iPTMnet Report for O43314 (PPIP5K2)


Protein Information

Cytoscape View


UniProt AC / UniProt ID O43314 / VIP2_HUMAN
Protein Name Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2
Gene Name Name: PPIP5K2
Synonyms:HISPPD1,KIAA0433,VIP2;
Organism Homo sapiens (Human)

PRO ID PR:O43314
DAG View
PRO Name inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 (human)
Definition An inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 that is encoded in the genome of human.
Short Label hPPIP5K2
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


O43314 (PPIP5K2) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
T14 Phosphorylation PhosphoSitePlus
Y21 Phosphorylation PhosphoSitePlus
S38 Phosphorylation PhosphoSitePlus   UniProt 23186163, 19690332, 24275569
S50 Phosphorylation PhosphoSitePlus
S55 Phosphorylation PhosphoSitePlus
K61 Acetylation PhosphoSitePlus
K115 Ubiquitination PhosphoSitePlus
S223 Phosphorylation PhosphoSitePlus   UniProt 23186163
K230 Ubiquitination PhosphoSitePlus
K248 Acetylation PhosphoSitePlus
Y256 Phosphorylation PhosphoSitePlus
K263 Ubiquitination PhosphoSitePlus
K270 Acetylation PhosphoSitePlus
K270 Ubiquitination PhosphoSitePlus
C298 Methylation IEDB 31844290
C306 Methylation IEDB 31844290
K333 Ubiquitination PhosphoSitePlus
Y334 Phosphorylation PhosphoSitePlus
Y335 Phosphorylation PhosphoSitePlus
K406 Ubiquitination PhosphoSitePlus
T491 Phosphorylation PhosphoSitePlus
S493 Phosphorylation PhosphoSitePlus
S498 Phosphorylation PhosphoSitePlus
S504 Phosphorylation PhosphoSitePlus
K561 Ubiquitination PhosphoSitePlus
T573 Phosphorylation PhosphoSitePlus
T589 Phosphorylation PhosphoSitePlus
K629 Ubiquitination PhosphoSitePlus
K640 Ubiquitination PhosphoSitePlus
S648 Phosphorylation PhosphoSitePlus
Y727 Phosphorylation PhosphoSitePlus
C729 Methylation IEDB 31844290
K768 Ubiquitination PhosphoSitePlus
Y778 Phosphorylation PhosphoSitePlus
T780 Phosphorylation PhosphoSitePlus
S788 Phosphorylation PhosphoSitePlus
K801 Ubiquitination PhosphoSitePlus
Y806 Phosphorylation PhosphoSitePlus
S807 Phosphorylation PhosphoSitePlus
S894 Phosphorylation PhosphoSitePlus
K926 Ubiquitination PhosphoSitePlus
S962 Phosphorylation PhosphoSitePlus
S977 Phosphorylation PhosphoSitePlus
S982 Phosphorylation PhosphoSitePlus
Y993 Phosphorylation PhosphoSitePlus
T999 Phosphorylation PhosphoSitePlus
S1006 Phosphorylation PhosphoSitePlus   UniProt 18669648, 23186163, 24275569
T1011 Phosphorylation PhosphoSitePlus
S1012 Phosphorylation PhosphoSitePlus
S1013 Phosphorylation PhosphoSitePlus
S1016 Phosphorylation PhosphoSitePlus   UniProt 18669648, 23186163
S1029 Phosphorylation PhosphoSitePlus
S1074 Phosphorylation PhosphoSitePlus   UniProt 23186163
S1091 Phosphorylation PhosphoSitePlus   UniProt 23186163, 24275569
R1100 Methylation PhosphoSitePlus
S1108 Phosphorylation PhosphoSitePlus
S1110 Phosphorylation PhosphoSitePlus
S1152 Phosphorylation PhosphoSitePlus
K1160 Ubiquitination PhosphoSitePlus
S1165 Phosphorylation PhosphoSitePlus   UniProt 23186163
T1167 Phosphorylation PhosphoSitePlus
S1171 Phosphorylation PhosphoSitePlus
S1172 Phosphorylation PhosphoSitePlus   UniProt 18669648, 23186163
S1180 Phosphorylation PhosphoSitePlus   UniProt 23186163
T1183 Phosphorylation PhosphoSitePlus
Y1184 Phosphorylation PhosphoSitePlus
T1185 Phosphorylation PhosphoSitePlus
T1192 Phosphorylation PhosphoSitePlus
K1198 Methylation PhosphoSitePlus
S1199 Phosphorylation PhosphoSitePlus
K1201 Methylation PhosphoSitePlus
S1209 O-Glycosylation GlyGen 31492838
S1220 Phosphorylation PhosphoSitePlus   UniProt 23186163
S1221 Phosphorylation PhosphoSitePlus   UniProt 23186163
Site PTM Type PTM Enzyme Score Source PMID
S38 Phosphorylation HPRD 19651622, 20166139, 18669648, ...18452278
T491 Phosphorylation HPRD 19651622
S492 Phosphorylation HPRD 19651622
S504 Phosphorylation HPRD 17924679
S694 Phosphorylation HPRD 20068231
S1006 Phosphorylation HPRD 19651622, 18669648, 19664994
S1012 Phosphorylation HPRD 19651622, 18669648
S1016 Phosphorylation HPRD 19651622, 18669648
S1150 Phosphorylation HPRD 18767875, 18669648
S1151 Phosphorylation HPRD 18669648
T1164 Phosphorylation HPRD 16964243


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
Y21 F21 Biomuta DOID:3571 / liver cancer [ cosmic ]
S55 F55 Biomuta DOID:4159 / skin cancer [ cosmic ]
S492 Y492 Biomuta DOID:10534 / stomach cancer [ cosmic ]
S492 A492 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
S493 T493 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S498 N498 Biomuta DOID:1319 / brain cancer [ cosmic, icgc ]
S648 Y648 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
Y727 C727 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S788 L788 Biomuta DOID:10283 / prostate cancer [ cosmic ]
Y806 C806 Biomuta DOID:263 / kidney cancer [ cosmic, icgc ]
K926 T926 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
T999 A999 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ] DOID:1612 / breast cancer [ cosmic, icgc ] DOID:10534 / stomach cancer [ cosmic, icgc ] DOID:1324 / lung cancer [ cosmic ] DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
S1006 L1006 Biomuta DOID:1324 / lung cancer [ cosmic ]
S1016 Y1016 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
S1016 F1016 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
R1100 C1100 Biomuta DOID:3571 / liver cancer [ cosmic ]
K1160 N1160 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
S1180 F1180 Biomuta DOID:8618 / oral cavity cancer [ cosmic ] DOID:11934 / head and neck cancer [ icgc ]
T1183 M1183 Biomuta DOID:8618 / oral cavity cancer [ cosmic ]
K1198 N1198 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
S1220 L1220 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]