iPTMnet Report for O43464 (HTRA2)


Protein Information

Cytoscape View


UniProt AC / UniProt ID O43464 / HTRA2_HUMAN
Protein Name Serine protease HTRA2, mitochondrial precursor
Gene Name Name: HTRA2
Synonyms:OMI,PRSS25;
Organism Homo sapiens (Human)

PRO ID PR:O43464
DAG View
PRO Name serine protease HTRA2, mitochondrial (human)
Definition A serine protease HTRA2, mitochondrial that is encoded in the genome of human.
Short Label hHTRA2
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


O43464 (HTRA2) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
R5 Methylation PhosphoSitePlus
R8 Methylation PhosphoSitePlus
T51 Phosphorylation PhosphoSitePlus
T54 Phosphorylation PhosphoSitePlus
S96 Phosphorylation PhosphoSitePlus
S142 Phosphorylation neXtProt   PhosphoSitePlus   RLIMS-P   Signor 21701498, 17906618
S142 Phosphorylation P53778 (MAPK12) neXtProt   PhosphoSitePlus 17906618
S142 Phosphorylation Q9BXM7 (PINK1) Signor 17906618
T157 Phosphorylation PhosphoSitePlus
S212 Phosphorylation neXtProt   PhosphoSitePlus   RLIMS-P   Signor 17311912, 27825081
S212 Phosphorylation P31749 (AKT1) neXtProt   PhosphoSitePlus   Signor 17311912
S212 Phosphorylation P31751 (AKT2) neXtProt   PhosphoSitePlus   Signor 17311912
K237 Ubiquitination PhosphoSitePlus
T242 Phosphorylation PhosphoSitePlus
T326 Phosphorylation PhosphoSitePlus
S330 Phosphorylation PhosphoSitePlus
S352 Phosphorylation PhosphoSitePlus
K395 Ubiquitination PhosphoSitePlus
S400 Phosphorylation IEDB   neXtProt   PhosphoSitePlus   RLIMS-P   Signor 21701498, 31848261
S400 Phosphorylation Q00535 (CDK5) neXtProt   PhosphoSitePlus   Signor 21701498
T453 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
Y296 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S96 * Biomuta DOID:363 / uterine cancer [ cosmic ]
T453 N453 Biomuta DOID:4606 / bile duct cancer [ cosmic ]