iPTMnet Report for O43294 (TGFB1I1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID O43294 / TGFI1_HUMAN
Protein Name Transforming growth factor beta-1-induced transcript 1 protein
Gene Name Name: TGFB1I1
Synonyms:ARA55;
Organism Homo sapiens (Human)

PRO ID PR:O43294
DAG View
PRO Name transforming growth factor beta-1-induced transcript 1 protein (human)
Definition A transforming growth factor beta-1-induced transcript 1 protein that is encoded in the genome of human.
Short Label hTGFB1I1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


O43294 (TGFB1I1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
M1 Acetylation UniProt 22814378
S9 Phosphorylation PhosphoSitePlus
T33 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18691976, 17081983, 24275569
S37 Phosphorylation PhosphoSitePlus
Y38 Phosphorylation PhosphoSitePlus   RLIMS-P 16764713, 22529104, 30893012
Y60 Phosphorylation Q14289 (PTK2B) , P06241 (FYN) neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 16764713, 22529104, 11856738, ...30893012, 10838081
S61 Phosphorylation PhosphoSitePlus
T62 Phosphorylation PhosphoSitePlus
S68 Phosphorylation IEDB   phospho.ELM   PhosphoSitePlus   UniProt 17081983, 32157095, 24275569, ...31848261, 27869121
S80 O-Glycosylation GlyGen 31492838, 34019948, 35254053
S81 O-Glycosylation GlyGen 31492838, 34019948, 35254053
S122 Phosphorylation phospho.ELM   PhosphoSitePlus 17287340
S130 Phosphorylation PhosphoSitePlus
S137 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 21406692, 23186163, 17081983, ...24275569
S140 Phosphorylation PhosphoSitePlus   UniProt 24275569
S141 Phosphorylation P28482 (MAPK1) neXtProt   PhosphoSitePlus   UniProt 22028470, 23186163
S143 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 17081983, 24275569
S150 Phosphorylation PhosphoSitePlus
S153 Phosphorylation PhosphoSitePlus
S164 Phosphorylation PhosphoSitePlus   UniProt 23186163
S166 Phosphorylation PhosphoSitePlus
S187 Phosphorylation PhosphoSitePlus
T188 Phosphorylation phospho.ELM   PhosphoSitePlus 17081983
S192 Phosphorylation PhosphoSitePlus   UniProt 23186163, 24275569
S194 Phosphorylation PhosphoSitePlus   UniProt 23186163
T199 Phosphorylation PhosphoSitePlus
S203 Phosphorylation PhosphoSitePlus
S213 Phosphorylation PhosphoSitePlus
S216 Phosphorylation PhosphoSitePlus
S403 Phosphorylation PhosphoSitePlus   UniProt 24275569
T407 Phosphorylation PhosphoSitePlus   UniProt 24275569
S418 Phosphorylation PhosphoSitePlus
K449 Ubiquitination PhosphoSitePlus
K458 Ubiquitination PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
T33 Phosphorylation HPRD 19651622, 18691976
T44 Phosphorylation HPRD 17081983
S49 Phosphorylation HPRD 17081983
S53 Phosphorylation HPRD 17081983
S68 Phosphorylation HPRD 19651622, 17081983
S82 Phosphorylation HPRD 18691976
S122 Phosphorylation HPRD 17287340
S137 Phosphorylation HPRD 19651622, 20166139
S140 Phosphorylation HPRD 19651622, 20166139, 17081983
S141 Phosphorylation HPRD 19651622, 20166139, 17081983
S143 Phosphorylation HPRD 19651622, 20166139, 17081983
S186 Phosphorylation HPRD 17081983
S187 Phosphorylation HPRD 17081983
S192 Phosphorylation HPRD 20166139, 18691976
S194 Phosphorylation HPRD 18691976
S403 Phosphorylation HPRD 20166139
Site PTM Type PTM Enzyme Score Source PMID
T16 Phosphorylation HPRD 19651622, 18691976
T27 Phosphorylation HPRD 17081983
S32 Phosphorylation HPRD 17081983
S36 Phosphorylation HPRD 17081983
S51 Phosphorylation HPRD 19651622, 17081983
S65 Phosphorylation HPRD 18691976
S105 Phosphorylation HPRD 17287340
S120 Phosphorylation HPRD 19651622, 20166139
S123 Phosphorylation HPRD 19651622, 20166139, 17081983
S124 Phosphorylation HPRD 19651622, 20166139, 17081983
S126 Phosphorylation HPRD 19651622, 20166139, 17081983
S169 Phosphorylation HPRD 17081983
S170 Phosphorylation HPRD 17081983
S175 Phosphorylation HPRD 20166139, 18691976
S177 Phosphorylation HPRD 18691976
S386 Phosphorylation HPRD 20166139


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
T62 K62 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
T62 M62 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
S80 F80 Biomuta DOID:4159 / skin cancer [ cosmic ] DOID:1324 / lung cancer [ cosmic, icgc ]
S153 L153 Biomuta DOID:8618 / oral cavity cancer [ cosmic ]
S169 R169 Biomuta DOID:3571 / liver cancer [ cosmic, icgc ]
S186 R186 Biomuta DOID:3571 / liver cancer [ cosmic, icgc ]
S203 T203 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
S213 F213 Biomuta DOID:2394 / ovarian cancer [ cosmic, icgc ]
K458 M458 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]