iPTMnet Report for O43463 (SUV39H1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID O43463 / SUV91_HUMAN
Protein Name Histone-lysine N-methyltransferase SUV39H1
Gene Name Name: SUV39H1
Synonyms:KMT1A,SUV39H;
Organism Homo sapiens (Human)

PRO ID PR:O43463
DAG View
PRO Name histone-lysine N-methyltransferase SUV39H1 (human)
Definition A histone-lysine N-methyltransferase SUV39H1 that is encoded in the genome of human.
Short Label hSUV39H1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


O43463 (SUV39H1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K6 Ubiquitination PhosphoSitePlus
K13 Ubiquitination PhosphoSitePlus
S15 Phosphorylation RLIMS-P 23376847
C23 Methylation IEDB 31844290
K37 Ubiquitination PhosphoSitePlus
K63 Ubiquitination PhosphoSitePlus
S70 Phosphorylation PhosphoSitePlus
K81 Ubiquitination PhosphoSitePlus
K87 Ubiquitination PhosphoSitePlus
K91 Ubiquitination PhosphoSitePlus
K105 Methylation PhosphoSitePlus
K121 Ubiquitination PhosphoSitePlus
K123 Methylation PhosphoSitePlus
K138 Ubiquitination PhosphoSitePlus
T146 Phosphorylation PhosphoSitePlus
R214 Methylation PhosphoSitePlus
K266 Acetylation PhosphoSitePlus   UniProt 18004385
S268 Phosphorylation IEDB 30784271
Y297 Phosphorylation PhosphoSitePlus
Y303 Phosphorylation PhosphoSitePlus
Y308 Phosphorylation PhosphoSitePlus
S391 Phosphorylation P24941 (CDK2) phospho.ELM   PhosphoSitePlus   RLIMS-P+   UniProt 21406692, 23186163, 17081983, ...18669648, 24728993, 19690332, 20068231
Site PTM Type PTM Enzyme Score Source PMID
S391 Phosphorylation HPRD 19413330, 17081983, 19664995, ...19651622, 18669648, 20068231, 17924679


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation P04637 (TP53) S392 O43463 (SUV39H1) increased_association eFIP 31617338


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K87 * Biomuta DOID:3571 / liver cancer [ cosmic, icgc, tcga ]
K121 N121 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
R214 Q214 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
Y303 * Biomuta DOID:8618 / oral cavity cancer [ cosmic ] DOID:11934 / head and neck cancer [ icgc ]