iPTMnet Report for O43561 (LAT)


Protein Information

Cytoscape View


UniProt AC / UniProt ID O43561 / LAT_HUMAN
Protein Name Linker for activation of T-cells family member 1
Gene Name Name: LAT
Organism Homo sapiens (Human)

PRO ID PR:O43561
DAG View
PRO Name linker for activation of T-cells family member 1 (human)
Definition A linker for activation of T-cells family member 1 that is encoded in the genome of human.
Short Label hLAT
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


O43561 (LAT) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S35 Phosphorylation PhosphoSitePlus
Y36 Phosphorylation PhosphoSitePlus
S38 Phosphorylation phospho.ELM   PhosphoSitePlus 15659558
T39 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 15659558, 18088087, 19690332
S40 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 15659558, 19690332
S41 Phosphorylation PhosphoSitePlus   UniProt 19690332
S43 Phosphorylation PhosphoSitePlus   UniProt 19690332
Y45 Phosphorylation PhosphoSitePlus
K52 Ubiquitination PhosphoSitePlus
Y64 Phosphorylation P06239 (LCK) RLIMS-P+ 27700984
T68 Phosphorylation PhosphoSitePlus
Y70 Phosphorylation PhosphoSitePlus
S74 Phosphorylation PhosphoSitePlus
S84 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 15659558, 18088087
S91 Phosphorylation PhosphoSitePlus
T94 Phosphorylation PhosphoSitePlus
S96 Phosphorylation PhosphoSitePlus
S97 Phosphorylation PhosphoSitePlus
S101 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18088087, 19690332
S106 Phosphorylation PhosphoSitePlus   UniProt 19690332
S109 Phosphorylation phospho.ELM   PhosphoSitePlus 18088087
Y110 Phosphorylation PhosphoSitePlus
S131 Phosphorylation PhosphoSitePlus
Y156 Phosphorylation P43403 (ZAP70) PRO   PhosphoSitePlus   Signor 11368773
Y161 Phosphorylation P43403 (ZAP70) IntAct   PRO   PhosphoSitePlus   Signor 11368773, 10811803
S173 O-Glycosylation GlyGen 29351928
S178 O-Glycosylation GlyGen 29351928
S183 Phosphorylation PhosphoSitePlus
T184 Phosphorylation P27361 (MAPK3) , P45983 (MAPK8) neXtProt   PhosphoSitePlus   Signor 15192708
Y200 Phosphorylation P06239 (LCK) , P43403 (ZAP70) , Q08881 (ITK) , P06241 (FYN) IntAct   neXtProt   PRO   PhosphoSitePlus   Signor   UniProt 12186560, 10811803, 9489702, ...16938345, 11368773, 15029250
S206 Phosphorylation PhosphoSitePlus
S213 Phosphorylation PhosphoSitePlus
S217 Phosphorylation PhosphoSitePlus
Y220 Phosphorylation P06241 (FYN) , P43403 (ZAP70) , P06239 (LCK) , Q08881 (ITK) IntAct   neXtProt   phospho.ELM   PRO   PhosphoSitePlus   Signor 15659558, 12186560, 10811803, ...9489702, 16938345, 11368773, 15029250
S224 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 15659558, 18088087
S240 Phosphorylation PhosphoSitePlus   UniProt 19690332
S241 Phosphorylation PhosphoSitePlus   UniProt 19690332
Y255 Phosphorylation P43403 (ZAP70) PRO   PhosphoSitePlus   Signor   UniProt 11368773, 19690332
Site PTM Type PTM Enzyme Score Source PMID
T39 Phosphorylation HPRD 18088087
S40 Phosphorylation HPRD 15144186
S84 Phosphorylation HPRD 15659558, 18088087
S101 Phosphorylation HPRD 18088087
S109 Phosphorylation HPRD 18088087
Y156 Phosphorylation P43403 (ZAP70) HPRD 11368773
Y161 Phosphorylation P43403 (ZAP70) HPRD 11368773
Y200 Phosphorylation P43403 (ZAP70) HPRD 11368773
Y220 Phosphorylation P43403 (ZAP70) HPRD 11368773
S224 Phosphorylation HPRD 15659558, 18088087
Y255 Phosphorylation P43403 (ZAP70) HPRD 11368773
Site PTM Type PTM Enzyme Score Source PMID
T39 Phosphorylation HPRD 18088087
S40 Phosphorylation HPRD 15144186
K52 Ubiquitination PhosphoSitePlus
S84 Phosphorylation HPRD 15659558, 18088087
Y110 Phosphorylation PhosphoSitePlus
Y127 Phosphorylation P43403 (ZAP70) HPRD   neXtProt   PhosphoSitePlus 11368773
Y132 Phosphorylation P43403 (ZAP70) HPRD   neXtProt   PhosphoSitePlus 11368773
T155 Phosphorylation P27361 (MAPK3) , P45983 (MAPK8) PhosphoSitePlus 15192708
Y171 Phosphorylation P43403 (ZAP70) HPRD   IntAct   neXtProt   PhosphoSitePlus 16906159, 16938345, 11368773
Y191 Phosphorylation P43403 (ZAP70) HPRD   IntAct   neXtProt   PhosphoSitePlus 16906159, 16938345, 11368773
S195 Phosphorylation HPRD 15659558, 18088087
K204 Ubiquitination PhosphoSitePlus
Y226 Phosphorylation P43403 (ZAP70) HPRD   IntAct   neXtProt   PhosphoSitePlus 16906159, 11368773
Site PTM Type PTM Enzyme Score Source PMID
S29 Phosphorylation PhosphoSitePlus
T75 Phosphorylation HPRD 18088087
S76 Phosphorylation HPRD 15144186
S120 Phosphorylation HPRD 15659558, 18088087
Y163 Phosphorylation P43403 (ZAP70) HPRD 11368773
Y168 Phosphorylation P43403 (ZAP70) HPRD 11368773
Y207 Phosphorylation P43403 (ZAP70) HPRD 16938345, 11368773
Y227 Phosphorylation P43403 (ZAP70) HPRD 16938345, 11368773
S231 Phosphorylation HPRD 15659558, 18088087
Y262 Phosphorylation P43403 (ZAP70) HPRD 11368773
Site PTM Type PTM Enzyme Score Source PMID
T39 Phosphorylation HPRD 18088087
S40 Phosphorylation HPRD 15144186
S83 Phosphorylation HPRD   PhosphoSitePlus 15659558
Y126 Phosphorylation P43403 (ZAP70) HPRD 11368773
Y131 Phosphorylation P43403 (ZAP70) HPRD 11368773
Y170 Phosphorylation P43403 (ZAP70) HPRD 11368773
Y190 Phosphorylation P43403 (ZAP70) HPRD 11368773
S194 Phosphorylation HPRD 15659558, 18088087
Y225 Phosphorylation P43403 (ZAP70) HPRD 11368773


Proteoforms

PRO ID (Short Label) Sites PTM Enzyme Source PMID
PR:000048167 (hLAT/Phos:1) pY156,pY161,pY200,pY220,pY255 PRO
PR:000048168 (hLAT/Phos:2) pY200,pY220 PRO


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S83 F83 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S84 F84 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S91 F91 Biomuta DOID:4159 / skin cancer [ cosmic ]
T94 M94 Biomuta DOID:8618 / oral cavity cancer [ cosmic ] DOID:9256 / colorectal cancer [ cosmic ] DOID:9253 / gastrointestinal stromal tumor [ cosmic ] DOID:11934 / head and neck cancer [ icgc ]
S97 F97 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S106 I106 Biomuta [ cosmic ] DOID:1115 / sarcoma [ icgc ]
S120 F120 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S194 P194 Biomuta DOID:4159 / skin cancer [ cosmic ]
S195 P195 Biomuta DOID:4159 / skin cancer [ cosmic, cosmic, icgc ]
S224 P224 Biomuta DOID:4159 / skin cancer [ cosmic ]
S231 P231 Biomuta DOID:4159 / skin cancer [ cosmic ]