iPTMnet Report for O43278 (SPINT1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID O43278 / SPIT1_HUMAN
Protein Name Kunitz-type protease inhibitor 1 precursor
Gene Name Name: SPINT1
Synonyms:HAI1;ORFNames:UNQ223/PRO256;
Organism Homo sapiens (Human)

PRO ID PR:O43278
DAG View
PRO Name Kunitz-type protease inhibitor 1 (human)
Definition A Kunitz-type protease inhibitor 1 that is encoded in the genome of human.
Short Label hSPINT1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


O43278 (SPINT1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S160 Phosphorylation PhosphoSitePlus
K172 Ubiquitination PhosphoSitePlus
S277 Phosphorylation phospho.ELM 18669648
S312 O-Glycosylation GlyGen 25813380
T317 O-Glycosylation GlyGen 30459171
S323 O-Glycosylation GlyGen 25813380
T334 O-Glycosylation GlyGen 30459171
T373 O-Glycosylation GlyGen 30459171
T505 Phosphorylation PhosphoSitePlus
S508 Phosphorylation PhosphoSitePlus
T510 Phosphorylation PhosphoSitePlus
S512 Phosphorylation PhosphoSitePlus
T514 Phosphorylation PhosphoSitePlus
Y522 Phosphorylation PhosphoSitePlus
T526 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S277 Phosphorylation HPRD 18669648
Site PTM Type PTM Enzyme Score Source PMID
S277 Phosphorylation HPRD 18669648


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S160 Y160 Biomuta DOID:1319 / brain cancer [ cosmic ]
S323 P323 Biomuta DOID:10534 / stomach cancer [ cosmic ]
T373 S373 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
T373 M373 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]