iPTMnet Report O43293 DAPK3

Protein Information

UniProt AC / UniProt ID	O43293 / DAPK3_HUMAN
Protein Name	Death-associated protein kinase 3
Gene Name	Name: DAPK3 Synonyms:ZIPK;
Organism	Homo sapiens (Human)

PRO ID	PR:O43293 DAG View
PRO Name	death-associated protein kinase 3 (human)
Definition	A death-associated protein kinase 3 that is encoded in the genome of human.
Short Label	hDAPK3
Category	organism-gene

Interactive Sequence View

	Select/align proteoforms across species

O43293 (DAPK3) as Substrate

O43293

Expanded View

Search:

Site Select all By amino acid All Serine All Threonine All Tyrosine By position K37 Y39 S50 T112 K121 K133 K141 K150 K167 T180 T225 T265 K276 T299 K303 Y305 T306 K308 S309 S311 S312 S318 S326 K327 C349 K363 K387 T388 K400 S407 K410 S414 K425 K445 R454	PTM Type Select all Methylation Phosphorylation Ubiquitination	PTM Enzyme	Score Select all 1 2 3 4	Source Select all IEDB PRO PhosphoSitePlus RLIMS-P Signor UniProt neXtProt phospho.ELM	PMID
K37	Methylation		score1	PhosphoSitePlus
Y39	Phosphorylation		score1	PhosphoSitePlus
S50	Phosphorylation	O43293 (DAPK3)	score3	neXtProt PhosphoSitePlus UniProt	18239682
T112	Phosphorylation		score1	PhosphoSitePlus
K121	Ubiquitination		score1	PhosphoSitePlus
K133	Ubiquitination		score1	PhosphoSitePlus
K141	Ubiquitination		score1	PhosphoSitePlus
K150	Ubiquitination		score1	PhosphoSitePlus
K167	Ubiquitination		score1	PhosphoSitePlus
T180	Phosphorylation	O43293 (DAPK3)	score4	neXtProt phospho.ELM PhosphoSitePlus RLIMS-P Signor UniProt	15611134, 17158456
T225	Phosphorylation	O43293 (DAPK3)	score4	neXtProt phospho.ELM PhosphoSitePlus RLIMS-P Signor UniProt	15611134, 17158456
T265	Phosphorylation	Q13464 (ROCK1) , O43293 (DAPK3)	score4	neXtProt phospho.ELM PhosphoSitePlus RLIMS-P Signor UniProt	17158456, 32306542, 18239682, ...27573465, 18515077, 15611134, 16325270
K276	Ubiquitination		score1	PhosphoSitePlus
T299	Phosphorylation	P53355 (DAPK1) , O43293 (DAPK3) , Q13464 (ROCK1)	score4	neXtProt phospho.ELM PhosphoSitePlus RLIMS-P Signor UniProt	15611134, 17158456, 20854903, ...15367680
K303	Ubiquitination		score1	PhosphoSitePlus
Y305	Phosphorylation		score1	PhosphoSitePlus
T306	Phosphorylation	O43293 (DAPK3)	score3	neXtProt phospho.ELM PhosphoSitePlus RLIMS-P Signor UniProt	15611134
K308	Ubiquitination		score1	PhosphoSitePlus
S309	Phosphorylation	P53355 (DAPK1)	score3	neXtProt PRO PhosphoSitePlus UniProt	15367680
S311	Phosphorylation	P53355 (DAPK1) , O43293 (DAPK3)	score4	neXtProt phospho.ELM PRO PhosphoSitePlus RLIMS-P Signor UniProt	15611134, 17158456, 15367680
S312	Phosphorylation	P53355 (DAPK1)	score4	neXtProt PRO PhosphoSitePlus UniProt	23186163, 15367680
S318	Phosphorylation	P53355 (DAPK1)	score3	neXtProt PRO UniProt	15367680
S326	Phosphorylation	P53355 (DAPK1)	score3	neXtProt PRO UniProt	15367680
K327	Ubiquitination		score1	PhosphoSitePlus
C349	Methylation		score1	IEDB	31844290
K363	Ubiquitination		score1	PhosphoSitePlus
K387	Ubiquitination		score1	PhosphoSitePlus
T388	Phosphorylation		score1	PhosphoSitePlus
K400	Ubiquitination		score1	PhosphoSitePlus
S407	Phosphorylation		score1	PhosphoSitePlus
K410	Ubiquitination		score1	PhosphoSitePlus
S414	Phosphorylation		score2	IEDB PhosphoSitePlus	27920218
K425	Ubiquitination		score1	PhosphoSitePlus
K445	Ubiquitination		score1	PhosphoSitePlus
R454	Methylation		score1	PhosphoSitePlus

Search:

Substrate Select all O14950 (MYL12B) O43293 (DAPK3) P04637 (TP53) P24844 (MYL9) P38936 (CDKN1A) P40429 (RPL13A) P40763 (STAT3) P68431 (H3C12) Q00987 (MDM2) Q96A00 (PPP1R14A)	Site Select all By amino acid All Serine All Threonine By position T12 S12 T19 S20 T38 S50 S77 T145 S166 T180 S186 T225 T265 T299 T306 S311 S727	Score Select all 2 3 4	Source Select all HPRD PhosphoSitePlus Signor UniProt neXtProt phospho.ELM	PMID
O14950 (MYL12B)	T19	score4	neXtProt PhosphoSitePlus Signor	12429016, 11781833, 10356987, ...1178183
O14950 (MYL12B)	S20	score4	neXtProt PhosphoSitePlus Signor	11781833, 10356987, 1178183
O43293 (DAPK3)	S50	score3	neXtProt UniProt	18239682
O43293 (DAPK3)	T180	score3	neXtProt phospho.ELM PhosphoSitePlus Signor	15611134
O43293 (DAPK3)	T225	score4	neXtProt phospho.ELM PhosphoSitePlus Signor	15611134, 17158456
O43293 (DAPK3)	T265	score4	neXtProt phospho.ELM PhosphoSitePlus Signor UniProt	15611134, 17158456
O43293 (DAPK3)	T299	score4	neXtProt phospho.ELM PhosphoSitePlus Signor UniProt	15611134, 17158456, 15367680
O43293 (DAPK3)	T306	score3	neXtProt phospho.ELM PhosphoSitePlus Signor UniProt	15611134
O43293 (DAPK3)	S311	score4	neXtProt phospho.ELM PhosphoSitePlus Signor UniProt	15611134, 17158456, 15367680
P04637 (TP53)	S20	score3	PhosphoSitePlus Signor	17339337
P24844 (MYL9)	T19	score4	phospho.ELM Signor	15096528, 19851336
P24844 (MYL9)	S20	score4	phospho.ELM Signor	10356987, 19851336
P38936 (CDKN1A)	T145	score3	HPRD neXtProt PhosphoSitePlus	15001356
P40429 (RPL13A)	S77	score4	phospho.ELM PhosphoSitePlus Signor	18995835, 22771119, 23071094
P40763 (STAT3)	S727	score2	neXtProt	16219639
P68431 (H3C12)	T12	score2	phospho.ELM	12560483
Q00987 (MDM2)	S166	score3	neXtProt phospho.ELM PhosphoSitePlus Signor	15001356
Q00987 (MDM2)	S186	score2	PhosphoSitePlus	15001356
Q96A00 (PPP1R14A)	S12	score3	phospho.ELM PhosphoSitePlus	11287002
Q96A00 (PPP1R14A)	T38	score2	PhosphoSitePlus	11287002

Search:

PRO ID (Short Label) Select all PR:000037783 (hRPL13A/InitMet-/AcPhos:1)	Sites Select all acA2,pS77	PTM Enzyme	Source Select all PRO	PMID
PR:000037783 (hRPL13A/InitMet-/AcPhos:1)	acA2,pS77	PR:000037784 (hDAPK3/Phos:1)	PRO	12962325, 18995835

Proteoforms

Search:

	PRO ID (Short Label) Select all PR:000037784 (hDAPK3/Phos:1)	Sites Select all pS309,pS311,pS312,pS318,pS326	PTM Enzyme	Source Select all PRO	PMID
	PR:000037784 (hDAPK3/Phos:1)	pS309,pS311,pS312,pS318,pS326		PRO	15367680

PTM sites affected in variants

Search:

Site Select all By amino acid All Serine All Threonine All Tyrosine By position T112 K141 T180 T225 Y305 S309 K327 R454	Variant Select all C305 C454 H305 I180 L309 M112 M225 M327 Q141	Source Select all Biomuta	Disease [Sample source] Select all DOID:2394 / ovarian cancer [ cosmic, icgc, tcga ] DOID:2531 / hematologic cancer [ cosmic ] DOID:363 / uterine cancer [ icgc ] DOID:4159 / skin cancer [ cosmic ] DOID:9256 / colorectal cancer [ cosmic ] DOID:9256 / colorectal cancer [ cosmic ] DOID:10283 / prostate cancer [ cosmic ] DOID:9256 / colorectal cancer [ cosmic, icgc ]
T112	M112	Biomuta	DOID:9256 / colorectal cancer [ cosmic ] DOID:10283 / prostate cancer [ cosmic ]
K141	Q141	Biomuta	DOID:9256 / colorectal cancer [ cosmic, icgc ]
T180	I180	Biomuta	DOID:4159 / skin cancer [ cosmic ]
T225	M225	Biomuta	DOID:9256 / colorectal cancer [ cosmic ]
Y305	H305	Biomuta	DOID:2531 / hematologic cancer [ cosmic ]
Y305	C305	Biomuta	DOID:9256 / colorectal cancer [ cosmic ]
S309	L309	Biomuta	DOID:363 / uterine cancer [ icgc ]
K327	M327	Biomuta	DOID:2394 / ovarian cancer [ cosmic, icgc, tcga ]
R454	C454	Biomuta	DOID:9256 / colorectal cancer [ cosmic ]

PTM Type		Select All, None
Acetylation	N-Glycosylation	O-Glycosylation
C-Glycosylation	S-Glycosylation	Methylation
Myristoylation	Phosphorylation	Sumoylation
Ubiquitination	S-Nitrosylation

Select organisms		Select All, None
Human	Mouse	Rat
Cow	Chicken	Zebrafish
Fruit fly	C. elegans	Baker's yeast
Fission yeast	A. thaliana	Maize
M. truncatula	Rice (japonica)	Rice (indica)

Or input other organisms

iPTMnet Report for O43293 (DAPK3)

Protein Information

Interactive Sequence View

O43293 (DAPK3) as Substrate

O43293 (DAPK3) as PTM Enzyme

Proteoforms

PTM sites affected in variants