iPTMnet Report for O43307 (ARHGEF9)


Protein Information

Cytoscape View


UniProt AC / UniProt ID O43307 / ARHG9_HUMAN
Protein Name Rho guanine nucleotide exchange factor 9
Gene Name Name: ARHGEF9
Synonyms:ARHDH9,KIAA0424;
Organism Homo sapiens (Human)

PRO ID PR:O43307
DAG View
PRO Name Rho guanine nucleotide exchange factor 9 (human)
Definition A Rho guanine nucleotide exchange factor 9 that is encoded in the genome of human.
Short Label hARHGEF9
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


O43307 (ARHGEF9) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
T2 Phosphorylation PhosphoSitePlus
S41 Phosphorylation PhosphoSitePlus
C90 Methylation IEDB 31844290
R116 Methylation PhosphoSitePlus
K131 Methylation PhosphoSitePlus
K408 Ubiquitination PhosphoSitePlus
K413 Ubiquitination PhosphoSitePlus
S502 Phosphorylation PhosphoSitePlus
K515 Ubiquitination PhosphoSitePlus
K516 Ubiquitination PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
T2 K2 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
S41 F41 Biomuta DOID:4159 / skin cancer [ cosmic ]
C90 F90 Biomuta DOID:1324 / lung cancer [ cosmic ]
R116 C116 Biomuta DOID:5041 / esophageal cancer [ cosmic ]
K131 T131 Biomuta DOID:1319 / brain cancer [ cosmic, icgc ]
K131 * Biomuta DOID:4159 / skin cancer [ cosmic ]