iPTMnet Report for O43516 (WIPF1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID O43516 / WIPF1_HUMAN
Protein Name WAS/WASL-interacting protein family member 1
Gene Name Name: WIPF1
Synonyms:WASPIP,WIP;
Organism Homo sapiens (Human)

PRO ID PR:O43516
DAG View
PRO Name WAS/WASL-interacting protein family member 1 (human)
Definition A WAS/WASL-interacting protein family member 1 that is encoded in the genome of human.
Short Label hWIPF1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


O43516 (WIPF1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
R33 Methylation PhosphoSitePlus
S91 Phosphorylation PhosphoSitePlus
R125 Methylation PhosphoSitePlus
R134 Methylation PhosphoSitePlus
S135 Phosphorylation PhosphoSitePlus
S142 Phosphorylation PhosphoSitePlus
S145 Phosphorylation PhosphoSitePlus
R149 Methylation PhosphoSitePlus
S154 Phosphorylation PhosphoSitePlus
S203 Phosphorylation PhosphoSitePlus
R211 Methylation PhosphoSitePlus
S214 Phosphorylation PhosphoSitePlus
T218 Phosphorylation PhosphoSitePlus
R226 Methylation PhosphoSitePlus
S234 Phosphorylation PhosphoSitePlus   RLIMS-P   UniProt 23186163, 25413351
R236 Methylation PhosphoSitePlus
S238 Phosphorylation PhosphoSitePlus
S241 Phosphorylation PhosphoSitePlus
S244 Phosphorylation PhosphoSitePlus
S247 Phosphorylation PhosphoSitePlus
R249 Methylation PhosphoSitePlus
T255 Phosphorylation PhosphoSitePlus
R258 Methylation PhosphoSitePlus
S276 Phosphorylation PhosphoSitePlus
S325 O-Glycosylation GlyGen 29485866, 31492838, 29351928, ...35254053
S340 Phosphorylation PhosphoSitePlus   UniProt 23186163, 20068231, 24275569
S342 Phosphorylation PhosphoSitePlus   RLIMS-P 25413351
S344 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
T345 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 20068231
S350 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 23186163, 18220336, 18669648, ...19690332, 20068231
S386 O-Glycosylation GlyGen 29485866, 31492838, 32938750, ...29351928, 35254053
T398 Phosphorylation PhosphoSitePlus
R404 Methylation PhosphoSitePlus
R415 Methylation PhosphoSitePlus
R422 Methylation PhosphoSitePlus
S444 Phosphorylation PhosphoSitePlus
Y455 Phosphorylation RLIMS-P 25413351
Y468 Phosphorylation RLIMS-P 25413351
S488 Phosphorylation Q04759 (PRKCQ) phospho.ELM   PhosphoSitePlus   RLIMS-P 17711847, 12504004, 16460447, ...26453379, 25413351
R493 Methylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S340 Phosphorylation HPRD 19651622, 20166139, 20058876, ...18212344, 20068231
S343 Phosphorylation HPRD 20068231
S344 Phosphorylation HPRD 18669648
T345 Phosphorylation HPRD 18669648, 20068231
S350 Phosphorylation HPRD 18669648, 18212344, 20068231
S488 Phosphorylation Q04759 (PRKCQ) HPRD 12504004


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation Q14247 (CTTN) S298 O43516 (WIPF1) inhibited_association eFIP 31727638


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
R33 I33 Biomuta DOID:363 / uterine cancer [ icgc ]
S145 G145 Biomuta DOID:10534 / stomach cancer [ cosmic ]
S154 F154 Biomuta DOID:4159 / skin cancer [ cosmic ]
S203 F203 Biomuta DOID:5041 / esophageal cancer [ cosmic, icgc ]
R211 M211 Biomuta DOID:10534 / stomach cancer [ cosmic ]
S214 N214 Biomuta DOID:3277 / thymus cancer [ cosmic ]
T218 S218 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
R226 S226 Biomuta DOID:1324 / lung cancer [ cosmic ]
R226 H226 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
R226 C226 Biomuta DOID:4159 / skin cancer [ cosmic ] DOID:9256 / colorectal cancer [ cosmic ] DOID:10534 / stomach cancer [ cosmic ]
R236 H236 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
S244 L244 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
S276 F276 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S343 L343 Biomuta DOID:363 / uterine cancer [ icgc ] DOID:4159 / skin cancer [ cosmic, icgc ] DOID:9256 / colorectal cancer [ cosmic, icgc ]
S344 P344 Biomuta DOID:8618 / oral cavity cancer [ cosmic ]
S344 F344 Biomuta DOID:5041 / esophageal cancer [ cosmic ]
T345 K345 Biomuta DOID:3571 / liver cancer [ cosmic ]
S350 L350 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
T398 I398 Biomuta DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ]
R422 K422 Biomuta DOID:4159 / skin cancer [ cosmic ]
R422 W422 Biomuta DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ]
Y455 * Biomuta DOID:3571 / liver cancer [ cosmic ]
Y468 F468 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
Y468 H468 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]