iPTMnet Report for O43561 (LAT)
Protein Information
UniProt AC / UniProt ID | O43561 / LAT_HUMAN |
Protein Name | Linker for activation of T-cells family member 1 |
Gene Name | Name: LAT |
Organism | Homo sapiens (Human) |
PRO ID | PR:O43561 |
PRO Name | linker for activation of T-cells family member 1 (human) |
Definition | A linker for activation of T-cells family member 1 that is encoded in the genome of human. |
Short Label | hLAT |
Category | organism-gene |
O43561 (LAT) as Substrate
Site | PTM Type | PTM Enzyme | Score | Source | PMID | |
---|---|---|---|---|---|---|
S35 | Phosphorylation | score1 | PhosphoSitePlus | |||
Y36 | Phosphorylation | score1 | PhosphoSitePlus | |||
S38 | Phosphorylation | score2 | phospho.ELM PhosphoSitePlus | 15659558 | ||
T39 | Phosphorylation | score2 | phospho.ELM PhosphoSitePlus UniProt | 15659558, 18088087, 19690332 | ||
S40 | Phosphorylation | score2 | phospho.ELM PhosphoSitePlus UniProt | 15659558, 19690332 | ||
S41 | Phosphorylation | score2 | PhosphoSitePlus UniProt | 19690332 | ||
S43 | Phosphorylation | score2 | PhosphoSitePlus UniProt | 19690332 | ||
Y45 | Phosphorylation | score1 | PhosphoSitePlus | |||
K52 | Ubiquitination | score1 | PhosphoSitePlus | |||
Y64 | Phosphorylation | P06239 (LCK) | score2 | RLIMS-P+ | 27700984 | |
T68 | Phosphorylation | score1 | PhosphoSitePlus | |||
Y70 | Phosphorylation | score1 | PhosphoSitePlus | |||
S74 | Phosphorylation | score1 | PhosphoSitePlus | |||
S84 | Phosphorylation | score2 | phospho.ELM PhosphoSitePlus UniProt | 15659558, 18088087 | ||
S91 | Phosphorylation | score1 | PhosphoSitePlus | |||
T94 | Phosphorylation | score1 | PhosphoSitePlus | |||
S96 | Phosphorylation | score1 | PhosphoSitePlus | |||
S97 | Phosphorylation | score1 | PhosphoSitePlus | |||
S101 | Phosphorylation | score2 | phospho.ELM PhosphoSitePlus UniProt | 18088087, 19690332 | ||
S106 | Phosphorylation | score2 | PhosphoSitePlus UniProt | 19690332 | ||
S109 | Phosphorylation | score2 | phospho.ELM PhosphoSitePlus | 18088087 | ||
Y110 | Phosphorylation | score1 | PhosphoSitePlus | |||
S131 | Phosphorylation | score1 | PhosphoSitePlus | |||
Y156 | Phosphorylation | P43403 (ZAP70) | score3 | PRO PhosphoSitePlus Signor | 11368773 | |
Y161 | Phosphorylation | P43403 (ZAP70) | score4 | IntAct PRO PhosphoSitePlus Signor | 11368773, 10811803 | |
S173 | O-Glycosylation | score1 | GlyGen | 29351928 | ||
S178 | O-Glycosylation | score1 | GlyGen | 29351928 | ||
S183 | Phosphorylation | score1 | PhosphoSitePlus | |||
T184 | Phosphorylation | P27361 (MAPK3) , P45983 (MAPK8) | score3 | neXtProt PhosphoSitePlus Signor | 15192708 | |
Y200 | Phosphorylation | P06239 (LCK) , P43403 (ZAP70) , Q08881 (ITK) , P06241 (FYN) | score4 | IntAct neXtProt PRO PhosphoSitePlus Signor UniProt | 12186560, 10811803, 9489702, ... | |
S206 | Phosphorylation | score1 | PhosphoSitePlus | |||
S213 | Phosphorylation | score1 | PhosphoSitePlus | |||
S217 | Phosphorylation | score1 | PhosphoSitePlus | |||
Y220 | Phosphorylation | P06241 (FYN) , P43403 (ZAP70) , P06239 (LCK) , Q08881 (ITK) | score4 | IntAct neXtProt phospho.ELM PRO PhosphoSitePlus Signor | 15659558, 12186560, 10811803, ... | |
S224 | Phosphorylation | score2 | phospho.ELM PhosphoSitePlus UniProt | 15659558, 18088087 | ||
S240 | Phosphorylation | score2 | PhosphoSitePlus UniProt | 19690332 | ||
S241 | Phosphorylation | score2 | PhosphoSitePlus UniProt | 19690332 | ||
Y255 | Phosphorylation | P43403 (ZAP70) | score4 | PRO PhosphoSitePlus Signor UniProt | 11368773, 19690332 |
Site | PTM Type | PTM Enzyme | Score | Source | PMID | |
---|---|---|---|---|---|---|
T39 | Phosphorylation | score0 | HPRD | 18088087 | ||
S40 | Phosphorylation | score0 | HPRD | 15144186 | ||
S84 | Phosphorylation | score0 | HPRD | 15659558, 18088087 | ||
S101 | Phosphorylation | score0 | HPRD | 18088087 | ||
S109 | Phosphorylation | score0 | HPRD | 18088087 | ||
Y156 | Phosphorylation | P43403 (ZAP70) | score1 | HPRD | 11368773 | |
Y161 | Phosphorylation | P43403 (ZAP70) | score1 | HPRD | 11368773 | |
Y200 | Phosphorylation | P43403 (ZAP70) | score1 | HPRD | 11368773 | |
Y220 | Phosphorylation | P43403 (ZAP70) | score1 | HPRD | 11368773 | |
S224 | Phosphorylation | score0 | HPRD | 15659558, 18088087 | ||
Y255 | Phosphorylation | P43403 (ZAP70) | score1 | HPRD | 11368773 |
Site | PTM Type | PTM Enzyme | Score | Source | PMID | |
---|---|---|---|---|---|---|
T39 | Phosphorylation | score0 | HPRD | 18088087 | ||
S40 | Phosphorylation | score0 | HPRD | 15144186 | ||
K52 | Ubiquitination | score1 | PhosphoSitePlus | |||
S84 | Phosphorylation | score0 | HPRD | 15659558, 18088087 | ||
Y110 | Phosphorylation | score1 | PhosphoSitePlus | |||
Y127 | Phosphorylation | P43403 (ZAP70) | score3 | HPRD neXtProt PhosphoSitePlus | 11368773 | |
Y132 | Phosphorylation | P43403 (ZAP70) | score3 | HPRD neXtProt PhosphoSitePlus | 11368773 | |
T155 | Phosphorylation | P27361 (MAPK3) , P45983 (MAPK8) | score2 | PhosphoSitePlus | 15192708 | |
Y171 | Phosphorylation | P43403 (ZAP70) | score4 | HPRD IntAct neXtProt PhosphoSitePlus | 16906159, 16938345, 11368773 | |
Y191 | Phosphorylation | P43403 (ZAP70) | score4 | HPRD IntAct neXtProt PhosphoSitePlus | 16906159, 16938345, 11368773 | |
S195 | Phosphorylation | score0 | HPRD | 15659558, 18088087 | ||
K204 | Ubiquitination | score1 | PhosphoSitePlus | |||
Y226 | Phosphorylation | P43403 (ZAP70) | score4 | HPRD IntAct neXtProt PhosphoSitePlus | 16906159, 11368773 |
Site | PTM Type | PTM Enzyme | Score | Source | PMID | |
---|---|---|---|---|---|---|
S29 | Phosphorylation | score1 | PhosphoSitePlus | |||
T75 | Phosphorylation | score0 | HPRD | 18088087 | ||
S76 | Phosphorylation | score0 | HPRD | 15144186 | ||
S120 | Phosphorylation | score0 | HPRD | 15659558, 18088087 | ||
Y163 | Phosphorylation | P43403 (ZAP70) | score1 | HPRD | 11368773 | |
Y168 | Phosphorylation | P43403 (ZAP70) | score1 | HPRD | 11368773 | |
Y207 | Phosphorylation | P43403 (ZAP70) | score2 | HPRD | 16938345, 11368773 | |
Y227 | Phosphorylation | P43403 (ZAP70) | score2 | HPRD | 16938345, 11368773 | |
S231 | Phosphorylation | score0 | HPRD | 15659558, 18088087 | ||
Y262 | Phosphorylation | P43403 (ZAP70) | score1 | HPRD | 11368773 |
Site | PTM Type | PTM Enzyme | Score | Source | PMID | |
---|---|---|---|---|---|---|
T39 | Phosphorylation | score0 | HPRD | 18088087 | ||
S40 | Phosphorylation | score0 | HPRD | 15144186 | ||
S83 | Phosphorylation | score2 | HPRD PhosphoSitePlus | 15659558 | ||
Y126 | Phosphorylation | P43403 (ZAP70) | score1 | HPRD | 11368773 | |
Y131 | Phosphorylation | P43403 (ZAP70) | score1 | HPRD | 11368773 | |
Y170 | Phosphorylation | P43403 (ZAP70) | score1 | HPRD | 11368773 | |
Y190 | Phosphorylation | P43403 (ZAP70) | score1 | HPRD | 11368773 | |
S194 | Phosphorylation | score0 | HPRD | 15659558, 18088087 | ||
Y225 | Phosphorylation | P43403 (ZAP70) | score1 | HPRD | 11368773 |
Proteoforms
PRO ID (Short Label) | Sites | PTM Enzyme | Source | PMID | |
---|---|---|---|---|---|
PR:000048167 (hLAT/Phos:1) | pY156,pY161,pY200,pY220,pY255 | PRO | |||
PR:000048168 (hLAT/Phos:2) | pY200,pY220 | PRO |
PTM sites affected in variants
Site | Variant | Source | PMID | Disease [Sample source] |
---|---|---|---|---|
S83 | F83 | Biomuta | DOID:4159 / skin cancer [ cosmic, icgc ] | |
S84 | F84 | Biomuta | DOID:4159 / skin cancer [ cosmic, icgc ] | |
S91 | F91 | Biomuta | DOID:4159 / skin cancer [ cosmic ] | |
T94 | M94 | Biomuta | DOID:8618 / oral cavity cancer [ cosmic ] DOID:9256 / colorectal cancer [ cosmic ] DOID:9253 / gastrointestinal stromal tumor [ cosmic ] DOID:11934 / head and neck cancer [ icgc ] | |
S97 | F97 | Biomuta | DOID:4159 / skin cancer [ cosmic, icgc ] | |
S106 | I106 | Biomuta | [ cosmic ] DOID:1115 / sarcoma [ icgc ] | |
S120 | F120 | Biomuta | DOID:4159 / skin cancer [ cosmic, icgc ] | |
S194 | P194 | Biomuta | DOID:4159 / skin cancer [ cosmic ] | |
S195 | P195 | Biomuta | DOID:4159 / skin cancer [ cosmic, cosmic, icgc ] | |
S224 | P224 | Biomuta | DOID:4159 / skin cancer [ cosmic ] | |
S231 | P231 | Biomuta | DOID:4159 / skin cancer [ cosmic ] |