iPTMnet Report for O43474 (KLF4)
Protein Information
| UniProt AC / UniProt ID | O43474 / KLF4_HUMAN |
| Protein Name | Krueppel-like factor 4 |
| Gene Name | Name: KLF4 Synonyms:EZF,GKLF; |
| Organism | Homo sapiens (Human) |
| PRO ID | PR:O43474 |
| PRO Name | krueppel-like factor 4 (human) |
| Definition | A krueppel-like factor 4 that is encoded in the genome of human. |
| Short Label | hKLF4 |
| Category | organism-gene |
DAG ViewO43474 (KLF4) as Substrate
 |
Site | PTM Type | PTM Enzyme | Score | Source | PMID |
|---|---|---|---|---|---|---|
| K32 | Ubiquitination | score3 | PhosphoSitePlus UniProt | 18655026 | ||
| S132 | Phosphorylation | score0 | RLIMS-P | 29526737 | ||
| K228 | Acetylation | score1 | PhosphoSitePlus | |||
| K232 | Acetylation | score1 | PhosphoSitePlus | |||
| S234 | Phosphorylation | score3 | PhosphoSitePlus RLIMS-P | 31281496 | ||
| S236 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S240 | Phosphorylation | score1 | phospho.ELM | 18220336 | ||
| S244 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S251 | O-Glycosylation | score1 | GlyGen | 33214551, 29237092 | ||
| S254 | Phosphorylation | score2 | PhosphoSitePlus UniProt | 20068231 | ||
| S258 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K278 | Sumoylation | score1 | PhosphoSitePlus | |||
| T316 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S327 | Phosphorylation | score1 | PhosphoSitePlus | |||
| T429 | Phosphorylation | score0 | RLIMS-P | 25116380 | ||
| S444 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S445 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K448 | Sumoylation | score1 | PhosphoSitePlus | |||
| K448 | Ubiquitination | score1 | PhosphoSitePlus | |||
| T453 | Phosphorylation | score1 | PhosphoSitePlus | |||
| T455 | Phosphorylation | score1 | PhosphoSitePlus |
PTM-dependent PPI
|
PTM type | Substrate | Site | Interactant | Association type | Source | PMID |
|---|---|---|---|---|---|---|---|
| Phosphorylation | O43474 (KLF4) | S132 | O14980 (XPO1) | inhibited_association | eFIP | 29526737 | |
| Phosphorylation | P40763 (STAT3) | Y705 | O43474 (KLF4) | unknown | eFIP | 24129709 | |
| Phosphorylation | Q92769 (HDAC2) | S424 | O43474 (KLF4) | inhibited_association | eFIP | 19486889 |
PTM sites affected in variants
| Site | Variant | Source | PMID | Disease [Sample source] |
|---|---|---|---|---|
| S236 | R236 | Biomuta | DOID:2531 / hematologic cancer [ cosmic ] | |
| S244 | N244 | Biomuta | DOID:9253 / gastrointestinal stromal tumor [ cosmic ] | |
| T316 | P316 | Biomuta | DOID:1793 / pancreatic cancer [ cosmic ] |
