iPTMnet Report for O43255 (SIAH2)


Protein Information

Cytoscape View


UniProt AC / UniProt ID O43255 / SIAH2_HUMAN
Protein Name E3 ubiquitin-protein ligase SIAH2
Gene Name Name: SIAH2
Organism Homo sapiens (Human)

PRO ID PR:O43255
DAG View
PRO Name E3 ubiquitin-protein ligase SIAH2 (human)
Definition An E3 ubiquitin-protein ligase SIAH2 that is encoded in the genome of human.
Short Label hSIAH2
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


O43255 (SIAH2) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S2 Phosphorylation PhosphoSitePlus
S6 Phosphorylation PhosphoSitePlus   RLIMS-P   UniProt 23186163, 33536006
T7 Phosphorylation PhosphoSitePlus
S10 Phosphorylation PhosphoSitePlus
K13 Ubiquitination PhosphoSitePlus
S16 Phosphorylation Q92630 (DYRK2) neXtProt   PhosphoSitePlus   Signor   UniProt 22878263
T26 Phosphorylation O96017 (CHEK2) , Q92630 (DYRK2) , Q9H2X6 (HIPK2) neXtProt   PhosphoSitePlus   Signor   UniProt 26751770, 22878263, 19043406
S28 Phosphorylation Q92630 (DYRK2) , O96017 (CHEK2) , Q16539 (MAPK14) , Q9H2X6 (HIPK2) neXtProt   PhosphoSitePlus   Signor   UniProt 26751770, 17003045, 22878263, ...19043406
S68 Phosphorylation Q9H2X6 (HIPK2) , Q92630 (DYRK2) , O96017 (CHEK2) neXtProt   PhosphoSitePlus   Signor   UniProt 19043406, 22878263, 26751770
K107 Ubiquitination PhosphoSitePlus
T119 Phosphorylation O96017 (CHEK2) , Q92630 (DYRK2) neXtProt   PhosphoSitePlus   Signor   UniProt 26751770, 22878263
S132 Phosphorylation PhosphoSitePlus
S167 Phosphorylation PhosphoSitePlus
T254 Phosphorylation PhosphoSitePlus
K256 Ubiquitination PhosphoSitePlus
T275 Phosphorylation RLIMS-P 33536006
T279 Phosphorylation PhosphoSitePlus   RLIMS-P 33536006
S282 Phosphorylation RLIMS-P 33536006


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S2 R2 Biomuta DOID:263 / kidney cancer [ cosmic ]
S28 F28 Biomuta [ cosmic ]
T254 N254 Biomuta DOID:3571 / liver cancer [ cosmic ]
T275 I275 Biomuta DOID:1319 / brain cancer [ cosmic ]
T279 M279 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ] DOID:9256 / colorectal cancer [ cosmic, icgc ] DOID:10534 / stomach cancer [ cosmic, icgc ]
T279 A279 Biomuta DOID:3571 / liver cancer [ cosmic, icgc ]
S282 L282 Biomuta DOID:363 / uterine cancer [ icgc ] DOID:4159 / skin cancer [ cosmic, icgc ] DOID:10534 / stomach cancer [ cosmic, icgc ] DOID:1324 / lung cancer [ cosmic, icgc ]
S282 * Biomuta DOID:3571 / liver cancer [ cosmic ]