iPTMnet Report for O43281 (EFS)


Protein Information

Cytoscape View


UniProt AC / UniProt ID O43281 / EFS_HUMAN
Protein Name Embryonal Fyn-associated substrate
Gene Name Name: EFS
Synonyms:CASS3;
Organism Homo sapiens (Human)

PRO ID PR:O43281
DAG View
PRO Name embryonal Fyn-associated substrate (human)
Definition An embryonal Fyn-associated substrate that is encoded in the genome of human.
Short Label hEFS
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


O43281 (EFS) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S20 Phosphorylation PhosphoSitePlus
S123 Phosphorylation PhosphoSitePlus
Y128 Phosphorylation PhosphoSitePlus
Y148 Phosphorylation PhosphoSitePlus
S160 Phosphorylation PhosphoSitePlus
Y163 Phosphorylation PhosphoSitePlus
Y188 Phosphorylation PhosphoSitePlus
T193 Phosphorylation PhosphoSitePlus
Y217 Phosphorylation PhosphoSitePlus
S287 Phosphorylation PhosphoSitePlus
S298 Phosphorylation PhosphoSitePlus
S317 Phosphorylation PhosphoSitePlus
S319 Phosphorylation PhosphoSitePlus
S323 Phosphorylation PhosphoSitePlus
S331 Phosphorylation PhosphoSitePlus
Y372 Phosphorylation PhosphoSitePlus
Y381 Phosphorylation PhosphoSitePlus
Y383 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S298 Phosphorylation HPRD 19664994
Site PTM Type PTM Enzyme Score Source PMID
S30 Phosphorylation PhosphoSitePlus
S205 Phosphorylation HPRD 19664994


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S287 I287 Biomuta DOID:1324 / lung cancer [ cosmic ]
S319 P319 Biomuta DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ]
Y381 C381 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
Y383 H383 Biomuta DOID:1781 / thyroid gland cancer [ cosmic ]