iPTMnet Report for O43432 (EIF4G3)


Protein Information

Cytoscape View


UniProt AC / UniProt ID O43432 / IF4G3_HUMAN
Protein Name Eukaryotic translation initiation factor 4 gamma 3
Gene Name Name: EIF4G3
Organism Homo sapiens (Human)

PRO ID PR:O43432
DAG View
PRO Name eukaryotic translation initiation factor 4 gamma 3 (human)
Definition A eukaryotic translation initiation factor 4 gamma 3 that is encoded in the genome of human.
Short Label hEIF4G3
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


O43432 (EIF4G3) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
Y119 Phosphorylation PhosphoSitePlus
S164 Phosphorylation PhosphoSitePlus
T168 Phosphorylation PhosphoSitePlus
T211 O-Glycosylation GlyGen 23301498, 33214551, 35138101, ...31637018, 30379171, 22661428, 31492838, 35254053, 34019948, 30620550, 32870666, 32119511, 35289036, 29351928, 28657654
K229 Methylation PhosphoSitePlus
S230 Phosphorylation PhosphoSitePlus   UniProt 21406692, 23186163, 20068231
S232 O-Glycosylation GlyGen 23301498, 33214551, 35138101, ...31637018, 30379171, 22661428, 31492838, 35254053, 34019948, 30620550, 32870666, 32119511, 35289036, 29351928, 28657654
S232 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 21406692, 23186163, 24275569, ...18088087, 20068231
S240 Phosphorylation PhosphoSitePlus
S258 O-Glycosylation GlyGen 23301498, 33214551, 35138101, ...31637018, 30379171, 22661428, 31492838, 35254053, 34019948, 30620550, 32870666, 32119511, 35289036, 29351928, 28657654
S267 Phosphorylation PhosphoSitePlus   UniProt 24275569
T269 Phosphorylation PhosphoSitePlus
S277 O-Glycosylation GlyGen 23301498, 33214551, 35138101, ...31637018, 30379171, 22661428, 31492838, 35254053, 34019948, 30620550, 32870666, 32119511, 35289036, 29351928, 28657654
T278 O-Glycosylation GlyGen 23301498, 33214551, 35138101, ...31637018, 30379171, 22661428, 31492838, 35254053, 34019948, 30620550, 32870666, 32119511, 35289036, 29351928, 28657654
T283 O-Glycosylation GlyGen 23301498, 33214551, 35138101, ...31637018, 30379171, 22661428, 31492838, 35254053, 34019948, 30620550, 32870666, 32119511, 35289036, 29351928, 28657654
S284 O-Glycosylation GlyGen 23301498, 33214551, 35138101, ...31637018, 30379171, 22661428, 31492838, 35254053, 34019948, 30620550, 32870666, 32119511, 35289036, 29351928, 28657654
S285 O-Glycosylation GlyGen 23301498, 33214551, 35138101, ...31637018, 30379171, 22661428, 31492838, 35254053, 34019948, 30620550, 32870666, 32119511, 35289036, 29351928, 28657654
S289 O-Glycosylation GlyGen 23301498, 34846842, 33214551, ...35138101, 31637018, 30379171, 22661428, 31492838, 35254053, 34019948, 30620550, 32870666, 32119511, 35289036, 29351928, 28657654
T294 O-Glycosylation GlyGen 23301498, 33214551, 35138101, ...31637018, 30379171, 22661428, 31492838, 35254053, 34019948, 30620550, 32870666, 32119511, 35289036, 29351928, 28657654
T295 O-Glycosylation GlyGen 22661428
C301 Methylation IEDB 31844290
S371 Phosphorylation PhosphoSitePlus
C461 Methylation IEDB 31844290
S495 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 21406692, 18088087, 16964243, ...18669648, 24275569, 17693683, 23186163, 19690332, 20068231, 17081983
T504 Phosphorylation PhosphoSitePlus
T518 Phosphorylation PhosphoSitePlus
R669 Methylation PhosphoSitePlus
R673 Methylation PhosphoSitePlus
R692 Methylation PhosphoSitePlus
S719 Phosphorylation PhosphoSitePlus
S736 O-Glycosylation GlyGen 23301498, 33214551, 35138101, ...31637018, 30379171, 22661428, 31492838, 35254053, 34019948, 30620550, 32870666, 32119511, 35289036, 29351928, 28657654
S741 Phosphorylation PhosphoSitePlus
K750 Ubiquitination PhosphoSitePlus
S804 Phosphorylation PhosphoSitePlus
K857 Ubiquitination PhosphoSitePlus
S866 Phosphorylation PhosphoSitePlus
S889 Phosphorylation IEDB   PhosphoSitePlus 27920218
K894 Ubiquitination PhosphoSitePlus
K901 Ubiquitination PhosphoSitePlus
C913 Methylation IEDB 31844290
K919 Ubiquitination PhosphoSitePlus
K938 Ubiquitination PhosphoSitePlus
K944 Acetylation PhosphoSitePlus
K944 Ubiquitination PhosphoSitePlus
R948 Methylation PhosphoSitePlus
C982 Methylation IEDB 31844290
K1013 Ubiquitination PhosphoSitePlus
S1050 O-Glycosylation GlyGen 23301498, 33214551, 35138101, ...31637018, 30379171, 22661428, 31492838, 35254053, 34019948, 30620550, 32870666, 32119511, 35289036, 29351928, 28657654
K1069 Ubiquitination PhosphoSitePlus
S1074 Phosphorylation PhosphoSitePlus
K1077 Methylation PhosphoSitePlus
S1110 Phosphorylation PhosphoSitePlus
S1112 Phosphorylation PhosphoSitePlus
T1113 Phosphorylation PhosphoSitePlus
T1116 Phosphorylation PhosphoSitePlus
S1122 Phosphorylation PhosphoSitePlus
S1128 Phosphorylation PhosphoSitePlus
S1131 Phosphorylation PhosphoSitePlus
S1156 Phosphorylation Q14012 (CAMK1) , Q96NX5 (CAMK1G) , Q6P2M8 (PNCK) neXtProt   PhosphoSitePlus   Signor   UniProt 22514323, 14507913
S1157 Phosphorylation PhosphoSitePlus
S1165 Phosphorylation PhosphoSitePlus
S1190 Phosphorylation PhosphoSitePlus
T1191 Phosphorylation PhosphoSitePlus
T1198 Phosphorylation PhosphoSitePlus
S1218 Phosphorylation PhosphoSitePlus   UniProt 23186163
K1240 Acetylation PhosphoSitePlus
K1292 Ubiquitination PhosphoSitePlus
S1343 Phosphorylation PhosphoSitePlus
S1407 Phosphorylation PhosphoSitePlus
S1409 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163
K1419 Ubiquitination PhosphoSitePlus
K1428 Ubiquitination PhosphoSitePlus
K1432 Ubiquitination PhosphoSitePlus
K1506 Ubiquitination PhosphoSitePlus
S1582 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S230 Phosphorylation HPRD 19651622, 17081983, 20068231
S232 Phosphorylation HPRD 19651622, 18088087, 17081983, ...20068231, 19664995
S240 Phosphorylation HPRD 20068231
S495 Phosphorylation HPRD 17322306, 18088087, 18212344, ...18767875, 17693683, 19664994, 18452278, 19651622, 18669648, 18707149, 20166139, 20068231, 16964243
S1156 Phosphorylation Q14012 (CAMK1) HPRD 14507913
S1343 Phosphorylation HPRD 19413330
S1409 Phosphorylation HPRD 17322306, 18767875, 18669648, ...19413330


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S164 I164 Biomuta [ cosmic ]
T168 A168 Biomuta DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ]
T269 A269 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S371 R371 Biomuta DOID:2394 / ovarian cancer [ cosmic, icgc ]
C461 R461 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
R669 Q669 Biomuta DOID:363 / uterine cancer [ icgc ] DOID:9256 / colorectal cancer [ cosmic, icgc ] DOID:10534 / stomach cancer [ cosmic, icgc ] DOID:5158 / pleural cancer [ cosmic ] DOID:1324 / lung cancer [ cosmic ]
R673 L673 Biomuta DOID:1319 / brain cancer [ cosmic, icgc ]
R673 * Biomuta DOID:2394 / ovarian cancer [ cosmic ]
S741 G741 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
S741 R741 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
R948 H948 Biomuta DOID:10283 / prostate cancer [ cosmic, icgc ] DOID:10534 / stomach cancer [ cosmic ]
R948 C948 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S1110 L1110 Biomuta DOID:1612 / breast cancer [ icgc ]
T1113 M1113 Biomuta DOID:3571 / liver cancer [ cosmic, icgc ]
T1116 M1116 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S1122 F1122 Biomuta DOID:4159 / skin cancer [ cosmic ]
K1240 N1240 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S1409 R1409 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
K1428 N1428 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]