iPTMnet Report for O43187 (IRAK2)


Protein Information

Cytoscape View


UniProt AC / UniProt ID O43187 / IRAK2_HUMAN
Protein Name Interleukin-1 receptor-associated kinase-like 2
Gene Name Name: IRAK2
Organism Homo sapiens (Human)

PRO ID PR:O43187
DAG View
PRO Name interleukin-1 receptor-associated kinase-like 2 (human)
Definition An interleukin-1 receptor-associated kinase-like 2 that is encoded in the genome of human.
Short Label hIRAK2
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


O43187 (IRAK2) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
Phosphorylation PRO
Y4 Phosphorylation PhosphoSitePlus
Y6 Phosphorylation PhosphoSitePlus
S143 Phosphorylation PhosphoSitePlus
S144 Phosphorylation PhosphoSitePlus   UniProt 23186163
K176 Ubiquitination PhosphoSitePlus
K184 Ubiquitination PhosphoSitePlus
K215 Ubiquitination PhosphoSitePlus
K350 Ubiquitination PhosphoSitePlus
K363 Ubiquitination PhosphoSitePlus
S430 Phosphorylation PhosphoSitePlus
S434 Phosphorylation PhosphoSitePlus
S438 Phosphorylation PhosphoSitePlus
K443 Ubiquitination PhosphoSitePlus
K452 Ubiquitination PhosphoSitePlus
K457 Ubiquitination PhosphoSitePlus
K461 Acetylation PhosphoSitePlus


Proteoforms

PRO ID (Short Label) Sites PTM Enzyme Source PMID
PR:000048045 (hIRAK2/PhosRes+) p PRO


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S144 F144 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
K176 N176 Biomuta DOID:363 / uterine cancer [ icgc ]
K184 N184 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
K350 T350 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S438 L438 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K461 E461 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]