iPTMnet Report for O43526 (KCNQ2)


Protein Information

Cytoscape View


UniProt AC / UniProt ID O43526 / KCNQ2_HUMAN
Protein Name Potassium voltage-gated channel subfamily KQT member 2
Gene Name Name: KCNQ2
Organism Homo sapiens (Human)

PRO ID PR:O43526
DAG View
PRO Name potassium voltage-gated channel subfamily KQT member 2 (human)
Definition A voltage-gated potassium channel subunit KCNQ2 that is encoded in the genome of human.
Short Label hKCNQ2
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


O43526 (KCNQ2) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K21 Ubiquitination PhosphoSitePlus
K49 Ubiquitination PhosphoSitePlus
S52 Phosphorylation PhosphoSitePlus   UniProt 9872318
K69 Acetylation IEDB 34357683
Y74 Phosphorylation IEDB 35494241
T217 Phosphorylation PhosphoSitePlus   UniProt 16319223
S229 Phosphorylation PhosphoSitePlus
Y237 Phosphorylation PhosphoSitePlus
Y372 Phosphorylation PhosphoSitePlus
Y379 Phosphorylation PhosphoSitePlus
K398 Acetylation PhosphoSitePlus
S414 Phosphorylation PhosphoSitePlus
S438 Phosphorylation PhosphoSitePlus
S445 Phosphorylation PhosphoSitePlus
S476 Phosphorylation PhosphoSitePlus
S507 Phosphorylation PhosphoSitePlus
K556 Methylation PhosphoSitePlus
Y562 Phosphorylation PhosphoSitePlus
Y571 Phosphorylation PhosphoSitePlus
Y644 Phosphorylation PhosphoSitePlus
Y658 Phosphorylation PhosphoSitePlus
Y755 Phosphorylation PhosphoSitePlus
S762 Phosphorylation PhosphoSitePlus
Y821 Phosphorylation PhosphoSitePlus
S843 Phosphorylation PhosphoSitePlus
S855 Phosphorylation PhosphoSitePlus
T857 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S551 Phosphorylation P17252 (PRKCA) HPRD 12754513
S558 Phosphorylation P17252 (PRKCA) HPRD 12754513
Site PTM Type PTM Enzyme Score Source PMID
S533 Phosphorylation P17252 (PRKCA) HPRD 12754513
S540 Phosphorylation P17252 (PRKCA) HPRD 12754513
Site PTM Type PTM Enzyme Score Source PMID
Y372 Phosphorylation PhosphoSitePlus
S511 Phosphorylation PhosphoSitePlus
S523 Phosphorylation P17252 (PRKCA) HPRD 12754513
S530 Phosphorylation P17252 (PRKCA) HPRD 12754513
Site PTM Type PTM Enzyme Score Source PMID
S52 Phosphorylation PhosphoSitePlus
S414 Phosphorylation PhosphoSitePlus
S427 Phosphorylation PhosphoSitePlus
S436 Phosphorylation PhosphoSitePlus
S438 Phosphorylation PhosphoSitePlus
S446 Phosphorylation PhosphoSitePlus
S455 Phosphorylation PhosphoSitePlus
S477 Phosphorylation PhosphoSitePlus
S520 Phosphorylation P17252 (PRKCA) HPRD 12754513
S527 Phosphorylation P17252 (PRKCA) HPRD 12754513
S641 Phosphorylation PhosphoSitePlus
S700 Phosphorylation PhosphoSitePlus
S731 Phosphorylation PhosphoSitePlus
S772 Phosphorylation PhosphoSitePlus
S779 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S229 R229 Biomuta DOID:4606 / bile duct cancer [ cosmic ]
Y379 * Biomuta DOID:1612 / breast cancer [ cosmic ]
S445 F445 Biomuta DOID:4159 / skin cancer [ cosmic ]
S445 Y445 Biomuta DOID:5041 / esophageal cancer [ cosmic ]
S641 N641 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S772 R772 Biomuta DOID:1324 / lung cancer [ cosmic ]
S855 L855 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ] DOID:10534 / stomach cancer [ cosmic ]