iPTMnet Report for O43525 (KCNQ3)


Protein Information

Cytoscape View


UniProt AC / UniProt ID O43525 / KCNQ3_HUMAN
Protein Name Potassium voltage-gated channel subfamily KQT member 3
Gene Name Name: KCNQ3
Organism Homo sapiens (Human)

PRO ID PR:O43525
DAG View
PRO Name potassium voltage-gated channel subfamily KQT member 3 (human)
Definition A voltage-gated potassium channel subunit KCNQ3 that is encoded in the genome of human.
Short Label hKCNQ3
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


O43525 (KCNQ3) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
Y125 Phosphorylation PhosphoSitePlus
Y184 Phosphorylation PhosphoSitePlus
T246 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 16319223
Y481 Phosphorylation PhosphoSitePlus
Y502 Phosphorylation PhosphoSitePlus
T573 Phosphorylation PhosphoSitePlus
S578 Phosphorylation phospho.ELM   PhosphoSitePlus 16319223
T579 Phosphorylation phospho.ELM   PhosphoSitePlus 16319223
T655 O-Glycosylation GlyGen 28657654, 25303527
T663 Phosphorylation PhosphoSitePlus
S664 Phosphorylation PhosphoSitePlus
S665 Phosphorylation PhosphoSitePlus
T746 Phosphorylation PhosphoSitePlus
Y770 Phosphorylation PhosphoSitePlus
S771 Phosphorylation PhosphoSitePlus
S810 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
Y125 Phosphorylation HPRD 20058876
T746 Phosphorylation HPRD 17924679


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
Y125 N125 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
Y184 C184 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
Y502 H502 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
T573 S573 Biomuta DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ]
T579 M579 Biomuta DOID:3565 / meningioma [ cosmic ]
T655 M655 Biomuta DOID:4159 / skin cancer [ cosmic ] DOID:1612 / breast cancer [ cosmic, icgc ]
T663 I663 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S665 L665 Biomuta [ cosmic ]
S771 L771 Biomuta DOID:363 / uterine cancer [ cosmic ] DOID:2394 / ovarian cancer [ cosmic ] DOID:4159 / skin cancer [ cosmic ]