iPTMnet Report for O43252 (PAPSS1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID O43252 / PAPS1_HUMAN
Protein Name Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 1
Gene Name Name: PAPSS1
Synonyms:ATPSK1,PAPSS;
Organism Homo sapiens (Human)

PRO ID PR:O43252
DAG View
PRO Name bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 1 (human)
Definition A bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 1 that is encoded in the genome of human.
Short Label hPAPSS1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


O43252 (PAPSS1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
M1 Acetylation UniProt 22223895
S6 Phosphorylation PhosphoSitePlus
K12 Ubiquitination PhosphoSitePlus
S14 Phosphorylation PhosphoSitePlus
T29 Phosphorylation PhosphoSitePlus
Y30 Phosphorylation PhosphoSitePlus
S36 Phosphorylation PhosphoSitePlus
R47 Methylation PhosphoSitePlus
K97 Ubiquitination PhosphoSitePlus
S102 Phosphorylation PhosphoSitePlus
C127 Methylation IEDB 31844290
K183 Ubiquitination PhosphoSitePlus
K194 Ubiquitination PhosphoSitePlus
C207 S-Nitrosylation dbSNO 26338901
C212 S-Nitrosylation dbSNO 26338901
K235 Ubiquitination PhosphoSitePlus
K243 Ubiquitination PhosphoSitePlus
K258 Ubiquitination PhosphoSitePlus
R354 Methylation PhosphoSitePlus
K361 Ubiquitination PhosphoSitePlus
K404 Ubiquitination PhosphoSitePlus
C507 Methylation IEDB 31844290
Y518 Phosphorylation HPRD   PhosphoSitePlus 20068231
T532 Phosphorylation PhosphoSitePlus
Y537 Phosphorylation PhosphoSitePlus
K600 Acetylation PhosphoSitePlus
K609 Acetylation PhosphoSitePlus
K619 Ubiquitination PhosphoSitePlus
K623 Ubiquitination PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K12 T12 Biomuta DOID:363 / uterine cancer [ icgc ]
K97 T97 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
K97 N97 Biomuta DOID:4362 / cervical cancer [ cosmic, icgc ]
C127 S127 Biomuta DOID:10283 / prostate cancer [ cosmic, icgc ]
C127 F127 Biomuta DOID:8618 / oral cavity cancer [ cosmic ]
K258 Q258 Biomuta DOID:1612 / breast cancer [ cosmic ]
Y518 C518 Biomuta DOID:1319 / brain cancer [ cosmic ]
K600 T600 Biomuta DOID:1793 / pancreatic cancer [ icgc ]