iPTMnet Report for O43402 (EMC8)


Protein Information

Cytoscape View


UniProt AC / UniProt ID O43402 / EMC8_HUMAN
Protein Name ER membrane protein complex subunit 8
Gene Name Name: EMC8
Synonyms:C16orf2,C16orf4,COX4AL,COX4NB,FAM158B,NOC4;
Organism Homo sapiens (Human)

PRO ID PR:O43402
DAG View
PRO Name ER membrane protein complex subunit 8 (human)
Definition An ER membrane protein complex subunit 8 that is encoded in the genome of human.
Short Label hEMC8
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


O43402 (EMC8) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K5 Ubiquitination PhosphoSitePlus
K13 Ubiquitination PhosphoSitePlus
K20 Ubiquitination PhosphoSitePlus
K34 Ubiquitination PhosphoSitePlus
K100 Ubiquitination PhosphoSitePlus
S103 Phosphorylation PhosphoSitePlus
K110 Ubiquitination PhosphoSitePlus
C136 Methylation IEDB 31844290
S173 O-Glycosylation GlyGen 29351928
S173 Phosphorylation PhosphoSitePlus
S177 O-Glycosylation GlyGen 29351928
S177 Phosphorylation PhosphoSitePlus
R194 Methylation PhosphoSitePlus
K204 Ubiquitination PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K100 N100 Biomuta DOID:9256 / colorectal cancer [ icgc ]
S103 N103 Biomuta DOID:4606 / bile duct cancer [ cosmic ]
S173 L173 Biomuta DOID:8618 / oral cavity cancer [ cosmic ] DOID:11934 / head and neck cancer [ icgc ]
S177 C177 Biomuta DOID:1324 / lung cancer [ cosmic ]
R194 Q194 Biomuta DOID:9256 / colorectal cancer [ cosmic ] DOID:263 / kidney cancer [ cosmic ]
R194 W194 Biomuta DOID:4159 / skin cancer [ cosmic ] DOID:9256 / colorectal cancer [ cosmic ]