iPTMnet Report for O43462 (MBTPS2)


Protein Information

Cytoscape View


UniProt AC / UniProt ID O43462 / MBTP2_HUMAN
Protein Name Membrane-bound transcription factor site-2 protease
Gene Name Name: MBTPS2
Synonyms:S2P;
Organism Homo sapiens (Human)

PRO ID PR:O43462
DAG View
PRO Name membrane-bound transcription factor site-2 protease (human)
Definition A membrane-bound transcription factor site-2 protease that is encoded in the genome of human.
Short Label hMBTPS2
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


O43462 (MBTPS2) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S116 Phosphorylation PhosphoSitePlus
S117 Phosphorylation PhosphoSitePlus
S118 Phosphorylation PhosphoSitePlus
S119 Phosphorylation PhosphoSitePlus
S120 Phosphorylation PhosphoSitePlus
S125 Phosphorylation PhosphoSitePlus
S126 Phosphorylation PhosphoSitePlus
S127 Phosphorylation PhosphoSitePlus
S128 Phosphorylation PhosphoSitePlus
S265 Phosphorylation PhosphoSitePlus
N336 N-Glycosylation GlyGen 24190977
N337 N-Glycosylation GlyGen   UniProt 10419520, 24190977
K363 Ubiquitination PhosphoSitePlus
K379 Ubiquitination PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S126 F126 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S127 P127 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
K379 T379 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]