Protein Information

Cytoscape View


UniProt AC / UniProt ID O43422 / P52K_HUMAN
Protein Name 52 kDa repressor of the inhibitor of the protein kinase
Gene Name Name: THAP12
Synonyms:DAP4,P52RIPK,PRKRIR,THAP0;
Organism Homo sapiens (Human)

PRO ID PR:O43422
DAG View
PRO Name 52 kDa repressor of the inhibitor of the protein kinase (human)
Definition A 52 kDa repressor of the inhibitor of the protein kinase that is encoded in the genome of human.
Short Label hTHAP12
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


O43422 (THAP12) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
T47 Phosphorylation PhosphoSitePlus
T64 Phosphorylation PhosphoSitePlus
S97 Phosphorylation PhosphoSitePlus
S107 Phosphorylation PhosphoSitePlus
S141 Phosphorylation PhosphoSitePlus
K160 Ubiquitination PhosphoSitePlus
Y330 Phosphorylation PhosphoSitePlus
S345 Phosphorylation PhosphoSitePlus
S513 Phosphorylation PhosphoSitePlus
T515 Phosphorylation PhosphoSitePlus
S566 Phosphorylation PhosphoSitePlus   UniProt 23186163
S579 Phosphorylation PhosphoSitePlus
S595 Phosphorylation PhosphoSitePlus
K603 Ubiquitination PhosphoSitePlus
S606 Phosphorylation PhosphoSitePlus
S610 Phosphorylation PhosphoSitePlus
K654 Acetylation PhosphoSitePlus
K654 Ubiquitination PhosphoSitePlus
K705 Ubiquitination PhosphoSitePlus
K747 Ubiquitination PhosphoSitePlus
S755 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S97 R97 Biomuta DOID:3070 / malignant glioma [ tcga ] DOID:2531 / hematologic cancer [ tcga ]
S566 F566 Biomuta DOID:1324 / lung cancer [ tcga ]
S595 L595 Biomuta DOID:3571 / liver cancer [ icgc ] DOID:0070003 / blastoma [ cosmic ]