Protein Information

Cytoscape View


UniProt AC / UniProt ID O43520 / AT8B1_HUMAN
Protein Name Phospholipid-transporting ATPase IC
Gene Name Name: ATP8B1
Synonyms:ATPIC,FIC1,PFIC;
Organism Homo sapiens (Human)

PRO ID PR:O43520
DAG View
PRO Name phospholipid-transporting ATPase IC (human)
Definition A phospholipid-transporting ATPase IC that is encoded in the genome of human.
Short Label hATP8B1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


O43520 (ATP8B1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S38 Phosphorylation PhosphoSitePlus
K60 Methylation PhosphoSitePlus
T440 Phosphorylation PhosphoSitePlus
Y476 Phosphorylation PhosphoSitePlus
K615 Methylation PhosphoSitePlus
Y658 Phosphorylation PhosphoSitePlus
T667 Phosphorylation PhosphoSitePlus
Y779 Phosphorylation PhosphoSitePlus
S789 Phosphorylation PhosphoSitePlus
K902 Acetylation PhosphoSitePlus
Y924 Phosphorylation PhosphoSitePlus
S925 Phosphorylation PhosphoSitePlus
Y992 Phosphorylation PhosphoSitePlus
S1203 Phosphorylation PhosphoSitePlus
T1204 Phosphorylation PhosphoSitePlus
S1207 Phosphorylation PhosphoSitePlus
Y1209 Phosphorylation PhosphoSitePlus
Y1217 Phosphorylation PhosphoSitePlus
S1232 Phosphorylation PhosphoSitePlus
T1242 Phosphorylation PhosphoSitePlus
Y1245 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
Y658 D658 Biomuta DOID:2394 / ovarian cancer [ tcga ]
Y779 * Biomuta DOID:3571 / liver cancer [ icgc ]
Y924 D924 Biomuta DOID:1909 / melanoma [ cosmic ]
Y992 * Biomuta DOID:263 / kidney cancer [ cosmic, icgc ]
T1204 M1204 Biomuta DOID:363 / uterine cancer [ tcga ]
S1232 L1232 Biomuta DOID:1909 / melanoma [ cosmic ]