Protein Information

Cytoscape View


UniProt AC / UniProt ID O43295 / SRGP3_HUMAN
Protein Name SLIT-ROBO Rho GTPase-activating protein 3
Gene Name Name: SRGAP3
Synonyms:ARHGAP14,KIAA0411,KIAA1156,MEGAP,SRGAP2;
Organism Homo sapiens (Human)

PRO ID PR:O43295
DAG View
PRO Name SLIT-ROBO Rho GTPase-activating protein 3 (human)
Definition A SLIT-ROBO Rho GTPase-activating protein 3 that is encoded in the genome of human.
Short Label hSRGAP3
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


O43295 (SRGAP3) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K6 Ubiquitination PhosphoSitePlus
Y17 Phosphorylation PhosphoSitePlus
Y63 Phosphorylation PhosphoSitePlus
S80 Phosphorylation PhosphoSitePlus
K141 Methylation PhosphoSitePlus
T157 Phosphorylation PhosphoSitePlus
Y161 Phosphorylation PhosphoSitePlus
S214 Phosphorylation PhosphoSitePlus
K220 Acetylation PhosphoSitePlus
K222 Acetylation PhosphoSitePlus
K224 Acetylation PhosphoSitePlus
Y359 Phosphorylation PhosphoSitePlus
T392 Phosphorylation PhosphoSitePlus
S399 Phosphorylation PhosphoSitePlus
S407 Phosphorylation PhosphoSitePlus
S413 Phosphorylation PhosphoSitePlus
Y446 Phosphorylation PhosphoSitePlus
K455 Ubiquitination PhosphoSitePlus
K459 Acetylation PhosphoSitePlus
K464 Acetylation PhosphoSitePlus
S497 Phosphorylation PhosphoSitePlus
K554 Ubiquitination PhosphoSitePlus
S602 Phosphorylation phospho.ELM   PhosphoSitePlus 18088087
Y755 Phosphorylation PhosphoSitePlus
S759 Phosphorylation PhosphoSitePlus
S764 Phosphorylation PhosphoSitePlus
S770 Phosphorylation PhosphoSitePlus
S837 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648
Y845 Phosphorylation PhosphoSitePlus
S858 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S868 Phosphorylation PhosphoSitePlus
S874 Phosphorylation PhosphoSitePlus
S895 Phosphorylation PhosphoSitePlus
S908 Phosphorylation PhosphoSitePlus
S919 Phosphorylation PhosphoSitePlus
S922 Phosphorylation PhosphoSitePlus
S948 Phosphorylation PhosphoSitePlus
S954 Phosphorylation PhosphoSitePlus
T983 Phosphorylation PhosphoSitePlus
S1011 Phosphorylation PhosphoSitePlus
S1030 Phosphorylation PhosphoSitePlus
S1070 Phosphorylation PhosphoSitePlus
S1071 Phosphorylation PhosphoSitePlus
S1078 Phosphorylation PhosphoSitePlus
T1082 Phosphorylation PhosphoSitePlus
S1092 Phosphorylation PhosphoSitePlus
T1098 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S602 Phosphorylation HPRD 18088087
S837 Phosphorylation HPRD 18669648
S858 Phosphorylation HPRD 18669648
Site PTM Type PTM Enzyme Score Source PMID
S578 Phosphorylation HPRD 18088087
S813 Phosphorylation HPRD 18669648
S834 Phosphorylation HPRD 18669648


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S407 L407 Biomuta DOID:8618 / oral cavity cancer [ icgc ]
S413 L413 Biomuta DOID:363 / uterine cancer [ tcga ] DOID:9256 / colorectal cancer [ tcga ]
K554 Q554 Biomuta DOID:1324 / lung cancer [ cosmic ]
S770 L770 Biomuta DOID:1324 / lung cancer [ cosmic, icgc, tcga ]
S837 F837 Biomuta DOID:1790 / malignant mesothelioma [ tcga ] DOID:1909 / melanoma [ tcga ]
S922 I922 Biomuta DOID:9256 / colorectal cancer [ tcga ]
S954 Y954 Biomuta DOID:3963 / thyroid carcinoma [ cosmic, icgc ]
T983 M983 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc, tcga ]
T1082 M1082 Biomuta DOID:1324 / lung cancer [ cosmic ]