Protein Information

Cytoscape View


UniProt AC / UniProt ID O43395 / PRPF3_HUMAN
Protein Name U4/U6 small nuclear ribonucleoprotein Prp3
Gene Name Name: PRPF3
Synonyms:HPRP3;
Organism Homo sapiens (Human)

PRO ID PR:O43395
DAG View
PRO Name U4/U6 small nuclear ribonucleoprotein Prp3 (human)
Definition A U4/U6 small nuclear ribonucleoprotein Prp3 that is encoded in the genome of human.
Short Label hPRPF3
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


O43395 (PRPF3) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K17 Ubiquitination PhosphoSitePlus
C37 S-Nitrosylation dbSNO 19483679
K52 Ubiquitination PhosphoSitePlus
R61 Methylation PhosphoSitePlus
K65 Ubiquitination PhosphoSitePlus
S102 Phosphorylation PhosphoSitePlus
S106 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S131 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S133 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648, 16565220
T138 Phosphorylation PhosphoSitePlus
K143 Ubiquitination PhosphoSitePlus
K158 Ubiquitination PhosphoSitePlus
S161 Phosphorylation O14757 (CHEK1) PhosphoSitePlus 21851590
S164 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 20068231
T167 Phosphorylation P24941 (CDK2) phospho.ELM   PhosphoSitePlus   UniProt 18669648, 18847512, 20068231
T172 O-Glycosylation GlyGen 28510447, 29351928
T172 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S175 O-Glycosylation GlyGen 28510447, 29351928
S175 Phosphorylation PhosphoSitePlus
S176 O-Glycosylation GlyGen 28510447, 29351928
S176 Phosphorylation PhosphoSitePlus
T186 Phosphorylation PhosphoSitePlus
K252 Sumoylation PhosphoSitePlus
K252 Ubiquitination PhosphoSitePlus
K270 Ubiquitination PhosphoSitePlus
T280 Phosphorylation PhosphoSitePlus
K289 Sumoylation PhosphoSitePlus
K294 Methylation PhosphoSitePlus
K334 Acetylation PhosphoSitePlus
K350 Ubiquitination PhosphoSitePlus
S356 Phosphorylation phospho.ELM   PhosphoSitePlus 17525332
K361 Methylation PhosphoSitePlus
K376 Sumoylation PhosphoSitePlus
Y411 Phosphorylation PhosphoSitePlus
T415 Phosphorylation PhosphoSitePlus
T432 Phosphorylation PhosphoSitePlus
S479 Phosphorylation PhosphoSitePlus
T494 Phosphorylation P68400 (CSNK2A1) PhosphoSitePlus   RLIMS-P   Signor 17932117
K519 Acetylation PhosphoSitePlus
K559 Sumoylation PhosphoSitePlus
T611 Phosphorylation PhosphoSitePlus
S619 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 21406692, 23186163, 17081983, ...18318008, 18669648, 24275569, 17287340, 19690332, 20068231
Site PTM Type PTM Enzyme Score Source PMID
S105 Phosphorylation HPRD 20068231
S106 Phosphorylation HPRD 18669648
S131 Phosphorylation HPRD 18669648, 20068231
S133 Phosphorylation HPRD 18669648, 19007248, 20068231, ...16565220
S161 Phosphorylation HPRD 20068231
S164 Phosphorylation HPRD 19413330, 18669648, 20068231
T167 Phosphorylation HPRD 19413330, 18669648, 20068231
T172 Phosphorylation HPRD 18669648, 20068231
S175 Phosphorylation HPRD 20068231
S176 Phosphorylation HPRD 20068231
T264 Phosphorylation HPRD 20068231
S356 Phosphorylation HPRD 17525332
Y411 Phosphorylation HPRD 18452278
T415 Phosphorylation HPRD 18452278
T611 Phosphorylation HPRD 20068231
S619 Phosphorylation HPRD 17322306, 17287340, 19007248, ...18452278, 19651622, 18669648, 20068231


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
R61 Q61 Biomuta DOID:3571 / liver cancer [ icgc ] DOID:0070003 / blastoma [ cosmic ]
S106 * Biomuta DOID:2994 / germ cell cancer [ cosmic ]
S131 L131 Biomuta DOID:1324 / lung cancer [ tcga ]
T138 I138 Biomuta DOID:11054 / urinary bladder cancer [ tcga ]
K270 T270 Biomuta DOID:1793 / pancreatic cancer [ icgc ] DOID:0070003 / blastoma [ cosmic ]
K334 N334 Biomuta DOID:363 / uterine cancer [ cosmic, icgc, tcga ]
S356 * Biomuta DOID:363 / uterine cancer [ tcga ]
Y411 H411 Biomuta DOID:263 / kidney cancer [ cosmic, tcga ]
S479 Y479 Biomuta DOID:9256 / colorectal cancer [ icgc, tcga ] DOID:1909 / melanoma [ cosmic ]