iPTMnet Report for O43566 (RGS14)


Protein Information

Cytoscape View


UniProt AC / UniProt ID O43566 / RGS14_HUMAN
Protein Name Regulator of G-protein signaling 14
Gene Name Name: RGS14
Organism Homo sapiens (Human)

PRO ID PR:O43566
DAG View
PRO Name regulator of G-protein signaling 14 (human)
Definition A regulator of G-protein signaling 14 that is encoded in the genome of human.
Short Label hRGS14
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


O43566 (RGS14) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S20 Phosphorylation PhosphoSitePlus   UniProt 19690332
R37 Methylation PhosphoSitePlus
S40 Phosphorylation PhosphoSitePlus
S42 Phosphorylation PhosphoSitePlus   UniProt 19690332
S45 Phosphorylation PhosphoSitePlus   UniProt 19690332
S48 Phosphorylation PhosphoSitePlus
S52 Phosphorylation PhosphoSitePlus
S67 Phosphorylation PhosphoSitePlus
K86 Ubiquitination PhosphoSitePlus
K98 Ubiquitination PhosphoSitePlus
Y122 Phosphorylation PhosphoSitePlus
K176 Ubiquitination PhosphoSitePlus
S177 Phosphorylation PhosphoSitePlus
C183 Methylation IEDB 31844290
S199 Phosphorylation PhosphoSitePlus
S203 Phosphorylation PhosphoSitePlus
S218 Phosphorylation PhosphoSitePlus
S243 Phosphorylation IEDB   PhosphoSitePlus 27920218
T251 Phosphorylation PhosphoSitePlus
S260 Phosphorylation phospho.ELM   PhosphoSitePlus 12534294
S263 Phosphorylation PhosphoSitePlus
K287 Ubiquitination PhosphoSitePlus
S288 Phosphorylation PhosphoSitePlus
S291 Phosphorylation PhosphoSitePlus
T292 Phosphorylation PhosphoSitePlus
K302 Ubiquitination PhosphoSitePlus
S338 Phosphorylation PhosphoSitePlus
K422 Ubiquitination PhosphoSitePlus
K429 Ubiquitination PhosphoSitePlus
K448 Ubiquitination PhosphoSitePlus
T472 Phosphorylation PhosphoSitePlus
S478 Phosphorylation PhosphoSitePlus
S480 Phosphorylation PhosphoSitePlus
S481 Phosphorylation PhosphoSitePlus
K484 Ubiquitination PhosphoSitePlus
S487 Phosphorylation PhosphoSitePlus
T490 Phosphorylation PhosphoSitePlus
K492 Ubiquitination PhosphoSitePlus
T495 Phosphorylation PhosphoSitePlus
S510 Phosphorylation PhosphoSitePlus
K522 Ubiquitination PhosphoSitePlus
S539 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S67 Phosphorylation HPRD 20058876
S218 Phosphorylation HPRD 20058876
S260 Phosphorylation HPRD 12534294
S260 Phosphorylation P17612 (PRKACA) HPRD 12534294
T495 Phosphorylation HPRD 12534294
T495 Phosphorylation P17612 (PRKACA) HPRD 12534294


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
R37 H37 Biomuta DOID:5041 / esophageal cancer [ cosmic ]
R37 C37 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ] DOID:10534 / stomach cancer [ cosmic, icgc ]
S48 I48 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S48 C48 Biomuta DOID:3571 / liver cancer [ cosmic, icgc ]
S218 W218 Biomuta DOID:184 / bone cancer [ cosmic ]
K429 E429 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
K448 T448 Biomuta DOID:1324 / lung cancer [ cosmic ]
S481 F481 Biomuta DOID:4159 / skin cancer [ cosmic ]
K484 N484 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S539 G539 Biomuta DOID:4159 / skin cancer [ cosmic ]