iPTMnet Report for O43491 (EPB41L2)


Protein Information

Cytoscape View


UniProt AC / UniProt ID O43491 / E41L2_HUMAN
Protein Name Band 4.1-like protein 2
Gene Name Name: EPB41L2
Organism Homo sapiens (Human)

PRO ID PR:O43491
DAG View
PRO Name band 4.1-like protein 2 (human)
Definition A band 4.1-like protein 2 that is encoded in the genome of human.
Short Label hEPB41L2
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


O43491 (EPB41L2) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
T2 Acetylation UniProt 19413330, 22223895
T2 Phosphorylation PhosphoSitePlus
S7 Phosphorylation PhosphoSitePlus   UniProt 23186163
K12 Ubiquitination PhosphoSitePlus
K13 Ubiquitination PhosphoSitePlus
S15 Phosphorylation PhosphoSitePlus
S16 Phosphorylation PhosphoSitePlus
T20 Phosphorylation PhosphoSitePlus
T23 O-Glycosylation GlyGen 23301498, 33214551, 28510447, ...35138101, 30379171, 34725712, 34019948, 29351928, 35132862, 30620550, 32119511, 35254053, 28657654
T23 Phosphorylation PhosphoSitePlus
K24 Ubiquitination PhosphoSitePlus
K28 Ubiquitination PhosphoSitePlus
S38 Phosphorylation PhosphoSitePlus
S39 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 23186163, 21406692, 15302935
K45 Ubiquitination PhosphoSitePlus
S47 Phosphorylation phospho.ELM   PhosphoSitePlus 17525332
S55 Phosphorylation phospho.ELM   PhosphoSitePlus 18220336
S57 Phosphorylation phospho.ELM   PhosphoSitePlus 18220336
S58 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 17287340, 23186163, 24275569, ...18220336
R72 Methylation PhosphoSitePlus
K83 Methylation PhosphoSitePlus
K83 Ubiquitination PhosphoSitePlus
K84 Ubiquitination PhosphoSitePlus
K86 Ubiquitination PhosphoSitePlus
S87 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 23186163, 21406692, 17287340, ...20068231
Y88 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
T89 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 21406692, 16964243, 20068231
K94 Acetylation PhosphoSitePlus
K99 Acetylation PhosphoSitePlus
K99 Ubiquitination PhosphoSitePlus
K100 Ubiquitination PhosphoSitePlus
T103 Phosphorylation PhosphoSitePlus
K114 Ubiquitination PhosphoSitePlus
K126 Ubiquitination PhosphoSitePlus
K135 Ubiquitination PhosphoSitePlus
K140 Ubiquitination PhosphoSitePlus
K144 Ubiquitination PhosphoSitePlus
S151 Phosphorylation PhosphoSitePlus
S157 Phosphorylation PhosphoSitePlus
S159 Phosphorylation PhosphoSitePlus
K160 Ubiquitination PhosphoSitePlus
S170 Phosphorylation PhosphoSitePlus   UniProt 23186163
K171 Acetylation PhosphoSitePlus
K171 Ubiquitination PhosphoSitePlus
K176 Acetylation PhosphoSitePlus
K178 Ubiquitination PhosphoSitePlus
T180 Phosphorylation PhosphoSitePlus
K184 Acetylation PhosphoSitePlus
K184 Ubiquitination PhosphoSitePlus
K191 Acetylation PhosphoSitePlus
T194 Phosphorylation PhosphoSitePlus
K195 Ubiquitination PhosphoSitePlus
T199 Phosphorylation PhosphoSitePlus
K203 Ubiquitination PhosphoSitePlus
K206 Ubiquitination PhosphoSitePlus
S208 Phosphorylation PhosphoSitePlus
C220 Methylation IEDB 31844290
K221 Ubiquitination PhosphoSitePlus
K239 Ubiquitination PhosphoSitePlus
K246 Ubiquitination PhosphoSitePlus
C248 Methylation IEDB 31844290
S266 Phosphorylation PhosphoSitePlus
K270 Ubiquitination PhosphoSitePlus
C328 Methylation IEDB 31844290
K369 Ubiquitination PhosphoSitePlus
K374 Ubiquitination PhosphoSitePlus
K380 Ubiquitination PhosphoSitePlus
S386 Phosphorylation PhosphoSitePlus   UniProt 23186163, 19690332
K399 Ubiquitination PhosphoSitePlus
S402 Phosphorylation PhosphoSitePlus
K444 Ubiquitination PhosphoSitePlus
K474 Ubiquitination PhosphoSitePlus
C488 Methylation IEDB 31844290
S499 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 23186163, 15302935, 20068231
K505 Ubiquitination PhosphoSitePlus
K507 Ubiquitination PhosphoSitePlus
T510 Phosphorylation PhosphoSitePlus
S513 Phosphorylation PhosphoSitePlus
K514 Acetylation PhosphoSitePlus
K514 Ubiquitination PhosphoSitePlus
Y517 Phosphorylation PhosphoSitePlus
S518 Phosphorylation PhosphoSitePlus
S529 Phosphorylation PhosphoSitePlus
R534 Methylation PhosphoSitePlus
S544 Phosphorylation IEDB 30784271
S548 Phosphorylation PhosphoSitePlus
S550 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 23186163, 15302935, 18669648, ...24275569, 20068231
S562 Phosphorylation PhosphoSitePlus   UniProt 23186163
S575 Phosphorylation PhosphoSitePlus
Y577 Phosphorylation PhosphoSitePlus
S598 Phosphorylation PhosphoSitePlus   UniProt 23186163
T600 Phosphorylation PhosphoSitePlus
K601 Ubiquitination PhosphoSitePlus
K611 Ubiquitination PhosphoSitePlus
S614 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 17081983, ...18220336
Y623 Phosphorylation phospho.ELM   PhosphoSitePlus 18083107
S627 Phosphorylation PhosphoSitePlus
K643 Methylation PhosphoSitePlus
K643 Ubiquitination PhosphoSitePlus
S647 Phosphorylation PhosphoSitePlus   UniProt 23186163
S649 Phosphorylation PhosphoSitePlus
K652 Methylation PhosphoSitePlus
K652 Ubiquitination PhosphoSitePlus
S658 Phosphorylation PhosphoSitePlus
T659 Phosphorylation PhosphoSitePlus
K669 Acetylation PhosphoSitePlus
T673 Phosphorylation PhosphoSitePlus
S676 Phosphorylation PhosphoSitePlus
T679 Phosphorylation PhosphoSitePlus
S682 Phosphorylation PhosphoSitePlus
S683 Phosphorylation PhosphoSitePlus
T686 Phosphorylation PhosphoSitePlus
K693 Ubiquitination PhosphoSitePlus
K694 Acetylation PhosphoSitePlus
T706 Phosphorylation PhosphoSitePlus
K712 Ubiquitination PhosphoSitePlus
S715 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 21406692, 23186163, 18669648, ...24275569, 20068231
S718 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 20068231
S734 Phosphorylation PhosphoSitePlus
S742 Phosphorylation PhosphoSitePlus
S743 Phosphorylation PhosphoSitePlus
S744 Phosphorylation PhosphoSitePlus
S748 Phosphorylation PhosphoSitePlus
Y756 Phosphorylation PhosphoSitePlus
T763 Phosphorylation PhosphoSitePlus
T766 Phosphorylation PhosphoSitePlus
R768 Methylation PhosphoSitePlus
Y773 Phosphorylation phospho.ELM   PhosphoSitePlus 17287340
S798 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
T801 Phosphorylation PhosphoSitePlus
S806 Phosphorylation phospho.ELM 18669648
K827 Ubiquitination PhosphoSitePlus
S828 Phosphorylation PhosphoSitePlus   UniProt 23186163
T875 Phosphorylation PhosphoSitePlus
S881 Phosphorylation PhosphoSitePlus
S884 Phosphorylation PhosphoSitePlus
K892 Ubiquitination PhosphoSitePlus
T899 O-Glycosylation GlyGen 23301498, 33214551, 28510447, ...35138101, 30379171, 34725712, 34019948, 29351928, 35132862, 30620550, 32119511, 35254053, 28657654
T905 Phosphorylation PhosphoSitePlus
Y906 Phosphorylation PhosphoSitePlus
S908 O-Glycosylation GlyGen 23301498, 33214551, 32938750, ...35138101, 30379171, 34725712, 28510447, 34019948, 35254053, 35132862, 30620550, 32119511, 29351928, 28657654
S908 Phosphorylation PhosphoSitePlus
S919 O-Glycosylation GlyGen 34846842
T921 O-Glycosylation GlyGen 23301498, 33214551, 28510447, ...35138101, 30379171, 34725712, 34019948, 29351928, 35132862, 30620550, 32119511, 35254053, 28657654
T927 O-Glycosylation GlyGen 23301498, 33214551, 28510447, ...35138101, 30379171, 34725712, 34019948, 29351928, 35132862, 30620550, 32119511, 35254053, 28657654
S930 O-Glycosylation GlyGen 23301498, 33214551, 28510447, ...35138101, 30379171, 34725712, 34019948, 29351928, 35132862, 30620550, 32119511, 35254053, 28657654
T944 Phosphorylation PhosphoSitePlus
K946 Ubiquitination PhosphoSitePlus
S950 Phosphorylation PhosphoSitePlus
S987 Phosphorylation PhosphoSitePlus
K995 Ubiquitination PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S38 Phosphorylation HPRD 19651622
S39 Phosphorylation HPRD 19413330, 19651622, 15302935, ...20068231, 18452278
S47 Phosphorylation HPRD 17525332, 18077418
S58 Phosphorylation HPRD 19413330, 18578522, 17287340, ...19664995, 20068231
S87 Phosphorylation HPRD 18578522, 17287340, 18212344, ...19651622, 20166139, 20068231
Y88 Phosphorylation HPRD 19413330, 18578522, 18669648, ...18212344
T89 Phosphorylation HPRD 19651622, 16964243, 20068231
Y297 Phosphorylation HPRD 20068231
S302 Phosphorylation HPRD 20068231
T305 Phosphorylation HPRD 20068231
S449 Phosphorylation HPRD 20068231
S499 Phosphorylation HPRD 15302935, 20068231
T510 Phosphorylation HPRD 18212344
S518 Phosphorylation HPRD 20068231
S529 Phosphorylation HPRD 20068231
S550 Phosphorylation HPRD 18669648, 15302935, 20068231
S598 Phosphorylation HPRD 20068231
S614 Phosphorylation HPRD 18669648, 20068231
Y623 Phosphorylation HPRD 18083107, 18707149
S647 Phosphorylation HPRD 20068231
S682 Phosphorylation HPRD 19651622, 20068231
S683 Phosphorylation HPRD 19651622, 20068231
S715 Phosphorylation HPRD 18669648, 19664994, 19691289, ...20068231, 18452278
S718 Phosphorylation HPRD 19664994, 18669648, 20058876, ...20068231, 18452278
Y773 Phosphorylation HPRD 17287340
S798 Phosphorylation HPRD 18669648, 20068231
S806 Phosphorylation HPRD 18669648
Site PTM Type PTM Enzyme Score Source PMID
K611 Ubiquitination PhosphoSitePlus
S613 Phosphorylation PhosphoSitePlus
Y703 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S15 C15 Biomuta DOID:1324 / lung cancer [ cosmic ]
S39 F39 Biomuta DOID:4159 / skin cancer [ cosmic ]
S47 F47 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S47 A47 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S55 I55 Biomuta DOID:363 / uterine cancer [ icgc ]
R72 S72 Biomuta DOID:8618 / oral cavity cancer [ cosmic ] DOID:11934 / head and neck cancer [ icgc ]
S87 L87 Biomuta DOID:11054 / urinary bladder cancer [ cosmic ]
K114 Q114 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
S151 N151 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ] DOID:9256 / colorectal cancer [ cosmic ]
S151 T151 Biomuta DOID:1319 / brain cancer [ cosmic, icgc ]
S157 * Biomuta DOID:11054 / urinary bladder cancer [ cosmic ]
K178 N178 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
K195 N195 Biomuta DOID:363 / uterine cancer [ icgc ]
T199 I199 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
K206 N206 Biomuta DOID:10534 / stomach cancer [ cosmic ]
C248 Y248 Biomuta DOID:1324 / lung cancer [ cosmic ] DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ]
S386 L386 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S449 F449 Biomuta DOID:4159 / skin cancer [ cosmic ]
S449 A449 Biomuta DOID:3571 / liver cancer [ cosmic, icgc ]
C488 F488 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
S499 F499 Biomuta DOID:10534 / stomach cancer [ cosmic ]
S529 T529 Biomuta DOID:1319 / brain cancer [ cosmic, icgc ]
S548 F548 Biomuta DOID:10534 / stomach cancer [ cosmic ]
S550 N550 Biomuta DOID:1319 / brain cancer [ cosmic, icgc ]
S575 L575 Biomuta DOID:4159 / skin cancer [ cosmic ]
S613 L613 Biomuta DOID:4159 / skin cancer [ cosmic ]
S614 F614 Biomuta DOID:4159 / skin cancer [ cosmic ]
S676 F676 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
T679 K679 Biomuta DOID:3571 / liver cancer [ cosmic ]
S683 L683 Biomuta DOID:4159 / skin cancer [ cosmic ]
K693 M693 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
K693 N693 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ] DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
Y703 C703 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S715 L715 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ] DOID:1324 / lung cancer [ cosmic, icgc ]
S718 H718 Biomuta DOID:10534 / stomach cancer [ cosmic ]
S748 N748 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
T766 I766 Biomuta DOID:4159 / skin cancer [ cosmic ]
Y773 C773 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S798 I798 Biomuta DOID:4362 / cervical cancer [ cosmic, icgc ]
Y906 C906 Biomuta DOID:8618 / oral cavity cancer [ cosmic ] DOID:1324 / lung cancer [ cosmic ]
S908 C908 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
T921 M921 Biomuta DOID:10534 / stomach cancer [ cosmic ]
S930 F930 Biomuta DOID:4159 / skin cancer [ cosmic ]
S987 L987 Biomuta DOID:3571 / liver cancer [ cosmic ]