iPTMnet Report for O43353 (RIPK2)
Protein Information
| UniProt AC / UniProt ID | O43353 / RIPK2_HUMAN |
| Protein Name | Receptor-interacting serine/threonine-protein kinase 2 |
| Gene Name | Name: RIPK2 Synonyms:CARDIAK;ORFNames:UNQ277/PRO314/PRO34092; |
| Organism | Homo sapiens (Human) |
| PRO ID | PR:O43353 |
| PRO Name | receptor-interacting serine/threonine-protein kinase 2 (human) |
| Definition | A receptor-interacting serine/threonine-protein kinase 2 that is encoded in the genome of human. |
| Short Label | hRIPK2 |
| Category | organism-gene |
DAG ViewO43353 (RIPK2) as Substrate
 |
Site | PTM Type | PTM Enzyme | Score | Source | PMID |
|---|---|---|---|---|---|---|
| K17 | Ubiquitination | score1 | PhosphoSitePlus | |||
| Y23 | Phosphorylation | score1 | PhosphoSitePlus | |||
| R26 | Methylation | score1 | PhosphoSitePlus | |||
| S168 | Phosphorylation | score2 | PhosphoSitePlus UniProt | 19369195 | ||
| S174 | Phosphorylation | score3 | PhosphoSitePlus UniProt | 28545134 | ||
| S176 | Phosphorylation | score4 | neXtProt phospho.ELM PhosphoSitePlus RLIMS-P Signor UniProt | 17525332, 16824733, 27830463, ... | ||
| S176 | Phosphorylation | O43353 (RIPK2) | score3 | neXtProt PhosphoSitePlus Signor UniProt | 16824733 | |
| S178 | Phosphorylation | score3 | PhosphoSitePlus UniProt | 28545134 | ||
| S180 | Phosphorylation | score3 | PhosphoSitePlus UniProt | 28545134 | ||
| S181 | Phosphorylation | score3 | PhosphoSitePlus UniProt | 28545134 | ||
| K182 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K203 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K209 | Ubiquitination | score3 | PRO PhosphoSitePlus UniProt | 18079694 | ||
| S319 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S345 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S357 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S363 | Phosphorylation | score2 | PhosphoSitePlus UniProt | 18691976, 23186163, 19369195 | ||
| S374 | Phosphorylation | score1 | PhosphoSitePlus | |||
| Y381 | Phosphorylation | score3 | neXtProt PhosphoSitePlus UniProt | 21887730 | ||
| Y381 | Phosphorylation | P12931 (SRC) | score2 | neXtProt | 21887730 | |
| K384 | Methylation | score1 | PhosphoSitePlus | |||
| C388 | Methylation | score1 | IEDB | 31844290 | ||
| S393 | Phosphorylation | score2 | PhosphoSitePlus UniProt | 19369195 | ||
| S399 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K410 | Ubiquitination | score3 | PhosphoSitePlus UniProt | 29452636 | ||
| T411 | Phosphorylation | score1 | PhosphoSitePlus | |||
| T412 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S428 | Phosphorylation | score1 | PhosphoSitePlus | |||
| Y474 | Phosphorylation | score4 | neXtProt PhosphoSitePlus RLIMS-P UniProt | 24658576, 21123652, 31350258 | ||
| Y474 | Phosphorylation | O43353 (RIPK2) | score3 | neXtProt PhosphoSitePlus UniProt | 21123652 | |
| K480 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K503 | Ubiquitination | score2 | UniProt | 28656966 | ||
| K508 | Ubiquitination | score1 | PhosphoSitePlus | |||
| S527 | Phosphorylation | score2 | PhosphoSitePlus UniProt | 18691976, 23186163, 19369195 | ||
| S529 | Phosphorylation | score2 | PhosphoSitePlus UniProt | 23186163, 20068231 | ||
| S531 | Phosphorylation | score2 | phospho.ELM PhosphoSitePlus UniProt | 18669648, 23186163, 17192257 | ||
| K538 | Ubiquitination | score3 | PhosphoSitePlus UniProt | 29452636 | ||
| S539 | Phosphorylation | score2 | PhosphoSitePlus UniProt | 18691976, 19369195 |
|
Site | PTM Type | PTM Enzyme | Score | Source | PMID |
|---|---|---|---|---|---|---|
| S168 | Phosphorylation | score0 | HPRD | 18691976 | ||
| S176 | Phosphorylation | score0 | HPRD | 18691976, 17525332, 20068231 | ||
| S178 | Phosphorylation | score0 | HPRD | 18691976 | ||
| S345 | Phosphorylation | score0 | HPRD | 18691976 | ||
| S348 | Phosphorylation | score0 | HPRD | 18691976 | ||
| S363 | Phosphorylation | score0 | HPRD | 18691976 | ||
| Y381 | Phosphorylation | score0 | HPRD | 19901323 | ||
| Y474 | Phosphorylation | score0 | HPRD | 18691976 | ||
| T482 | Phosphorylation | score0 | HPRD | 18691976 | ||
| Y520 | Phosphorylation | score0 | HPRD | 18691976 | ||
| S527 | Phosphorylation | score0 | HPRD | 18691976, 20068231 | ||
| S529 | Phosphorylation | score0 | HPRD | 18691976, 20068231 | ||
| S531 | Phosphorylation | score0 | HPRD | 18691976, 18669648, 20058876, ... | ||
| S539 | Phosphorylation | score0 | HPRD | 18691976 |
O43353 (RIPK2) as PTM Enzyme
Proteoforms
| PRO ID (Short Label) | Sites | PTM Enzyme | Source | PMID | |
|---|---|---|---|---|---|
| PR:000049046 (hRIPK2/Ubiq:1) | ubK209 | PRO |
PTM sites affected in variants
| Site | Variant | Source | PMID | Disease [Sample source] |
|---|---|---|---|---|
| S174 | P174 | Biomuta | DOID:363 / uterine cancer [ cosmic, icgc ] | |
| S181 | N181 | Biomuta | DOID:1793 / pancreatic cancer [ cosmic ] | |
| S319 | I319 | Biomuta | DOID:9256 / colorectal cancer [ cosmic ] DOID:263 / kidney cancer [ cosmic, icgc ] | |
| S348 | F348 | Biomuta | DOID:4159 / skin cancer [ cosmic ] | |
| S374 | C374 | Biomuta | DOID:1612 / breast cancer [ cosmic ] | |
| K384 | E384 | Biomuta | DOID:3571 / liver cancer [ cosmic, icgc ] | |
| K384 | R384 | Biomuta | DOID:10283 / prostate cancer [ cosmic ] | |
| S393 | N393 | Biomuta | DOID:9256 / colorectal cancer [ cosmic ] | |
| S428 | L428 | Biomuta | DOID:263 / kidney cancer [ cosmic ] | |
| K503 | E503 | Biomuta | DOID:9256 / colorectal cancer [ cosmic, icgc ] | |
| S527 | C527 | Biomuta | DOID:5041 / esophageal cancer [ cosmic ] | |
| S529 | T529 | Biomuta | DOID:2394 / ovarian cancer [ cosmic ] | |
| S529 | L529 | Biomuta | DOID:11054 / urinary bladder cancer [ cosmic, icgc ] | |
| S529 | P529 | Biomuta | DOID:10283 / prostate cancer [ cosmic, icgc ] |
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