Protein Information

Cytoscape View


UniProt AC / UniProt ID O43488 / ARK72_HUMAN
Protein Name Aflatoxin B1 aldehyde reductase member 2
Gene Name Name: AKR7A2
Synonyms:AFAR,AFAR1,AKR7;
Organism Homo sapiens (Human)

PRO ID PR:O43488
DAG View
PRO Name aflatoxin B1 aldehyde reductase member 2 (human)
Definition An aflatoxin B1 aldehyde reductase member 2 that is encoded in the genome of human.
Short Label hAKR7A2
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


O43488 (AKR7A2) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S20 Phosphorylation PhosphoSitePlus
S40 Phosphorylation PhosphoSitePlus
S56 Phosphorylation PhosphoSitePlus
R61 Methylation PhosphoSitePlus
S78 Phosphorylation PhosphoSitePlus
K105 Ubiquitination PhosphoSitePlus
K112 Ubiquitination PhosphoSitePlus
K115 Ubiquitination PhosphoSitePlus
S118 Phosphorylation PhosphoSitePlus
K128 Acetylation PhosphoSitePlus
K128 Ubiquitination PhosphoSitePlus
Y223 Phosphorylation PhosphoSitePlus
Y225 Phosphorylation PhosphoSitePlus
K236 Ubiquitination PhosphoSitePlus
R250 Methylation PhosphoSitePlus
S255 Phosphorylation HPRD   PhosphoSitePlus   UniProt 20166139, 23186163, 20068231, ...24275569
T259 Phosphorylation PhosphoSitePlus
S287 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S40 W40 Biomuta DOID:11054 / urinary bladder cancer [ icgc ]
S78 I78 Biomuta DOID:1324 / lung cancer [ tcga ]
K112 Q112 Biomuta DOID:363 / uterine cancer [ tcga ]
S118 N118 Biomuta DOID:1324 / lung cancer [ tcga ]
Y225 * Biomuta DOID:3571 / liver cancer [ icgc ]
Y225 C225 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc, tcga ]
S255 T255 Biomuta DOID:9256 / colorectal cancer [ icgc ] DOID:1909 / melanoma [ cosmic ]