iPTMnet Report for O43264 (ZW10)


Protein Information

Cytoscape View


UniProt AC / UniProt ID O43264 / ZW10_HUMAN
Protein Name Centromere/kinetochore protein zw10 homolog
Gene Name Name: ZW10
Organism Homo sapiens (Human)

PRO ID PR:O43264
DAG View
PRO Name centromere/kinetochore protein zw10 homolog (human)
Definition A centromere/kinetochore protein zw10 that is encoded in the genome of human.
Short Label hZW10
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


O43264 (ZW10) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
A2 Acetylation UniProt 19413330, 25944712
S3 Phosphorylation PhosphoSitePlus   UniProt 23186163
S12 Phosphorylation PhosphoSitePlus   UniProt 23186163
K17 Ubiquitination PhosphoSitePlus
T22 Phosphorylation PhosphoSitePlus
K74 Ubiquitination PhosphoSitePlus
T89 Phosphorylation PhosphoSitePlus
K96 Ubiquitination PhosphoSitePlus
S103 Phosphorylation PhosphoSitePlus
K129 Ubiquitination PhosphoSitePlus
K130 Ubiquitination PhosphoSitePlus
T133 Phosphorylation PhosphoSitePlus
K143 Ubiquitination PhosphoSitePlus
T314 O-Glycosylation GlyGen 23301498, 28411811, 34725712, ...29351928, 34019948, 28510447
Y349 Phosphorylation PhosphoSitePlus
K357 Ubiquitination PhosphoSitePlus
K376 Ubiquitination PhosphoSitePlus
K382 Ubiquitination PhosphoSitePlus
T386 Phosphorylation PhosphoSitePlus
K390 Ubiquitination PhosphoSitePlus
K402 Ubiquitination PhosphoSitePlus
K403 Ubiquitination PhosphoSitePlus
K424 Ubiquitination PhosphoSitePlus
K430 Ubiquitination PhosphoSitePlus
T438 Phosphorylation phospho.ELM   PhosphoSitePlus 16565220
K444 Ubiquitination PhosphoSitePlus
Y455 Phosphorylation PhosphoSitePlus
K484 Ubiquitination PhosphoSitePlus
K597 Ubiquitination PhosphoSitePlus
S611 Phosphorylation PhosphoSitePlus
K624 Ubiquitination PhosphoSitePlus
K687 Ubiquitination PhosphoSitePlus
K708 Ubiquitination PhosphoSitePlus
K777 Acetylation PhosphoSitePlus   UniProt 19608861
K777 Ubiquitination PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
T133 Phosphorylation HPRD 20068231
T386 Phosphorylation HPRD 19664994
T438 Phosphorylation HPRD 20068231, 16565220
S662 Phosphorylation HPRD 20068231


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
A2 T2 Biomuta DOID:363 / uterine cancer [ icgc ]
A2 V2 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
S3 P3 Biomuta [ cosmic ]
K96 R96 Biomuta DOID:363 / uterine cancer [ icgc ]
T133 N133 Biomuta DOID:1324 / lung cancer [ cosmic ]
T314 S314 Biomuta DOID:363 / uterine cancer [ icgc ]
Y455 F455 Biomuta [ cosmic ] DOID:1115 / sarcoma [ icgc ]
S662 A662 Biomuta DOID:9256 / colorectal cancer [ cosmic ]