iPTMnet Report O43493 TGOLN2

Protein Information

UniProt AC / UniProt ID	O43493 / TGON2_HUMAN
Protein Name	Trans-Golgi network integral membrane protein 2 precursor
Gene Name	Name: TGOLN2 Synonyms:TGN46,TGN51;
Organism	Homo sapiens (Human)

PRO ID	PR:O43493 DAG View
PRO Name	trans-Golgi network integral membrane protein 2 (human)
Definition	A trans-Golgi network integral membrane protein 2 that is encoded in the genome of human.
Short Label	hTGOLN2
Category	organism-gene

Interactive Sequence View

	Select/align proteoforms across species

O43493 (TGOLN2) as Substrate

Expanded View

Site	PTM Type	Score	Source	PMID
T23	O-Glycosylation	score1	GlyGen	30459171
S36	O-Glycosylation	score2	GlyGen PhosphoSitePlus	23584533, 30459171, 25813380
N39	N-Glycosylation	score1	GlyGen	32125861, 24190977
S41	O-Glycosylation	score2	GlyGen PhosphoSitePlus	23584533, 25813380
T42	O-Glycosylation	score2	GlyGen PhosphoSitePlus	23584533, 30459171, 25813380
S45	O-Glycosylation	score1	PhosphoSitePlus
S47	O-Glycosylation	score2	GlyGen PhosphoSitePlus	23584533, 25813380
S53	O-Glycosylation	score2	GlyGen PhosphoSitePlus	23584533, 25813380
T54	O-Glycosylation	score2	GlyGen PhosphoSitePlus	23584533, 25813380
S56	O-Glycosylation	score2	GlyGen PhosphoSitePlus	23584533
T62	O-Glycosylation	score2	GlyGen PhosphoSitePlus	23584533, 25813380
S66	O-Glycosylation	score1	GlyGen	25813380
S66	Phosphorylation	score1	PhosphoSitePlus
S68	O-Glycosylation	score1	GlyGen	25813380
S68	Phosphorylation	score1	PhosphoSitePlus
S70	Phosphorylation	score2	phospho.ELM PhosphoSitePlus	18669648
S71	Phosphorylation	score2	phospho.ELM PhosphoSitePlus UniProt	21406692, 23186163, 18669648, ...24275569, 26091039
T76	O-Glycosylation	score1	GlyGen	25813380
T76	Phosphorylation	score1	PhosphoSitePlus
T80	Phosphorylation	score1	PhosphoSitePlus
S84	Phosphorylation	score1	PhosphoSitePlus
S94	Phosphorylation	score2	phospho.ELM PhosphoSitePlus	17287340
S95	Phosphorylation	score1	PhosphoSitePlus
S98	Phosphorylation	score2	phospho.ELM PhosphoSitePlus	17287340
S114	Phosphorylation	score1	PhosphoSitePlus
T118	O-Glycosylation	score2	GlyGen PhosphoSitePlus	23584533, 25813380
T119	O-Glycosylation	score2	GlyGen PhosphoSitePlus	23584533, 25813380
S122	O-Glycosylation	score2	GlyGen PhosphoSitePlus	23584533
T123	O-Glycosylation	score2	GlyGen PhosphoSitePlus	23584533, 25813380
S124	O-Glycosylation	score2	GlyGen PhosphoSitePlus	23584533, 25813380
S126	O-Glycosylation	score2	GlyGen PhosphoSitePlus	23584533, 25813380, 34846842
T132	O-Glycosylation	score2	GlyGen PhosphoSitePlus	23584533, 25813380
T132	Phosphorylation	score1	PhosphoSitePlus
S136	O-Glycosylation	score2	GlyGen PhosphoSitePlus	23584533
T137	O-Glycosylation	score2	GlyGen PhosphoSitePlus	23584533, 25813380
T146	O-Glycosylation	score1	GlyGen	25813380
S150	Phosphorylation	score1	PhosphoSitePlus
N152	N-Glycosylation	score1	GlyGen	24190977
T202	O-Glycosylation	score1	PhosphoSitePlus
S221	Phosphorylation	score2	PhosphoSitePlus UniProt	26091039
S224	Phosphorylation	score1	PhosphoSitePlus
S236	O-Glycosylation	score2	GlyGen PhosphoSitePlus	23584533, 30459171, 25813380
S245	O-Glycosylation	score2	GlyGen PhosphoSitePlus	23584533
S245	Phosphorylation	score1	PhosphoSitePlus
S263	O-Glycosylation	score2	GlyGen PhosphoSitePlus	23584533, 25813380
S263	Phosphorylation	score1	PhosphoSitePlus
S267	O-Glycosylation	score2	GlyGen PhosphoSitePlus	23584533, 25813380
S270	O-Glycosylation	score2	GlyGen PhosphoSitePlus	23584533, 25813380
S290	O-Glycosylation	score2	GlyGen PhosphoSitePlus	23584533, 25813380
S290	Phosphorylation	score1	PhosphoSitePlus
T296	Phosphorylation	score1	PhosphoSitePlus
S298	Phosphorylation	score2	PhosphoSitePlus UniProt	26091039, 23186163
T302	Phosphorylation	score2	PhosphoSitePlus UniProt	26091039
S306	Phosphorylation	score1	PhosphoSitePlus
T318	O-Glycosylation	score2	GlyGen PhosphoSitePlus	23584533
T331	Phosphorylation	score1	PhosphoSitePlus
S347	Phosphorylation	score1	PhosphoSitePlus
S349	Phosphorylation	score1	PhosphoSitePlus
S351	Phosphorylation	score2	PhosphoSitePlus UniProt	26091039, 24275569
S360	Phosphorylation	score1	PhosphoSitePlus
S365	Phosphorylation	score1	PhosphoSitePlus
K426	Ubiquitination	score1	PhosphoSitePlus
S428	Phosphorylation	score1	PhosphoSitePlus
Y430	Phosphorylation	score1	PhosphoSitePlus

Site	PTM Type	Score	Source	PMID
S66	Phosphorylation	score0	HPRD	19664995
S68	Phosphorylation	score0	HPRD	18578522, 19664995
S70	Phosphorylation	score0	HPRD	18669648, 19664995, 20068231
S71	Phosphorylation	score0	HPRD	18578522, 18702456, 19664995, ...18669648, 20166139, 20068231
S94	Phosphorylation	score0	HPRD	17287340
S98	Phosphorylation	score0	HPRD	17287340
T132	Phosphorylation	score0	HPRD	20068231
S224	Phosphorylation	score0	HPRD	20166139
T296	Phosphorylation	score0	HPRD	18452278
S298	Phosphorylation	score0	HPRD	18578522, 20068231, 18452278
S306	Phosphorylation	score0	HPRD	17081983

	Site	PTM Type	PTM Enzyme	Score	Source	PMID
	S428	Phosphorylation		score1	PhosphoSitePlus
	Y430	Phosphorylation		score1	PhosphoSitePlus

PTM sites affected in variants

Site	Variant	Source	Disease [Sample source]
S53	A53	Biomuta	DOID:4606 / bile duct cancer [ cosmic ]
S68	N68	Biomuta	DOID:363 / uterine cancer [ cosmic, icgc ]
S70	W70	Biomuta	DOID:5041 / esophageal cancer [ cosmic, icgc ]
S71	C71	Biomuta	DOID:9256 / colorectal cancer [ cosmic, icgc ]
T80	S80	Biomuta	[ cosmic ] DOID:9253 / gastrointestinal stromal tumor [ cosmic ] DOID:3571 / liver cancer [ cosmic ]
S84	L84	Biomuta	DOID:4159 / skin cancer [ cosmic, icgc ]
S95	C95	Biomuta	DOID:5041 / esophageal cancer [ cosmic ]
T123	S123	Biomuta	DOID:3571 / liver cancer [ cosmic, icgc ]
T132	P132	Biomuta	DOID:2531 / hematologic cancer [ cosmic ]
T137	I137	Biomuta	DOID:1324 / lung cancer [ cosmic, icgc ]
S150	T150	Biomuta	DOID:9253 / gastrointestinal stromal tumor [ cosmic ]
T202	N202	Biomuta	DOID:2531 / hematologic cancer [ cosmic ]
S306	Y306	Biomuta	DOID:363 / uterine cancer [ icgc ]
T331	R331	Biomuta	DOID:1319 / brain cancer [ cosmic ]
S347	F347	Biomuta	DOID:11054 / urinary bladder cancer [ cosmic ]
S360	L360	Biomuta	DOID:11054 / urinary bladder cancer [ cosmic ]

PTM Type		Select All, None
Acetylation	N-Glycosylation	O-Glycosylation
C-Glycosylation	S-Glycosylation	Methylation
Myristoylation	Phosphorylation	Sumoylation
Ubiquitination	S-Nitrosylation

Select organisms		Select All, None
Human	Mouse	Rat
Cow	Chicken	Zebrafish
Fruit fly	C. elegans	Baker's yeast
Fission yeast	A. thaliana	Maize
M. truncatula	Rice (japonica)	Rice (indica)

Or input other organisms

iPTMnet Report for O43493 (TGOLN2)

Protein Information

Interactive Sequence View

O43493 (TGOLN2) as Substrate

PTM sites affected in variants