome of human.
Short Label hSPRY2
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


O43597 (SPRY2) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S7 Phosphorylation PhosphoSitePlus
S11 Phosphorylation PhosphoSitePlus
T17 Phosphorylation PhosphoSitePlus
S42 Phosphorylation PhosphoSitePlus
Y55 Phosphorylation IntAct   phospho.ELM   PRO   PhosphoSitePlus   RLIMS-P   Signor 20622121, 12593795, 16000370, ...15564375, 15637081, 30160357, 16888801, 12815057, 16479008
Y55 Phosphorylation P12931 (SRC) phospho.ELM   PhosphoSitePlus   Signor 16479008, 15564375
T56 Phosphorylation PhosphoSitePlus   RLIMS-P 20877636
T75 Phosphorylation neXtProt   phospho.ELM   PhosphoSitePlus   Signor 20804972, 18678649
T75 Phosphorylation Q13627 (DYRK1A) neXtProt   phospho.ELM   PhosphoSitePlus   Signor 20804972, 18678649
K78 Methylation PhosphoSitePlus
S97 Phosphorylation PhosphoSitePlus
S112 Phosphorylation PRO   PhosphoSitePlus   RLIMS-P   Signor 16479008, 19864419
S112 Phosphorylation Q9BUB5 (MKNK1) PhosphoSitePlus   Signor 16479008, 19864419
S112 Phosphorylation Q9HBH9 (MKNK2) PhosphoSitePlus 19864419
S115 Phosphorylation PRO   PhosphoSitePlus
S116 Phosphorylation PhosphoSitePlus
S118 Phosphorylation PhosphoSitePlus
S121 Phosphorylation PRO   PhosphoSitePlus   RLIMS-P   Signor 16479008, 29635363, 19864419
S121 Phosphorylation Q9BUB5 (MKNK1) PhosphoSitePlus   Signor 16479008, 19864419
S121 Phosphorylation Q9HBH9 (MKNK2) PhosphoSitePlus 19864419
T124 Phosphorylation PhosphoSitePlus
S128 Phosphorylation PhosphoSitePlus
S131 Phosphorylation PhosphoSitePlus
S138 Phosphorylation PhosphoSitePlus
S139 Phosphorylation HPRD   PhosphoSitePlus 18578522
S141 Phosphorylation PhosphoSitePlus
S142 Phosphorylation PhosphoSitePlus
S156 Phosphorylation PhosphoSitePlus
K159 Ubiquitination PhosphoSitePlus
K164 Ubiquitination PhosphoSitePlus
S167 Phosphorylation PhosphoSitePlus
K168 Ubiquitination PhosphoSitePlus
Y176 Phosphorylation PhosphoSitePlus
T190 Phosphorylation PhosphoSitePlus
Y191 Phosphorylation PhosphoSitePlus
S197 Phosphorylation PhosphoSitePlus
S208 Phosphorylation PhosphoSitePlus
Y215 Phosphorylation PhosphoSitePlus
Y227 Phosphorylation phospho.ELM   PRO   PhosphoSitePlus   RLIMS-P 16888801, 15637081
Y269 Phosphorylation PhosphoSitePlus
Y283 Phosphorylation PhosphoSitePlus
S296 Phosphorylation PhosphoSitePlus
T298 Phosphorylation PhosphoSitePlus
T305 Phosphorylation PhosphoSitePlus
K313 Ubiquitination PhosphoSitePlus


Proteoforms

PRO ID (Short Label) Sites PTM Enzyme Source PMID
PR:000049337 (hSPRY2/Phos:3) pS112,pS115 PRO
PR:000049338 (hSPRY2/Phos:4) pS112,pS121 PRO
PR:000049339 (hSPRY2/Phos:5) pY55,pY227 PRO


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation O43597 (SPRY2) Y55 P22681 (CBL) unknown eFIP 12815057


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S11 L11 Biomuta DOID:1909 / melanoma [ icgc, tcga ]
T17 M17 Biomuta DOID:1909 / melanoma [ tcga ]
S42 Y42 Biomuta DOID:363 / uterine cancer [ tcga ] DOID:3070 / malignant glioma [ tcga ]
S97 * Biomuta DOID:1324 / lung cancer [ cosmic ]
S142 F142 Biomuta DOID:363 / uterine cancer [ tcga ]
Y191 F191 Biomuta DOID:1324 / lung cancer [ cosmic, tcga ]
S208 L208 Biomuta DOID:363 / uterine cancer [ tcga ]
S296 L296 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
S296 * Biomuta DOID:1324 / lung cancer [ tcga ]